Q2FU45 (PGP_METHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycolate phosphatase
Short name=PGP
Short name=PGPase
EC=3.1.3.18

Gene names

Ordered Locus Names:

Mhun_2939

Organism

Methanospirillum hungatei (strain JF-1 / DSM 864)

Taxonomic identifier

323259 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of 2-phosphoglycolate By similarity. HAMAP MF_01419
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_01419
Cofactor	Magnesium By similarity. HAMAP MF_01419
Sequence similarities	Belongs to the archaeal SPP-like hydrolase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Phosphoglycolate phosphatase HAMAP MF_01419		PRO_1000024290
Sites
	Active site	8	1	Nucleophile By similarity
	Metal binding	8	1	Magnesium By similarity
	Metal binding	10	1	Magnesium By similarity
	Metal binding	178	1	Magnesium By similarity
	Metal binding	182	1	Magnesium By similarity
	Binding site	155	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2FU45 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: F29A4BEF8D2BC7DB	FASTA	232	25,482
	10 20 30 40 50 60 MLRGVITDID GTLTDEKRRL STAAIETIRK LQEGGIEVVL SSGNTSCLLK GLCKLIGTGG 70 80 90 100 110 120 TFIGENGGVY RIGFQGSMQV MANRDIAVKA LNLLEEYYGK KGIRLELYSH QERYSDIAFA 130 140 150 160 170 180 REVPVEEVRS LLSGWPVDIM DTNFAIHIHE AGIDKGRTFH IVAEQLGIKP DEFLGIGDSE 190 200 210 220 230 NDIGMIKAAG TGCCVANAQE DVRNISDYCS SVPYGEGFVE IMRMYFPHIL AR

References

[1]

"Complete sequence of Methanospirillum hungatei JF-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-1 / DSM 864.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000254 Genomic DNA. Translation: ABD42631.1.
RefSeq	YP_504350.1. NC_007796.1.
3D structure databases
ProteinModelPortal	Q2FU45.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FU45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3925106.
GenomeReviews	Gene locus Mhun_2939 in contig CP000254_GR.
KEGG	mhu:Mhun_2939.
NMPDR	fig|323259.5.peg.3076.
Phylogenomic databases
eggNOG	arNOG09493.
HOGENOM	HBG551920.
OMA	IDTGFAI.
PhylomeDB	Q2FU45.
ProtClustDB	CLSK949941.
Enzyme and pathway databases
BioCyc	MHUN323259:MHUN_2939-MONOMER.
Family and domain databases
HAMAP	MF_01419. GPH_hydrolase_arch. [Tree]
InterPro	IPR023214. HAD-like_dom. IPR013200. HAD-SF_hydro-like_3. IPR006382. SPPlik_hydro_arc. IPR006378. Suc_phosP. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K07024.
Pfam	PF08282. Hydrolase_3. 2 hits. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01487. SPP-like. 1 hit. TIGR01482. SPP-subfamily. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PGP_METHJ

Accession

Primary (citable) accession number: Q2FU45

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program