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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. no protein annotated in this organism
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Proton acceptorUniRule annotation1
Active sitei57Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciMHUN323259:G1G5Z-1899-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:Mhun_1791Imported
OrganismiMethanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)Imported
Taxonomic identifieri323259 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanospirillaceaeMethanospirillum
Proteomesi
  • UP000001941 Componenti: Chromosome

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi323259.Mhun_1791

Structurei

3D structure databases

ProteinModelPortaliQ2FKX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01086 Archaea
COG0159 LUCA
HOGENOMiHOG000223814
KOiK01695
OMAiDYPPEEC
OrthoDBiPOG093Z08H9

Family and domain databases

CDDicd04724 Tryptophan_synthase_alpha, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00131 Trp_synth_alpha, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011060 RibuloseP-bd_barrel
IPR018204 Trp_synthase_alpha_AS
IPR002028 Trp_synthase_suA
PfamiView protein in Pfam
PF00290 Trp_syntA, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00262 trpA, 1 hit
PROSITEiView protein in PROSITE
PS00167 TRP_SYNTHASE_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FKX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLKEAFET RTKSLLMTFT VAGDPDFETS LEIIKALENG GADIIELGLP
60 70 80 90 100
FSDPVADGPV IQQADQRALA SGMNTDRFFD LVREVRKSSD IPLVVLTYTN
110 120 130 140 150
LILQRDINTF YQDAADAGID AVVVADLPYE EAGPYITAAE TAGVAPVMMV
160 170 180 190 200
STTTSPERLS KILTVKSGFI YLVAALGVTG MRQKTDPVAQ KLLADLKNRT
210 220 230 240 250
DIPIAPGFGI SDREQVREWT DAGADAVIVG SALVREIEDS LVKPDTLIPR

ITAFVQSLK
Length:259
Mass (Da):28,046
Last modified:March 21, 2006 - v1
Checksum:i52452A3CB54A8B51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000254 Genomic DNA Translation: ABD41512.1
RefSeqiWP_011448776.1, NC_007796.1

Genome annotation databases

EnsemblBacteriaiABD41512; ABD41512; Mhun_1791
GeneIDi3924440
KEGGimhu:Mhun_1791

Similar proteinsi

Entry informationi

Entry nameiQ2FKX6_METHJ
AccessioniPrimary (citable) accession number: Q2FKX6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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