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Protein

AMP phosphorylase

Gene

Mhun_2262

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Active sitei257Proton donorUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Mhun_2262
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147301 – 516AMP phosphorylaseAdd BLAST516

Interactioni

Protein-protein interaction databases

STRINGi323259.Mhun_2262.

Structurei

3D structure databases

ProteinModelPortaliQ2FTS5.
SMRiQ2FTS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013. Archaea.
COG0213. LUCA.
HOGENOMiHOG000252767.
KOiK18931.
OMAiVHSIGGV.
OrthoDBiPOG093Z01M3.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase. 1 hit.
InterProiView protein in InterPro
IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiView protein in Pfam
PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiView protein in SMART
SM00941. PYNP_C. 1 hit.
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiView protein in PROSITE
PS00647. THYMID_PHOSPHORYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FTS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTVRLVDI AARGILLHHN DAKSLGVLAG DRIVISSPVT GKATVDYVET
60 70 80 90 100
TGTLIDQGRI GVYHHTNEQL TLTENEVVEV RVADRPVSLD YIKKKMEGEK
110 120 130 140 150
LTREDIRAIV ADIVQDTLSP SEITAFVVSS YINQLDMDEI ESLTRAMVET
160 170 180 190 200
GDQLSFHAGP IVDKHSIGGV PGNKISLIVV PIIAASGLLI PKTSSRAITG
210 220 230 240 250
AGGTADLMEV LAPVEFSASE VQEMTIKTGG VIVWGGATNI APADDKIIIQ
260 270 280 290 300
EYPFKIDQIG QMIASVMAKK FAVGADVVAI DIPVGKYCKV HTIEEGKKLA
310 320 330 340 350
RQFIDLGERL NMRVECALTY GDAPVGRAIG PKLEIKEALS VLEGSDSPRS
360 370 380 390 400
LIQKSCVIAG IALELAGKAN RGEGANLALE ILRSGKALKK FLDIIAVQGG
410 420 430 440 450
TPDVSSEKIT VGEHFYTVRA DSTGYVIDLN NHSLITIART AGAPADHGAG
460 470 480 490 500
LYLHAKHGTS LSKGDPIFTI YADRKWRLEK AIEEARRLRP VMVEGMLIDR
510
VPNVREWVPG RSRNLE
Length:516
Mass (Da):55,655
Last modified:March 21, 2006 - v1
Checksum:iD083C5B88381B8AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD41967.1.
RefSeqiWP_011449225.1. NC_007796.1.

Genome annotation databases

EnsemblBacteriaiABD41967; ABD41967; Mhun_2262.
GeneIDi3924224.
KEGGimhu:Mhun_2262.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAMPPA_METHJ
AccessioniPrimary (citable) accession number: Q2FTS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: June 7, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families