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Protein

Methenyltetrahydromethanopterin cyclohydrolase

Gene

mch

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of 5-formyl-H4MPT to methenyl-H4MPT+.UniRule annotation

Catalytic activityi

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin.UniRule annotation

Pathway: methanogenesis from CO(2)

This protein is involved in step 3 of the subpathway that synthesizes 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Formylmethanofuran--tetrahydromethanopterin formyltransferase (ftr)
  3. Methenyltetrahydromethanopterin cyclohydrolase (mch), Methenyltetrahydromethanopterin cyclohydrolase (mch)
This subpathway is part of the pathway methanogenesis from CO(2), which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2), the pathway methanogenesis from CO(2) and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

MethanogenesisUniRule annotation, One-carbon metabolismUniRule annotation

Enzyme and pathway databases

BioCyciMHUN323259:GH0L-2416-MONOMER.
UniPathwayiUPA00640; UER00694.

Names & Taxonomyi

Protein namesi
Recommended name:
Methenyltetrahydromethanopterin cyclohydrolaseUniRule annotation (EC:3.5.4.27UniRule annotation)
Alternative name(s):
Methenyl-H4MPT cyclohydrolaseUniRule annotation
Gene namesi
Name:mchUniRule annotation
Ordered Locus Names:Mhun_2384Imported
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)Imported
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
ProteomesiUP000001941 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi323259.Mhun_2384.

Structurei

3D structure databases

ProteinModelPortaliQ2FT11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MCH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3252.
HOGENOMiHOG000224079.
KOiK01499.

Family and domain databases

HAMAPiMF_00486. McH.
InterProiIPR003209. METHMP_CycHdrlase.
[Graphical view]
PfamiPF02289. MCH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03120. one_C_mch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FT11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISVNTNALP VVLDMIRNAE ILGIKVHSLE NGATLIDCGV MENGCHEAGL
60 70 80 90 100
QFLKVCAGGL IEPTIVHQPI AGQIFPFVHL TVKHPIIACL GSQKAGWVIK
110 120 130 140 150
RNRFFAMGSG PARALALKPK GTYQAIQYYD TSDVAIITLE AGMLPDAEVC
160 170 180 190 200
EYIADKCGVK PSCLYALVAS TRSIVGSIQI SGRIVTMAMH KLEDMGYDLS
210 220 230 240 250
NIVNAAGRSP VAPVKRTFEQ AMGVTNDCNI YYGSVIISTR FYSDDFSRIT
260 270 280 290 300
SDNSEMYGRP FYELFRNANY DIVNIGSYLG FSPAELTVND CTTGKIYHFG
310
RLNEEVLLES FQATYERV
Length:318
Mass (Da):34,850
Last modified:March 21, 2006 - v1
Checksum:iF7C58BDD9F624C6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD42086.1.
RefSeqiWP_011449344.1. NC_007796.1.
YP_503805.1. NC_007796.1.

Genome annotation databases

EnsemblBacteriaiABD42086; ABD42086; Mhun_2384.
GeneIDi3923282.
KEGGimhu:Mhun_2384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD42086.1.
RefSeqiWP_011449344.1. NC_007796.1.
YP_503805.1. NC_007796.1.

3D structure databases

ProteinModelPortaliQ2FT11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323259.Mhun_2384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD42086; ABD42086; Mhun_2384.
GeneIDi3923282.
KEGGimhu:Mhun_2384.

Phylogenomic databases

eggNOGiCOG3252.
HOGENOMiHOG000224079.
KOiK01499.

Enzyme and pathway databases

UniPathwayiUPA00640; UER00694.
BioCyciMHUN323259:GH0L-2416-MONOMER.

Family and domain databases

HAMAPiMF_00486. McH.
InterProiIPR003209. METHMP_CycHdrlase.
[Graphical view]
PfamiPF02289. MCH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03120. one_C_mch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27890 / DSM 864 / NBRC 100397 / JF-1Imported.

Entry informationi

Entry nameiQ2FT11_METHJ
AccessioniPrimary (citable) accession number: Q2FT11
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: May 27, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.