ID   AROD_METHJ              Reviewed;         256 AA.
AC   Q2FQV3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   05-MAY-2009, entry version 22.
DE   RecName: Full=3-dehydroquinate dehydratase;
DE            Short=3-dehydroquinase;
DE            EC=4.2.1.10;
DE   AltName: Full=Type I DHQase;
GN   Name=aroD; OrderedLocusNames=Mhun_0979;
OS   Methanospirillum hungatei (strain JF-1 / DSM 864).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanomicrobiales;
OC   Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D.,
RA   Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J.,
RA   Stams A.J.M., Boone D.R., Richardson P.;
RT   "Complete sequence of Methanospirillum hungatei JF-1.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 3/7.
CC   -!- SIMILARITY: Belongs to the type-I 3-dehydroquinase family.
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DR   EMBL; CP000254; ABD40729.1; -; Genomic_DNA.
DR   RefSeq; YP_502448.1; -.
DR   GeneID; 3923623; -.
DR   GenomeReviews; CP000254_GR; Mhun_0979.
DR   KEGG; mhu:Mhun_0979; -.
DR   NMPDR; fig|323259.5.peg.1032; -.
DR   HOGENOM; Q2FQV3; -.
DR   OMA; Q2FQV3; YARDERE.
DR   BioCyc; MHUN323259:MHUN_0979-MON; -.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   HAMAP; MF_00214; -; 1.
DR   InterPro; IPR018508; 3-dehydroquinate_DH_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001381; DHquinase_I.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF01487; DHquinase_I; 1.
DR   ProDom; PD005337; DHquinase_I; 1.
DR   PROSITE; PS01028; DEHYDROQUINASE_I; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Schiff base.
FT   CHAIN         1    256       3-dehydroquinate dehydratase.
FT                                /FTId=PRO_0000325540.
FT   ACT_SITE    122    122       Proton acceptor (By similarity).
FT   ACT_SITE    147    147       Schiff-base intermediate with substrate
FT                                (By similarity).
SQ   SEQUENCE   256 AA;  28756 MW;  4BC9505875F479C0 CRC64;
     MTSDALKADP NRLIKIIASL SSTRELLSPE VTKADALEIR LDLITEPIDD ALHSLRTSFQ
     GPMVLTVRSS DEGGAYAGGS AGLWKKLEPY IGLVDIIDLE IRFKDHAPQV KEHNKAIIAS
     CHQNRMPDDD EMQALIEELH SFGDIVKIAV QPQTKEDVIR LLKITAACPY PIIMSVTGTV
     YRYARPLLCL FGSLYTYCYI HSETSPGQYS LREMQLLAHL LSPGFVDPWF EGRPVRSGDA
     SGYYERAEQY RKHLEF
//