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Protein

D-aminoacyl-tRNA deacylase

Gene

dtdA

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.UniRule annotation

Catalytic activityi

A D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
D-aminoacyl-tRNA deacylaseUniRule annotation (EC:3.1.1.96UniRule annotation)
Alternative name(s):
D-tyrosyl-tRNA(Tyr) deacylase
Gene namesi
Name:dtdAUniRule annotation
Ordered Locus Names:Mhun_0661
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003452241 – 442D-aminoacyl-tRNA deacylaseAdd BLAST442

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi323259.Mhun_0661.

Structurei

3D structure databases

ProteinModelPortaliQ2FPX3.
SMRiQ2FPX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DtdA deacylase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01616. Archaea.
COG1650. LUCA.
HOGENOMiHOG000087623.
KOiK09716.
OMAiCTHHGPT.
OrthoDBiPOG093Z07LR.

Family and domain databases

HAMAPiMF_00562. Deacylase_DtdA. 1 hit.
InterProiView protein in InterPro
IPR018033. Deacylase_DtdA_archaea.
IPR007508. DtdA.
PfamiView protein in Pfam
PF04414. tRNA_deacylase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FPX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPKEQSPTT LLISSRKDPA GSLIHEELYS FLEDDKRAHS HIRHWHAEER
60 70 80 90 100
LIYLDGPSLP HDADRILFLS RHASERPRPV LTVHVTGNFG SADYGGRPNT
110 120 130 140 150
LTPAATGLMH ALINRLIIHA PEGYEVMYEA THHGPTDIPL PSCFIELGST
160 170 180 190 200
EKEWNDRIAA RAVAQAVLDA LLMDTSSVIP LAGFGGTHYA QRQTEITKLT
210 220 230 240 250
RGGFGHIMPT RDIPHLTDAL FQDIISSTGA FAIYIDGKSM SGKEERMITG
260 270 280 290 300
LADKHTIPIL GQGDLMRLFD LPFSEYMSIR NLAESLIPGS SIVLHTILEM
310 320 330 340 350
PAPVSLTIPG ELVDEVMKVA AEEFISALDS FPIVHMTGRG KACHPVFITD
360 370 380 390 400
AAFSGRISDE LIHLCVTLLQ DRYTCSFEGD SLIIKKLRFD PKKAKNLGIP
410 420 430 440
SGPLYSELMA GKPVEVGDSV IYPEMVMTET EKRIHIPQRQ AR
Length:442
Mass (Da):48,825
Last modified:March 21, 2006 - v1
Checksum:i0A694E67744F24EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD40417.1.
RefSeqiWP_011447701.1. NC_007796.1.

Genome annotation databases

EnsemblBacteriaiABD40417; ABD40417; Mhun_0661.
GeneIDi3923578.
KEGGimhu:Mhun_0661.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDTDA_METHJ
AccessioniPrimary (citable) accession number: Q2FPX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 21, 2006
Last modified: June 7, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families