Q2FUD5 (Q2FUD5_METHJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	Mhun_1045

Organism

Methanospirillum hungatei (strain JF-1 / DSM 864)

Taxonomic identifier

323259 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length	839 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01897
Ligand	ATP-binding HAMAP MF_01897 DNA-binding HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase HAMAP MF_01897
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2FUD5 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 79040DCC250B53AA	FASTA	839	94,274
	10 20 30 40 50 60 MTSEESQQPL FVPKVNPVNI EEEMKSSYID YAMSVIIGRA IPDVRDGLKP VHRRSLFAMW 70 80 90 100 110 120 EMGNTHDKPY KKSARVVGDV MGKYHPHGDA SIYDTIVKMA QPFSYRMMLV DGQGNFGSVD 130 140 150 160 170 180 GDAPAAMRYT EVRLKREAEE LLTDLEKETV EFVPNFDESL QEPSVLPAKL PNLLINGSDG 190 200 210 220 230 240 IAVGIATKMP PHNLGEVCDA VCHYLEHPDT TVYELMQIMP GPDFPTGGII MGTDGIQNAY 250 260 270 280 290 300 LSGQGKLTVR GVAEIDESGK RNQIIITEIP YQVNKAKLIE HIAELVKEKR IEGISDLRDE 310 320 330 340 350 360 SDKDGMRIVI DLRKDARPQL ILNHLYKHTA LESTFGIINY AIVDRQPKIL GLIPLIEQFV 370 380 390 400 410 420 RHRITVITRR SEFDKRKAEE RVHILRGLLH AIDNIDAVIT TIRAAQTADE AKEALIAKFS 430 440 450 460 470 480 LDEAQAGAIL QMQLRRLAAL EKQKLIDERE QLEAEIRKLI ELLSSEDNIR AEISRELQEL 490 500 510 520 530 540 REKYADKRRT QITGDLQEIV REDLIPNKQV LVCLTHQNYV KHMDVDAYRV QGRGGRGVMG 550 560 570 580 590 600 ISIKDGDYVE QVFVANTHDH LLCFTSTGRA YWLRVFDIPE GSRQSKGKAI VNLLDLRSEE 610 620 630 640 650 660 RVTAVIPVQE FSSDRFFLFL TERGMIIKIP QDEFSRPRST GVNAISLREG DNLVHVMVSD 670 680 690 700 710 720 GSQEIIITTK YGQSLRFHEE QIPLRHRNAL GVIGMRMKDD DIVTSMTVIE EGKHLLTITS 730 740 750 760 770 780 SGYGKRTNFD EYRGHGRGTM GVRNIKLKRN DGIVTAFSAG PEEEIILMSA EGIVIRTSVE 790 800 810 820 830 KITIQGRSTQ GVRIMRLAAG DRVVGVTSLS PEEQKDISDD IPQAEIIDEG PDENGSSDE

References

[1]

"Complete sequence of Methanospirillum hungatei JF-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-1 / DSM 864.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000254 Genomic DNA. Translation: ABD40795.1.
RefSeq	YP_502514.1. NC_007796.1.
3D structure databases
ProteinModelPortal	Q2FUD5.
SMR	Q2FUD5. Positions 37-493.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FUD5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3924758.
GenomeReviews	Gene locus Mhun_1045 in contig CP000254_GR.
KEGG	mhu:Mhun_1045.
NMPDR	fig|323259.5.peg.1099.
Phylogenomic databases
eggNOG	arNOG05278.
HOGENOM	HBG635183.
OMA	TGRGRIY.
PhylomeDB	Q2FUD5.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 2 hits.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2FUD5_METHJ

Accession

Primary (citable) accession number: Q2FUD5

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)