Q2FNQ9 (DAPB_METHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Mhun_1493

Organism

Methanospirillum hungatei (strain JF-1 / DSM 864)

Taxonomic identifier

323259 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008587

Sequences

	Sequence		Length	Mass (Da)
	Q2FNQ9 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 8767958DE4C435DB	FASTA	254	27,510
	10 20 30 40 50 60 MIKVVICGAF GRMGTIIGEI ISKEQDMQLV GGVDIKEGTF FGVPVVTSDK LADFLSSVQP 70 80 90 100 110 120 DVVIDFTVAP AAAQNVPVAA RAGCAIILGT TGLTQEQRKG IDAAIREGKV PAVISTNYSI 130 140 150 160 170 180 GMNILWTLIR DAARKLSDYD VEVIEAHHRY KKDAPSGTAR TILQILQEEI GPREEIYGRE 190 200 210 220 230 240 GMTERSSEIG VHVIRGGDIV GDHAVMFASN FETVTLSHRA YDRSVFAEGA VRATRWVFGK 250 EPGIYGMKDV LNLS

References

[1]

"Complete sequence of Methanospirillum hungatei JF-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-1 / DSM 864.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000254 Genomic DNA. Translation: ABD41227.1.
RefSeq	YP_502946.1. NC_007796.1.
3D structure databases
HSSP	HSSP built from PDB template 1VM6 based on UniProtKB Q9X1K8.
ProteinModelPortal	Q2FNQ9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FNQ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3922724.
GenomeReviews	Gene locus Mhun_1493 in contig CP000254_GR.
KEGG	mhu:Mhun_1493.
NMPDR	fig|323259.5.peg.1581.
Phylogenomic databases
eggNOG	arNOG05038.
HOGENOM	HBG594002.
OMA	MVRVILN.
PhylomeDB	Q2FNQ9.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	MHUN323259:MHUN_1493-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_METHJ

Accession

Primary (citable) accession number: Q2FNQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program