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Protein

Cysteate synthase

Gene

Mhun_2977

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.UniRule annotation

Catalytic activityi

O-phospho-L-serine + sulfite = L-cysteate + phosphate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: coenzyme M biosynthesis

This protein is involved in the pathway coenzyme M biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme M biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131Pyridoxal phosphateUniRule annotation1
Binding sitei379Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Coenzyme M biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00355.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteate synthaseUniRule annotation (EC:2.5.1.76UniRule annotation)
Short name:
CSUniRule annotation
Short name:
Cya synthaseUniRule annotation
Gene namesi
Ordered Locus Names:Mhun_2977
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003926551 – 422Cysteate synthaseAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi323259.Mhun_2977.

Structurei

3D structure databases

ProteinModelPortaliQ2FSC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family. Cysteate synthase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01434. Archaea.
COG0498. LUCA.
HOGENOMiHOG000226437.
KOiK15527.
OMAiTCSFKEL.

Family and domain databases

HAMAPiMF_02109. Cya_synthase. 1 hit.
InterProiIPR022401. Cysteate_synthase.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR03844. cysteate_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FSC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGYTLTCPV CNKEFSDSYT LTCPGGCQGL IRAKYAARQI TLHDAPGVFK
60 70 80 90 100
YMDWLPVTGV LRTRAEPVCF KSEGLARALG LSDLWIVFSG YWPEVGAFAV
110 120 130 140 150
SGSFKEFEAF PTMQRLSERT KGIIQVSSAG NTGRAFAEVS AETCQPVIIV
160 170 180 190 200
VPESARDRLF TTSPAHDTLL ITISGDYTDA INLGSRICTL PGIFPEGGAK
210 220 230 240 250
NVARRDGMGT VMLAGTLAMG TLPDWYLQAV GSGTGGIAAY EASLRLIADG
260 270 280 290 300
RFGTRMPRLL LFQNEPFIPM VRAWQEKRRE IKDEDMPDAE QAISQVYSDV
310 320 330 340 350
LTNRTPPYGI VGGVFDTLIA TNGLMAGVSS ADAQEAGKLF SSSEGIDPDP
360 370 380 390 400
AAAVCVAGLM RAVRSGVIKP DEKILLNITG GGYARGRKDL PRFVKAPDIM
410 420
VSKETPFEKI SAKVQEWMRY YA
Length:422
Mass (Da):45,660
Last modified:March 21, 2006 - v1
Checksum:iAFB64CF5F7C5B2C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD42664.1.
RefSeqiWP_011449917.1. NC_007796.1.

Genome annotation databases

EnsemblBacteriaiABD42664; ABD42664; Mhun_2977.
GeneIDi3922460.
KEGGimhu:Mhun_2977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD42664.1.
RefSeqiWP_011449917.1. NC_007796.1.

3D structure databases

ProteinModelPortaliQ2FSC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323259.Mhun_2977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD42664; ABD42664; Mhun_2977.
GeneIDi3922460.
KEGGimhu:Mhun_2977.

Phylogenomic databases

eggNOGiarCOG01434. Archaea.
COG0498. LUCA.
HOGENOMiHOG000226437.
KOiK15527.
OMAiTCSFKEL.

Enzyme and pathway databases

UniPathwayiUPA00355.

Family and domain databases

HAMAPiMF_02109. Cya_synthase. 1 hit.
InterProiIPR022401. Cysteate_synthase.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR03844. cysteate_syn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYAS_METHJ
AccessioniPrimary (citable) accession number: Q2FSC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.