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Q2FTS5

- AMPPA_METHJ

UniProt

Q2FTS5 - AMPPA_METHJ

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Protein

AMP phosphorylase

Gene

Mhun_2262

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei169 – 1691AMP; via amide nitrogenUniRule annotation
Binding sitei204 – 2041AMP; via amide nitrogenUniRule annotation
Active sitei257 – 2571Proton donorUniRule annotation
Binding sitei265 – 2651AMPUniRule annotation
Binding sitei289 – 2891AMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 2006AMPUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: InterPro

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMHUN323259:GH0L-2287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Mhun_2262
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
ProteomesiUP000001941: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516AMP phosphorylasePRO_0000314730Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323259.Mhun_2262.

Structurei

3D structure databases

ProteinModelPortaliQ2FTS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiESVPGFH.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FTS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLTVRLVDI AARGILLHHN DAKSLGVLAG DRIVISSPVT GKATVDYVET
60 70 80 90 100
TGTLIDQGRI GVYHHTNEQL TLTENEVVEV RVADRPVSLD YIKKKMEGEK
110 120 130 140 150
LTREDIRAIV ADIVQDTLSP SEITAFVVSS YINQLDMDEI ESLTRAMVET
160 170 180 190 200
GDQLSFHAGP IVDKHSIGGV PGNKISLIVV PIIAASGLLI PKTSSRAITG
210 220 230 240 250
AGGTADLMEV LAPVEFSASE VQEMTIKTGG VIVWGGATNI APADDKIIIQ
260 270 280 290 300
EYPFKIDQIG QMIASVMAKK FAVGADVVAI DIPVGKYCKV HTIEEGKKLA
310 320 330 340 350
RQFIDLGERL NMRVECALTY GDAPVGRAIG PKLEIKEALS VLEGSDSPRS
360 370 380 390 400
LIQKSCVIAG IALELAGKAN RGEGANLALE ILRSGKALKK FLDIIAVQGG
410 420 430 440 450
TPDVSSEKIT VGEHFYTVRA DSTGYVIDLN NHSLITIART AGAPADHGAG
460 470 480 490 500
LYLHAKHGTS LSKGDPIFTI YADRKWRLEK AIEEARRLRP VMVEGMLIDR
510
VPNVREWVPG RSRNLE
Length:516
Mass (Da):55,655
Last modified:March 21, 2006 - v1
Checksum:iD083C5B88381B8AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD41967.1.
RefSeqiWP_011449225.1. NC_007796.1.
YP_503686.1. NC_007796.1.

Genome annotation databases

EnsemblBacteriaiABD41967; ABD41967; Mhun_2262.
GeneIDi3924224.
KEGGimhu:Mhun_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD41967.1 .
RefSeqi WP_011449225.1. NC_007796.1.
YP_503686.1. NC_007796.1.

3D structure databases

ProteinModelPortali Q2FTS5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323259.Mhun_2262.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD41967 ; ABD41967 ; Mhun_2262 .
GeneIDi 3924224.
KEGGi mhu:Mhun_2262.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi ESVPGFH.

Enzyme and pathway databases

BioCyci MHUN323259:GH0L-2287-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27890 / DSM 864 / NBRC 100397 / JF-1.

Entry informationi

Entry nameiAMPPA_METHJ
AccessioniPrimary (citable) accession number: Q2FTS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3