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Protein

Methenyltetrahydromethanopterin cyclohydrolase

Gene

mch

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of 5-formyl-H4MPT to methenyl-H4MPT+.UniRule annotation

Catalytic activityi

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin.UniRule annotation

Pathwayi: methanogenesis from CO(2)

This protein is involved in step 3 of the subpathway that synthesizes 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Formylmethanofuran--tetrahydromethanopterin formyltransferase (ftr)
  3. Methenyltetrahydromethanopterin cyclohydrolase (mch), Methenyltetrahydromethanopterin cyclohydrolase (mch)
This subpathway is part of the pathway methanogenesis from CO(2), which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2), the pathway methanogenesis from CO(2) and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processMethanogenesisUniRule annotation, One-carbon metabolismUniRule annotation

Enzyme and pathway databases

BioCyciMHUN323259:G1G5Z-2523-MONOMER
UniPathwayiUPA00640; UER00694

Names & Taxonomyi

Protein namesi
Recommended name:
Methenyltetrahydromethanopterin cyclohydrolaseUniRule annotation (EC:3.5.4.27UniRule annotation)
Alternative name(s):
Methenyl-H4MPT cyclohydrolaseUniRule annotation
Gene namesi
Name:mchUniRule annotation
Ordered Locus Names:Mhun_2384Imported
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)Imported
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi323259.Mhun_2384

Structurei

3D structure databases

ProteinModelPortaliQ2FT11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MCH family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02675 Archaea
COG3252 LUCA
HOGENOMiHOG000224079
KOiK01499
OMAiNDCNIYY
OrthoDBiPOG093Z07WI

Family and domain databases

HAMAPiMF_00486 McH, 1 hit
InterProiView protein in InterPro
IPR003209 METHMP_CycHdrlase
PfamiView protein in Pfam
PF02289 MCH, 1 hit
TIGRFAMsiTIGR03120 one_C_mch, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FT11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISVNTNALP VVLDMIRNAE ILGIKVHSLE NGATLIDCGV MENGCHEAGL
60 70 80 90 100
QFLKVCAGGL IEPTIVHQPI AGQIFPFVHL TVKHPIIACL GSQKAGWVIK
110 120 130 140 150
RNRFFAMGSG PARALALKPK GTYQAIQYYD TSDVAIITLE AGMLPDAEVC
160 170 180 190 200
EYIADKCGVK PSCLYALVAS TRSIVGSIQI SGRIVTMAMH KLEDMGYDLS
210 220 230 240 250
NIVNAAGRSP VAPVKRTFEQ AMGVTNDCNI YYGSVIISTR FYSDDFSRIT
260 270 280 290 300
SDNSEMYGRP FYELFRNANY DIVNIGSYLG FSPAELTVND CTTGKIYHFG
310
RLNEEVLLES FQATYERV
Length:318
Mass (Da):34,850
Last modified:March 21, 2006 - v1
Checksum:iF7C58BDD9F624C6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD42086.1
RefSeqiWP_011449344.1, NC_007796.1

Genome annotation databases

EnsemblBacteriaiABD42086; ABD42086; Mhun_2384
GeneIDi3923282
KEGGimhu:Mhun_2384

Similar proteinsi

Entry informationi

Entry nameiQ2FT11_METHJ
AccessioniPrimary (citable) accession number: Q2FT11
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported