Q2FLE8 (SURE_METHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Mhun_0570

Organism

Methanospirillum hungatei (strain JF-1 / DSM 864)

Taxonomic identifier

323259 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanospirillaceae › Methanospirillum

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235679
Sites
	Metal binding	28	1	Divalent metal cation By similarity
	Metal binding	29	1	Divalent metal cation By similarity
	Metal binding	59	1	Divalent metal cation By similarity
	Metal binding	113	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2FLE8 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 7D492624C2F1919C	FASTA	279	30,199
	10 20 30 40 50 60 MISGSPPDST PSHHHFSLKR PCILLTNDDG VNSEGLWAAY DALFEWADVV VCAPATQQSA 70 80 90 100 110 120 VGRSLSIFEP LRVNTVSRGD ITAYAVGGKP TDSVILALFA LGVKPDLVVS GINIGENLSY 130 140 150 160 170 180 EAITTSGTVG AALEAANHGY PAVAFSLQIE DQKEKFDDAR HLADRFSESK GVVRDVIRRI 190 200 210 220 230 240 LEKGFPSFTH VMNVNIPSII TGGYEITHLA EHLFITGVEK RLDPRGKPYY WINGPLVTDA 250 260 270 PEGTDVHAIH KGNISITPIT LDCTAYAGTD DLRRLFSLE

References

[1]

"Complete sequence of Methanospirillum hungatei JF-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., McInerney M.J., Brockman F., Culley D., Ferry J.G., Gunsalus R.P., Morrison M., Plugge C., Scholten J., Stams A.J.M., Boone D.R., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-1 / DSM 864.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000254 Genomic DNA. Translation: ABD40330.1.
RefSeq	YP_502049.1. NC_007796.1.
3D structure databases
ProteinModelPortal	Q2FLE8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FLE8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3923147.
GenomeReviews	Gene locus Mhun_0570 in contig CP000254_GR.
KEGG	mhu:Mhun_0570.
NMPDR	fig|323259.5.peg.600.
Phylogenomic databases
eggNOG	arNOG05083.
HOGENOM	HBG600532.
OMA	SINVIYS.
PhylomeDB	Q2FLE8.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	MHUN323259:MHUN_0570-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_METHJ

Accession

Primary (citable) accession number: Q2FLE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 21, 2006
Last modified:	November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program