Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q2FN16 (Q2FN16_METHJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase 1 HAMAP MF_00079
Short name=ATP-PRT 1 HAMAP MF_00079
Short name=ATP-PRTase 1 HAMAP MF_00079
EC=2.4.2.17 HAMAP MF_00079
Gene names
Name:hisG1 HAMAP MF_00079
Ordered Locus Names:Mhun_0922
OrganismMethanospirillum hungatei (strain JF-1 / DSM 864)
Taxonomic identifier323259 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity By similarity. HAMAP MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079

Cofactor

Magnesium By similarity. HAMAP MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079

Subcellular location

Cytoplasm By similarity HAMAP MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP MF_00079

Sequences

Sequence LengthMass (Da)Tools
Q2FN16 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: FB1432EE8A81492A

FASTA30032,569
        10         20         30         40         50         60 
MTKNSSPISD RTPVFHVRIA IPNKGRISVP IRELIEKSGL GIIDNGDRTL IARTRDQHVE 

        70         80         90        100        110        120 
ILYARPIDIP EYVASGVADL GITGHDMVVE RGSAVTELLN LGFGSASVVL AVPENSNLNS 

       130        140        150        160        170        180 
PKDLNGKRVS TEFPAITRKY FKKAGIIPII VPVGGACEAT PSLGISDAIV DISSSGSTLR 

       190        200        210        220        230        240 
QNHLKIIDTV LETSTYLIAN PRSCIDKKEK IDEIHLALES VLNARGKCYL MMNVIRSSLD 

       250        260        270        280        290        300 
DIRTIIPGMG GPTIMDVASS ADMVAVHAVV DEEKVYQLIN RLKQAGARDI LVMNIERLIR

« Hide

References

[1]"Complete sequence of Methanospirillum hungatei JF-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-1 / DSM 864.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000254 Genomic DNA. Translation: ABD40672.1.
RefSeqYP_502391.1. NC_007796.1.

3D structure databases

ProteinModelPortalQ2FN16.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2FN16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3924609.
GenomeReviewsGene locus Mhun_0922 in contig CP000254_GR.
KEGGmhu:Mhun_0922.
NMPDRfig|323259.5.peg.974.

Phylogenomic databases

eggNOGarNOG04876.
HOGENOMHBG391868.
OMAIMLHAPS.
PhylomeDBQ2FN16.
ProtClustDBPRK00489.

Family and domain databases

HAMAPMF_00079. HisG_Long.
[Tree]
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
Gene3DG3DSA:3.30.70.120. PII_glnB. 1 hit.
KOK00765.
PANTHERPTHR21403. ATP_phspho_trans. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. HisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2FN16_METHJ
AccessionPrimary (citable) accession number: Q2FN16
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info