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Q2FTS5

- AMPPA_METHJ

UniProt

Q2FTS5 - AMPPA_METHJ

Protein

AMP phosphorylase

Gene

Mhun_2262

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei169 – 1691AMP; via amide nitrogenUniRule annotation
    Binding sitei204 – 2041AMP; via amide nitrogenUniRule annotation
    Active sitei257 – 2571Proton donorUniRule annotation
    Binding sitei265 – 2651AMPUniRule annotation
    Binding sitei289 – 2891AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 2006AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMHUN323259:GH0L-2287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpaseUniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylaseUniRule annotation
    Short name:
    NMP phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Mhun_2262
    OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
    Taxonomic identifieri323259 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
    ProteomesiUP000001941: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516AMP phosphorylasePRO_0000314730Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323259.Mhun_2262.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2FTS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiESVPGFH.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2FTS5-1 [UniParc]FASTAAdd to Basket

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    MRLTVRLVDI AARGILLHHN DAKSLGVLAG DRIVISSPVT GKATVDYVET    50
    TGTLIDQGRI GVYHHTNEQL TLTENEVVEV RVADRPVSLD YIKKKMEGEK 100
    LTREDIRAIV ADIVQDTLSP SEITAFVVSS YINQLDMDEI ESLTRAMVET 150
    GDQLSFHAGP IVDKHSIGGV PGNKISLIVV PIIAASGLLI PKTSSRAITG 200
    AGGTADLMEV LAPVEFSASE VQEMTIKTGG VIVWGGATNI APADDKIIIQ 250
    EYPFKIDQIG QMIASVMAKK FAVGADVVAI DIPVGKYCKV HTIEEGKKLA 300
    RQFIDLGERL NMRVECALTY GDAPVGRAIG PKLEIKEALS VLEGSDSPRS 350
    LIQKSCVIAG IALELAGKAN RGEGANLALE ILRSGKALKK FLDIIAVQGG 400
    TPDVSSEKIT VGEHFYTVRA DSTGYVIDLN NHSLITIART AGAPADHGAG 450
    LYLHAKHGTS LSKGDPIFTI YADRKWRLEK AIEEARRLRP VMVEGMLIDR 500
    VPNVREWVPG RSRNLE 516
    Length:516
    Mass (Da):55,655
    Last modified:March 21, 2006 - v1
    Checksum:iD083C5B88381B8AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000254 Genomic DNA. Translation: ABD41967.1.
    RefSeqiWP_011449225.1. NC_007796.1.
    YP_503686.1. NC_007796.1.

    Genome annotation databases

    EnsemblBacteriaiABD41967; ABD41967; Mhun_2262.
    GeneIDi3924224.
    KEGGimhu:Mhun_2262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000254 Genomic DNA. Translation: ABD41967.1 .
    RefSeqi WP_011449225.1. NC_007796.1.
    YP_503686.1. NC_007796.1.

    3D structure databases

    ProteinModelPortali Q2FTS5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323259.Mhun_2262.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD41967 ; ABD41967 ; Mhun_2262 .
    GeneIDi 3924224.
    KEGGi mhu:Mhun_2262.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi ESVPGFH.

    Enzyme and pathway databases

    BioCyci MHUN323259:GH0L-2287-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27890 / DSM 864 / NBRC 100397 / JF-1.

    Entry informationi

    Entry nameiAMPPA_METHJ
    AccessioniPrimary (citable) accession number: Q2FTS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3