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Protein

AMP phosphorylase

Gene

Mhun_2262

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Active sitei257Proton donorUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMHUN323259:G1G5Z-2388-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Mhun_2262
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147301 – 516AMP phosphorylaseAdd BLAST516

Interactioni

Protein-protein interaction databases

STRINGi323259.Mhun_2262

Structurei

3D structure databases

ProteinModelPortaliQ2FTS5
SMRiQ2FTS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 2 hits
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FTS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTVRLVDI AARGILLHHN DAKSLGVLAG DRIVISSPVT GKATVDYVET
60 70 80 90 100
TGTLIDQGRI GVYHHTNEQL TLTENEVVEV RVADRPVSLD YIKKKMEGEK
110 120 130 140 150
LTREDIRAIV ADIVQDTLSP SEITAFVVSS YINQLDMDEI ESLTRAMVET
160 170 180 190 200
GDQLSFHAGP IVDKHSIGGV PGNKISLIVV PIIAASGLLI PKTSSRAITG
210 220 230 240 250
AGGTADLMEV LAPVEFSASE VQEMTIKTGG VIVWGGATNI APADDKIIIQ
260 270 280 290 300
EYPFKIDQIG QMIASVMAKK FAVGADVVAI DIPVGKYCKV HTIEEGKKLA
310 320 330 340 350
RQFIDLGERL NMRVECALTY GDAPVGRAIG PKLEIKEALS VLEGSDSPRS
360 370 380 390 400
LIQKSCVIAG IALELAGKAN RGEGANLALE ILRSGKALKK FLDIIAVQGG
410 420 430 440 450
TPDVSSEKIT VGEHFYTVRA DSTGYVIDLN NHSLITIART AGAPADHGAG
460 470 480 490 500
LYLHAKHGTS LSKGDPIFTI YADRKWRLEK AIEEARRLRP VMVEGMLIDR
510
VPNVREWVPG RSRNLE
Length:516
Mass (Da):55,655
Last modified:March 21, 2006 - v1
Checksum:iD083C5B88381B8AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD41967.1
RefSeqiWP_011449225.1, NC_007796.1

Genome annotation databases

EnsemblBacteriaiABD41967; ABD41967; Mhun_2262
GeneIDi3924224
KEGGimhu:Mhun_2262

Similar proteinsi

Entry informationi

Entry nameiAMPPA_METHJ
AccessioniPrimary (citable) accession number: Q2FTS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health