Q2FTL1 (Q2FTL1_METHJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Porphobilinogen synthase EMBL ABD42260.1
EC=4.2.1.24 EMBL ABD42260.1

Gene names

Ordered Locus Names:

Mhun_2561

Organism

Methanospirillum hungatei (strain JF-1 / DSM 864)

Taxonomic identifier

323259 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL ABD42260.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	191	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	244	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	112	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	114	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	122	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	229	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	201	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	213	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	269	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	308	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q2FTL1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 03B1AA011DE76AE0	FASTA	321	35,167
	10 20 30 40 50 60 MRRLRRQKII PLLAETHIGK DDLIAPLFFD ENIAEPVPIL AMPGQNRWPV SMAAEVVTRM 70 80 90 100 110 120 RTAGIRAVLL FGIPSVKDAE ASGAYAPEGV IQQVIRAMKK TCPDMVIITD LCACEYTDHG 130 140 150 160 170 180 HCGYVGECCD GPNLLNDASL EMMQRIAVSQ AEAGADIVAP SCMLDGMVAA IREALDDYGH 190 200 210 220 230 240 QEVLIMSYSS KFASALYGPF REAAGSGFSF GDRTGYQAPV SNRREAYRES EQDAAEGADI 250 260 270 280 290 300 LMVKPAGWFG DVITDIKQLG LPVAAYQVSG EYSMIRAATE MGWLDERRVV MESLVSLKRA 310 320 GADLIITYFA EDVCRWLSEH E

References

[1]

"Complete sequence of Methanospirillum hungatei JF-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-1 / DSM 864.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000254 Genomic DNA. Translation: ABD42260.1.
RefSeq	YP_503979.1. NC_007796.1.
3D structure databases
ProteinModelPortal	Q2FTL1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FTL1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3922818.
GenomeReviews	Gene locus Mhun_2561 in contig CP000254_GR.
KEGG	mhu:Mhun_2561.
NMPDR	fig|323259.5.peg.2688.
Phylogenomic databases
eggNOG	arNOG05029.
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	Q2FTL1.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2FTL1_METHJ

Accession

Primary (citable) accession number: Q2FTL1

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)