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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871ZincUniRule annotation
Metal bindingi195 – 1951ZincUniRule annotation
Metal bindingi198 – 1981ZincUniRule annotation
Metal bindingi201 – 2011ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 1711ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMHUN323259:GH0L-2874-MONOMER.
UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine synthaseUniRule annotation
Archaeosine biosynthesis protein QueCUniRule annotation
PreQ(0) synthaseUniRule annotation
Gene namesi
Name:queCUniRule annotation
Ordered Locus Names:Mhun_2833
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2202207-cyano-7-deazaguanine synthasePRO_0000246982Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323259.Mhun_2833.

Structurei

3D structure databases

ProteinModelPortaliQ2FS65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiEKTWSCY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FS65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVCLLSGG MDSSTLACLA KHDGYDILAL HFSYGQRTEE KERECAKRIA
60 70 80 90 100
RHLNALEFLE VDLTYLKAVG ASSLTDYAMQ VKAHEDAGDG IPDTYVPFRN
110 120 130 140 150
ANLLSVATSF AEARGADAIY IGVQASDYSG YPDCRPEFID AFQKVITLGT
160 170 180 190 200
RPDAGIILKT PFVKLNKAEI LKIGMDLNVP YEDTWSCYAE NEVACGICGS
210 220
CHYRLEAFRQ IGIQDPIPYR
Length:220
Mass (Da):24,277
Last modified:March 21, 2006 - v1
Checksum:iB2BBB8279D12003D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD42525.1.
RefSeqiWP_011449779.1. NC_007796.1.

Genome annotation databases

EnsemblBacteriaiABD42525; ABD42525; Mhun_2833.
GeneIDi3923102.
KEGGimhu:Mhun_2833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD42525.1.
RefSeqiWP_011449779.1. NC_007796.1.

3D structure databases

ProteinModelPortaliQ2FS65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323259.Mhun_2833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD42525; ABD42525; Mhun_2833.
GeneIDi3923102.
KEGGimhu:Mhun_2833.

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiEKTWSCY.

Enzyme and pathway databases

UniPathwayiUPA00391.
BioCyciMHUN323259:GH0L-2874-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27890 / DSM 864 / NBRC 100397 / JF-1.

Entry informationi

Entry nameiQUEC_METHJ
AccessioniPrimary (citable) accession number: Q2FS65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 21, 2006
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.