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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. no protein annotated in this organism
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMHUN323259:G1G5Z-1898-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:Mhun_1790Imported
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)Imported
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi323259.Mhun_1790

Structurei

3D structure databases

ProteinModelPortaliQ2FKX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 374PALPInterPro annotationAdd BLAST326

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01433 Archaea
COG0133 LUCA
HOGENOMiHOG000161710
KOiK01696
OMAiHGMKSYF
OrthoDBiPOG093Z03B1

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FKX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLNTRLGEY GGCFVPETLM GALEELEDAF LKIFPGSAFQ KELSKYLTTY
60 70 80 90 100
AGRETPLTFC NNMSRDLGCR VYLKREDLLH SGAHKMNNAL GQALLAKYMG
110 120 130 140 150
KKRLIAETGA GQHGVATAIA GAVLGLEVDV FMGEVDIARQ ALNVARMNMM
160 170 180 190 200
GARVIPVTCG TRTLKDAMNE ALRDWVARVL DTHYLIGTVA GPHPYPTLVR
210 220 230 240 250
DLQRVIGDET KKQILAAEGR LPDVIIACIG GGSNAIGIFH PFIEDKAVRM
260 270 280 290 300
YGVEAGGEGL DRKHGASLCG GRPGVLHGNY SYLLQDAFGQ IIESHSISAG
310 320 330 340 350
LDYPGVGPEH AMHKDSGRIT YTAITDTEAL EAFLYLCRTE GIVPALESSH
360 370 380 390
AVAFARKLAP DLSEDTIIVI NLSGRGDKDV ETVRRYMEGK Q
Length:391
Mass (Da):42,383
Last modified:March 21, 2006 - v1
Checksum:i46929C7C587B80AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD41511.1
RefSeqiWP_011448775.1, NC_007796.1

Genome annotation databases

EnsemblBacteriaiABD41511; ABD41511; Mhun_1790
GeneIDi3924439
KEGGimhu:Mhun_1790

Similar proteinsi

Entry informationi

Entry nameiQ2FKX7_METHJ
AccessioniPrimary (citable) accession number: Q2FKX7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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