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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbon dioxide fixation
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:Mhun_0174
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003096051 – 484Phosphoenolpyruvate carboxylaseAdd BLAST484

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi323259.Mhun_0174.

Structurei

3D structure databases

SMRiQ2FLH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04435. Archaea.
COG1892. LUCA.
HOGENOMiHOG000038601.
KOiK01595.
OrthoDBiPOG093Z01LI.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2. 1 hit.
InterProiView protein in InterPro
IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
PfamiView protein in Pfam
PF14010. PEPcase_2. 1 hit.
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FLH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIPRTMSTQ HPDNVHTPFF TENIELTGED EVKEAYYVYS HLGCTEQMWD
60 70 80 90 100
CEGKEVDNYV VKKLLSRYGD YFKEHHLGRD LFLTLRVPNP EIERTEAKIL
110 120 130 140 150
LETLGSIPRS YDVAHHFYND TYAPIFEIIL PMTTSFASID NIYQYYCDFV
160 170 180 190 200
IGQQYKRLGG RDLTIAEWIG PFHPDKIRVI PLFEDKDGML AADTILRRYF
210 220 230 240 250
QDKDLDYQRV FLARSDPAVN YGQIGAVLLN KIALWRLHLL SEDTGIPVYP
260 270 280 290 300
IIGAGSAPFR GNLRPDTVRR VTDEYAGAYT FTIQSAFKYD TNLEEAVSAI
310 320 330 340 350
RYLEEREITP AREIDDTYAI SLIERYAAGY QKQIRSLAPL INRVAAYIPS
360 370 380 390 400
RRKRKLHVGL FGYSRNMGGV SLPRAITVTA ALYSIGIPPE VLGLSALTEN
410 420 430 440 450
DREFVLENYR YVTEDLSDAC RYLNPDSSFL PDEIKKILPD WIEIDPHSEH
460 470 480
RVLSGQIEKA VTACQIDSVQ DMIIRAGAIR KFLG
Length:484
Mass (Da):55,411
Last modified:May 3, 2011 - v2
Checksum:i9EAF45C89E40AC3B
GO

Sequence cautioni

The sequence ABD39949 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD39949.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABD39949; ABD39949; Mhun_0174.
KEGGimhu:Mhun_0174.

Similar proteinsi

Entry informationi

Entry nameiCAPPA_METHJ
AccessioniPrimary (citable) accession number: Q2FLH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 3, 2011
Last modified: November 22, 2017
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families