Reviewed, UniProtKB/Swiss-Prot Q2FTC2 (NADM_METHJ)

Names and origin

Protein names

Recommended name:
    Nicotinamide-nucleotide adenylyltransferase
    EC=2.7.7.1
Alternative name(s):
    NAD(+) pyrophosphorylase
    NAD(+) diphosphorylase
    NMN adenylyltransferase

Gene names

Ordered Locus Names:

Mhun_2915

Organism

Methanospirillum hungatei (strain JF-1 / DSM 864) [Complete proteome] [HAMAP]

Taxonomic identifier

323259 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + nicotinamide ribonucleotide = diphosphate + NAD+. HAMAP MF_00243
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide ribonucleotide: step 1/1. HAMAP MF_00243
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the archaeal NMN adenylyltransferase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinamide-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Nicotinamide-nucleotide adenylyltransferase HAMAP MF_00243		PRO_1000005736

Sequences

	Sequence		Length	Mass (Da)
	Q2FTC2-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 27A3B19830D21921	FASTA	174	19,600
	10 20 30 40 50 60 MIRALYIGRF QPYHNGHHYV INQIAQEADE LIIGIGSAQM SHEPADPFTA GERVLMITGA 70 80 90 100 110 120 LQDLHKPLYV IPLEDINRNV LWVSHVRAMT PPFHRIYSGN PLVIRLFHEA GIEVLSPAMY 130 140 150 160 170 ERATLSGTKI RDLIACDKPW EDFVPPAVVR VIQEIDGISR IRALNQDDGD CPGR

References

[1]

"Complete sequence of Methanospirillum hungatei JF-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000254 Genomic DNA. Translation: ABD42607.1.
RefSeq	YP_504326.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3924686.
GenomeReviews	Gene locus Mhun_2915 in contig CP000254_GR.
KEGG	mhu:Mhun_2915.
NMPDR	fig|323259.5.peg.3052.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FTC2.
OMA	Q2FTC2. IGRFQPY.
Enzyme and pathway databases
BioCyc	MHUN323259:MHUN_2915-MON.
Family and domain databases
HAMAP	MF_00243. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR004820. Cytidylyltransf. IPR006418. NMN_Atrans_arc. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01527. arch_NMN_Atrans. 1 hit. TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADM_METHJ

Accession

Primary (citable) accession number: Q2FTC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)