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Q2FNB7 (MPTA_METHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2
Gene names
Name:mptA
Ordered Locus Names:Mhun_2334
OrganismMethanospirillum hungatei (strain JF-1 / DSM 864) [Reference proteome] [HAMAP]
Taxonomic identifier323259 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum ›

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Pathway

Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionGTP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328GTP cyclohydrolase MptA HAMAP-Rule MF_01527
PRO_0000289541

Sites

Site1711May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2FNB7 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 5338252B90362DE9

FASTA32836,818
        10         20         30         40         50         60 
MSLLKTSERG FSRELPDVQS TLPDVRINLT RVGVKNVKKL VEVTRPGKRP VIFISNFDIF 

        70         80         90        100        110        120 
VDLPGSLKGA NLSRNFEVID EVLQSAIEGE VKEIEQLCSR VARRLLDKHE YADRTEVQMR 

       130        140        150        160        170        180 
SEFMVAGETP VTGTLCQEVV KVFASAIAQR TFKDPIVRKS IGAEVTGMTA CPCAQNIMQE 

       190        200        210        220        230        240 
RAREVMENLD IAKDKIESFF KEVPMATHNQ RGRGFLSIET DDESHVKLEK IIMILKQSMS 

       250        260        270        280        290        300 
TPIFELLKRG DEGHVVLSAH KNPRFVEDCV REMARRVHAE FGDLPGDSVV TIAQDNEESI 

       310        320 
HQHDAFAERQ ATIAELADEI NGENLDVS

« Hide

References

[1]"Complete sequence of Methanospirillum hungatei JF-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-1 / DSM 864.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000254 Genomic DNA. Translation: ABD42038.1.
RefSeqYP_503757.1. NC_007796.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING323259.Mhun_2334.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD42038; ABD42038; Mhun_2334.
GeneID3923052.
KEGGmhu:Mhun_2334.

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280680.
KOK09007.
OMAVEDCVRE.
ProtClustDBPRK13675.

Enzyme and pathway databases

BioCycMHUN323259:GH0L-2390-MONOMER.
UniPathwayUPA00065.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_A. GTP_cyclohydrol_A.
InterProIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPTA_METHJ
AccessionPrimary (citable) accession number: Q2FNB7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 21, 2006
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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