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Protein

CDP-archaeol synthase

Gene

carS

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMHUN323259:GH0L-1128-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-archaeol synthaseUniRule annotation (EC:2.7.7.67UniRule annotation)
Alternative name(s):
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthaseUniRule annotation
Gene namesi
Name:carSUniRule annotation
Ordered Locus Names:Mhun_1107
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei61 – 8121HelicalUniRule annotationAdd
BLAST
Transmembranei104 – 12421HelicalUniRule annotationAdd
BLAST
Transmembranei127 – 14721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166CDP-archaeol synthasePRO_0000298282Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323259.Mhun_1107.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDP-archaeol synthase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG04106. Archaea.
COG0575. LUCA.
HOGENOMiHOG000226016.
KOiK19664.

Family and domain databases

HAMAPiMF_01117. CDP_archaeol_synth. 1 hit.
InterProiIPR032690. CarS.
IPR002726. CarS_archaea.
[Graphical view]
PfamiPF01864. DUF46. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FLB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAYLPNNF AALTGGGMPI DMGRNWTDGR RILGDGKTIR GFVGGVTAGI
60 70 80 90 100
LIGAVQMYAE ISGLVPWFPP HTLTAVILLA IGSLLGDMVK SFFKRRQGID
110 120 130 140 150
RGGEWFLVDQ LDFVVGALLL TLLFDPIWML NTMTIPLLIV ILVLTPLLHR
160
TVNIIGYKLG LKKVPW
Length:166
Mass (Da):18,185
Last modified:August 21, 2007 - v2
Checksum:iD1CDE2E0290F211B
GO

Sequence cautioni

The sequence ABD40856 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD40856.1. Different initiation.
RefSeqiWP_048067819.1. NC_007796.1.

Genome annotation databases

EnsemblBacteriaiABD40856; ABD40856; Mhun_1107.
GeneIDi3922140.
KEGGimhu:Mhun_1107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA. Translation: ABD40856.1. Different initiation.
RefSeqiWP_048067819.1. NC_007796.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323259.Mhun_1107.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD40856; ABD40856; Mhun_1107.
GeneIDi3922140.
KEGGimhu:Mhun_1107.

Phylogenomic databases

eggNOGiarCOG04106. Archaea.
COG0575. LUCA.
HOGENOMiHOG000226016.
KOiK19664.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciMHUN323259:GH0L-1128-MONOMER.

Family and domain databases

HAMAPiMF_01117. CDP_archaeol_synth. 1 hit.
InterProiIPR032690. CarS.
IPR002726. CarS_archaea.
[Graphical view]
PfamiPF01864. DUF46. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDPAS_METHJ
AccessioniPrimary (citable) accession number: Q2FLB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 16, 2016
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.