ID   Q2FT11_METHJ            Unreviewed;       318 AA.
AC   Q2FT11;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000256|ARBA:ARBA00020597, ECO:0000256|HAMAP-Rule:MF_00486};
DE            EC=3.5.4.27 {ECO:0000256|ARBA:ARBA00012765, ECO:0000256|HAMAP-Rule:MF_00486};
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000256|ARBA:ARBA00030468, ECO:0000256|HAMAP-Rule:MF_00486};
GN   Name=mch {ECO:0000256|HAMAP-Rule:MF_00486};
GN   OrderedLocusNames=Mhun_2384 {ECO:0000313|EMBL:ABD42086.1};
OS   Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS   JF-1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259 {ECO:0000313|EMBL:ABD42086.1, ECO:0000313|Proteomes:UP000001941};
RN   [1] {ECO:0000313|Proteomes:UP000001941}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1
RC   {ECO:0000313|Proteomes:UP000001941};
RX   PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA   Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA   Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA   Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT   "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL   Stand. Genomic Sci. 11:2-2(2016).
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC       to methenyl-H(4)MPT(+). {ECO:0000256|HAMAP-Rule:MF_00486}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27;
CC         Evidence={ECO:0000256|ARBA:ARBA00001727, ECO:0000256|HAMAP-
CC         Rule:MF_00486};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC       {ECO:0000256|HAMAP-Rule:MF_00486}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_00486}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000256|ARBA:ARBA00006902,
CC       ECO:0000256|HAMAP-Rule:MF_00486}.
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DR   EMBL; CP000254; ABD42086.1; -; Genomic_DNA.
DR   RefSeq; WP_011449344.1; NC_007796.1.
DR   AlphaFoldDB; Q2FT11; -.
DR   STRING; 323259.Mhun_2384; -.
DR   EnsemblBacteria; ABD42086; ABD42086; Mhun_2384.
DR   GeneID; 3923282; -.
DR   KEGG; mhu:Mhun_2384; -.
DR   eggNOG; arCOG02675; Archaea.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   InParanoid; Q2FT11; -.
DR   OrthoDB; 105468at2157; -.
DR   UniPathway; UPA00640; UER00694.
DR   Proteomes; UP000001941; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   NCBIfam; TIGR03120; one_C_mch; 1.
DR   Pfam; PF02289; MCH; 1.
DR   SUPFAM; SSF56199; Methenyltetrahydromethanopterin cyclohydrolase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00486};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00486};
KW   Methanogenesis {ECO:0000256|HAMAP-Rule:MF_00486};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563, ECO:0000256|HAMAP-
KW   Rule:MF_00486}; Reference proteome {ECO:0000313|Proteomes:UP000001941}.
SQ   SEQUENCE   318 AA;  34850 MW;  F7C58BDD9F624C6F CRC64;
     MISVNTNALP VVLDMIRNAE ILGIKVHSLE NGATLIDCGV MENGCHEAGL QFLKVCAGGL
     IEPTIVHQPI AGQIFPFVHL TVKHPIIACL GSQKAGWVIK RNRFFAMGSG PARALALKPK
     GTYQAIQYYD TSDVAIITLE AGMLPDAEVC EYIADKCGVK PSCLYALVAS TRSIVGSIQI
     SGRIVTMAMH KLEDMGYDLS NIVNAAGRSP VAPVKRTFEQ AMGVTNDCNI YYGSVIISTR
     FYSDDFSRIT SDNSEMYGRP FYELFRNANY DIVNIGSYLG FSPAELTVND CTTGKIYHFG
     RLNEEVLLES FQATYERV
//