Q2FTC2 (NADM_METHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinamide-nucleotide adenylyltransferase
EC=2.7.7.1

Alternative name(s):
NAD(+) diphosphorylase
NAD(+) pyrophosphorylase
NMN adenylyltransferase

Gene names

Ordered Locus Names:

Mhun_2915

Organism

Methanospirillum hungatei (strain JF-1 / DSM 864)

Taxonomic identifier

323259 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + nicotinamide ribonucleotide = diphosphate + NAD+. HAMAP MF_00243
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. HAMAP MF_00243
Subcellular location	Cytoplasm By similarity HAMAP MF_00243.
Sequence similarities	Belongs to the archaeal NMN adenylyltransferase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinamide-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Nicotinamide-nucleotide adenylyltransferase HAMAP MF_00243		PRO_1000005736

Sequences

	Sequence		Length	Mass (Da)
	Q2FTC2 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 27A3B19830D21921	FASTA	174	19,600
	10 20 30 40 50 60 MIRALYIGRF QPYHNGHHYV INQIAQEADE LIIGIGSAQM SHEPADPFTA GERVLMITGA 70 80 90 100 110 120 LQDLHKPLYV IPLEDINRNV LWVSHVRAMT PPFHRIYSGN PLVIRLFHEA GIEVLSPAMY 130 140 150 160 170 ERATLSGTKI RDLIACDKPW EDFVPPAVVR VIQEIDGISR IRALNQDDGD CPGR

References

[1]

"Complete sequence of Methanospirillum hungatei JF-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-1 / DSM 864.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000254 Genomic DNA. Translation: ABD42607.1.
RefSeq	YP_504326.1. NC_007796.1.
3D structure databases
ProteinModelPortal	Q2FTC2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FTC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3924686.
GenomeReviews	Gene locus Mhun_2915 in contig CP000254_GR.
KEGG	mhu:Mhun_2915.
NMPDR	fig|323259.5.peg.3052.
Phylogenomic databases
eggNOG	arNOG10577.
HOGENOM	HBG392019.
OMA	FHKGHLE.
Enzyme and pathway databases
BioCyc	MHUN323259:MHUN_2915-MONOMER.
Family and domain databases
HAMAP	MF_00243. NMN_adenylyltr. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR006418. NMN_Atrans_arc. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00952.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01527. Arch_NMN_Atrans. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADM_METHJ

Accession

Primary (citable) accession number: Q2FTC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program