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Q2FUQ1

- RNPA_STAA8

UniProt

Q2FUQ1 - RNPA_STAA8

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Protein

Ribonuclease P protein component

Gene

rnpA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC
  2. tRNA binding Source: InterPro

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein componentUniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P proteinUniRule annotation
Short name:
RNaseP proteinUniRule annotation
Alternative name(s):
Protein C5UniRule annotation
Gene namesi
Name:rnpAUniRule annotation
Ordered Locus Names:SAOUHSC_03054
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Ribonuclease P protein componentPRO_1000021471Add
BLAST

Interactioni

Subunit structurei

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit (By similarity). Homodimer (Probable). Component of a possible RNA degradosome complex composed of cshA, eno, pfkA, pnp, rnjA, rnjB, rnpA and rny. Interacts specifically with RNA helicase CshA.1 PublicationCuratedUniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_03054.

Structurei

3D structure databases

ProteinModelPortaliQ2FUQ1.
SMRiQ2FUQ1. Positions 1-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RnpA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0594.
HOGENOMiHOG000266301.
KOiK03536.
OMAiVGHTAVM.
OrthoDBiEOG6C01C6.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00227. RNase_P.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view]
PfamiPF00825. Ribonuclease_P. 1 hit.
[Graphical view]
ProDomiPD003629. Ribonuclease_P. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00188. rnpA. 1 hit.
PROSITEiPS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FUQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLEKAYRIK KNADFQRIYK KGHSVANRQF VVYTCNNKEI DHFRLGISVS
60 70 80 90 100
KKLGNAVLRN KIKRAIRENF KVHKSHILAK DIIVIARQPA KDMTTLQIQN
110
SLEHVLKIAK VFNKKIK
Length:117
Mass (Da):13,652
Last modified:March 21, 2006 - v1
Checksum:iAD5172C3654E01F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD32036.1.
RefSeqiYP_501499.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD32036; ABD32036; SAOUHSC_03054.
GeneIDi3921317.
KEGGisao:SAOUHSC_03054.
PATRICi19583307. VBIStaAur99865_2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD32036.1 .
RefSeqi YP_501499.1. NC_007795.1.

3D structure databases

ProteinModelPortali Q2FUQ1.
SMRi Q2FUQ1. Positions 1-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_03054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD32036 ; ABD32036 ; SAOUHSC_03054 .
GeneIDi 3921317.
KEGGi sao:SAOUHSC_03054.
PATRICi 19583307. VBIStaAur99865_2759.

Phylogenomic databases

eggNOGi COG0594.
HOGENOMi HOG000266301.
KOi K03536.
OMAi VGHTAVM.
OrthoDBi EOG6C01C6.

Enzyme and pathway databases

BioCyci SAUR93061:GIWJ-2967-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
HAMAPi MF_00227. RNase_P.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view ]
Pfami PF00825. Ribonuclease_P. 1 hit.
[Graphical view ]
ProDomi PD003629. Ribonuclease_P. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54211. SSF54211. 1 hit.
TIGRFAMsi TIGR00188. rnpA. 1 hit.
PROSITEi PS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.
  2. "Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex."
    Roux C.M., DeMuth J.P., Dunman P.M.
    J. Bacteriol. 193:5520-5526(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CSHA, SUBUNIT.
    Strain: UAMS-1.

Entry informationi

Entry nameiRNPA_STAA8
AccessioniPrimary (citable) accession number: Q2FUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3