ID   Q2FLF1_METHJ            Unreviewed;       625 AA.
AC   Q2FLF1;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   OrderedLocusNames=Mhun_0567 {ECO:0000313|EMBL:ABD40327.1};
OS   Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS   JF-1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259 {ECO:0000313|EMBL:ABD40327.1, ECO:0000313|Proteomes:UP000001941};
RN   [1] {ECO:0000313|Proteomes:UP000001941}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1
RC   {ECO:0000313|Proteomes:UP000001941};
RX   PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA   Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA   Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA   Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT   "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL   Stand. Genomic Sci. 11:2-2(2016).
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DR   EMBL; CP000254; ABD40327.1; -; Genomic_DNA.
DR   RefSeq; WP_011447613.1; NC_007796.1.
DR   AlphaFoldDB; Q2FLF1; -.
DR   STRING; 323259.Mhun_0567; -.
DR   EnsemblBacteria; ABD40327; ABD40327; Mhun_0567.
DR   GeneID; 3923144; -.
DR   KEGG; mhu:Mhun_0567; -.
DR   eggNOG; arCOG04201; Archaea.
DR   HOGENOM; CLU_000022_3_6_2; -.
DR   InParanoid; Q2FLF1; -.
DR   Proteomes; UP000001941; Chromosome.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ABD40327.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001941}.
FT   DOMAIN          24..77
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          79..468
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          524..602
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   625 AA;  70364 MW;  6D0837F0DF58C195 CRC64;
     MHKPEQKVYY PDPCYRDSAL IHDYNELYYE FEKDPDAFWR RIASDLLWFK QWNNVKVWNH
     PYASWFTGAE LNITYNCLER HVNNDRRNKV AIFWAGENGR ERIFTYYQLY KDVMRMGNAL
     KSLGVQKGDR VCIYLPGIPE LVVSMLACAR IGAVHTVVFA GYGAKALNER ITGAGAKIVI
     TADASVRRGG SIPLKPIVEE ALINAPTVER VIILRTQEPK VGLLDEFELD YEELIAQADR
     YCEPVHVNSE DPLFILYTSG TTGAPKGIVH AAGGYMVGAY YTTKYVLTLR ENDVYWCTAD
     PGWITGHTYG IYGPLLVGGT IFLSEYTPDY PDAGIWWKLI EDYGVTIFYT APTAIRMFMR
     MGEEWPDKYD LSSLRLLGSV GEPLNPEAFE WFYKHIGKNK CPILDTWWQT ETGMHMVTTM
     VGLPMKPGFA GKPIPGVIAT VVNEEGDPIP PGTTGYLAIK EPWPSMMKAV YQNDERYRQY
     WSFGKYGYYS SNDLAVMDED GYIMLLGRSD DIIIVAGHNV GTAEIESALV SHSAVAEAAA
     IGKPDPLKGN IIKAFVILRN GVEPSQKLIH DLKYHVRIML GPISVPAELD FVDSLPKTRS
     GKIMRRVLKA KEMGMDPGDI STLDE
//