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Q2FR16 (ARLY_METHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Mhun_0084
OrganismMethanospirillum hungatei (strain JF-1 / DSM 864)
Taxonomic identifier323259 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Argininosuccinate lyase HAMAP MF_00006
PRO_0000240792

Sequences

Sequence LengthMass (Da)Tools
Q2FR16 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: BE43631250F5D593

FASTA49354,633
        10         20         30         40         50         60 
MTRDVVRKAR LSGERTEDIE SLLSSMEADR NIASSDVLVD MAHLVMLTRQ QIVHEDHAKT 

        70         80         90        100        110        120 
LMKELLCMYE SGVPAEAFDP SYEDIHAGIE TILTRKTGGD VGGRLHIGRS RNDEVATCLR 

       130        140        150        160        170        180 
IRTRDIILDQ LEALTRLRSV LLSVAADHIT TVMPGFTHLQ HAQPVTLAHH LLAYEQMFSR 

       190        200        210        220        230        240 
DFDRLFDALR RVNCSPLGSA ALASTGYPLD RPFTADLLGF DRILVNSMDA VASRDFAEET 

       250        260        270        280        290        300 
LACDTMLLTN ISRFCEELII WSSAFVQFVN LDDRYCSTSS IMPQKKNPDV AEILRSRTGT 

       310        320        330        340        350        360 
ILGSFVSAIT IVKGLPMAYN RDLQDLNPHL WRGITGVRRD IDLLAGMVES ATFNRERMAE 

       370        380        390        400        410        420 
EAGRGGTTTT ELADTLVREF NIPFRTAHHI VGKAVKDGSL DLVTLDRGAE EFYGKTLSSL 

       430        440        450        460        470        480 
GVTQKNIDSA LSVSTSLSVR KLPGGPAPDA VLDALAERRK ELEKDIELIC DKKTQISASL 

       490 
HELLTQARRI AQL

« Hide

References

[1]"Complete sequence of Methanospirillum hungatei JF-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-1 / DSM 864.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000254 Genomic DNA. Translation: ABD39862.1.
RefSeqYP_501581.1. NC_007796.1.

3D structure databases

ProteinModelPortalQ2FR16.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2FR16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3922197.
GenomeReviewsGene locus Mhun_0084 in contig CP000254_GR.
KEGGmhu:Mhun_0084.
NMPDRfig|323259.5.peg.85.

Phylogenomic databases

eggNOGarNOG04975.
HOGENOMHBG539632.
OMAEDIHTVI.
PhylomeDBQ2FR16.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMHUN323259:MHUN_0084-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_METHJ
AccessionPrimary (citable) accession number: Q2FR16
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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