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Q2FR24 (MCH_METHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methenyltetrahydromethanopterin cyclohydrolase
EC=3.5.4.27
Alternative name(s):
Methenyl-H4MPT cyclohydrolase
Gene names
Name:mch
Ordered Locus Names:Mhun_0444
OrganismMethanospirillum hungatei (strain JF-1 / DSM 864)
Taxonomic identifier323259 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of 5-formyl-H4MPT to methenyl-H4MPT+ By similarity. HAMAP MF_00486

Catalytic activity

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin. HAMAP MF_00486

Pathway

One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3. HAMAP MF_00486

Subcellular location

Cytoplasm By similarity HAMAP MF_00486.

Sequence similarities

Belongs to the MCH family.

Ontologies

Keywords
   Biological processMethanogenesis
One-carbon metabolism
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmethanogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

one-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmethenyltetrahydromethanopterin cyclohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Methenyltetrahydromethanopterin cyclohydrolase HAMAP MF_00486
PRO_1000014398

Sequences

Sequence LengthMass (Da)Tools
Q2FR24 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: D43F86E187FB26E9

FASTA31533,984
        10         20         30         40         50         60 
MISVNELALE IFDNLANYSE DFNVAYHELD NGAKIVDCGV SVPGGYAAGR AFTEICMGGL 

        70         80         90        100        110        120 
GEVNFRMGQI KHVPMPFIEV STDYPAISCL GAQKAGWTVK AGNYFAMGSG PARALALKPK 

       130        140        150        160        170        180 
HTYEVIGYED ESDDAVIALE SDHLPNGEVM EKIAKDCGID VENLCAVVAP TASLVGSIQV 

       190        200        210        220        230        240 
CGRCVETAVY KLNELGFDTR KITAAMGTAP IPPVKADATK AMGTTNDATI YHGQISLTMK 

       250        260        270        280        290        300 
APDIVDFLEK IPSNKSKGYG KPFYEIFKEA NFDFYQIDTS LFSPAEVTIN ELTEGKVYHV 

       310 
GEVNPDVTLK SFGYL

« Hide

References

[1]"Complete sequence of Methanospirillum hungatei JF-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-1 / DSM 864.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000254 Genomic DNA. Translation: ABD40206.1.
RefSeqYP_501925.1. NC_007796.1.

3D structure databases

ProteinModelPortalQ2FR24.
SMRQ2FR24. Positions 1-314.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2FR24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3925006.
GenomeReviewsGene locus Mhun_0444 in contig CP000254_GR.
KEGGmhu:Mhun_0444.
NMPDRfig|323259.5.peg.465.

Phylogenomic databases

eggNOGarNOG05033.
HOGENOMHBG497176.
OMAYFAMGSG.
ProtClustDBPRK02264.

Enzyme and pathway databases

BioCycMHUN323259:MHUN_0444-MONOMER.

Family and domain databases

HAMAPMF_00486. McH.
[Tree]
InterProIPR003209. METHMP_CycHdrlase.
[Graphical view]
KOK01499.
PfamPF02289. MCH. 1 hit.
[Graphical view]
SUPFAMSSF56199. Cyclohydrolase. 1 hit.
TIGRFAMsTIGR03120. One_C_mch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCH_METHJ
AccessionPrimary (citable) accession number: Q2FR24
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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