Reviewed, UniProtKB/Swiss-Prot Q2FK94 (ALDA_STAA3)

Names and originHide

Protein names

Recommended name:
Putative aldehyde dehydrogenase AldA
EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	SAUSA300_0170

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributesHide

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

OntologiesHide

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Putative aldehyde dehydrogenase AldA		PRO_0000290789
Regions
	Nucleotide binding	212 – 218	7	NAD By similarity
Sites
	Active site	256	1	By similarity
	Active site	290	1	By similarity

SequencesHide

	Sequence		Length	Mass (Da)
	Q2FK94-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: DCBE4F433645A52A	FASTA	495	53,659
	10 20 30 40 50 60 MAVNVRDYIA ENYGLFINGE FVKGSSDETI EVTNPATGET LSHITRAKDK DVDHAVKVAQ 70 80 90 100 110 120 EAFESWSLTS KSERAQMLRD IGDKLMAQKD KIAMIETLNN GKPIRETTAI DIPFAARHFH 130 140 150 160 170 180 YFASVIETEE GTVNDIDKDT MSIVRHEPIG VVGAVVAWNF PMLLAAWKIA PAIAAGNTIV 190 200 210 220 230 240 IQPSSSTPLS LLEVAKIFQE VLPKGVVNIL TGKGSESGNA IFNHDGVDKL SFTGSTDVGY 250 260 270 280 290 300 QVAEAAAKHL VPATLELGGK SANIILDDAN LDLAVEGIQL GILFNQGEVC SAGSRLLVHE 310 320 330 340 350 360 KIYDQLVPRL QEAFSNIKVG NPQDEATQMG SQTGKDQLDK IQSYIDAAKE SDAQILAGGH 370 380 390 400 410 420 RLTENGLDKG FFFEPTLIAV PDNHHKLAQE EIFGPVLTVI KVKDDQEAID IANDSEYGLA 430 440 450 460 470 480 GGVFSQNITR ALNIAKAVRT GRIWINTYNQ VPEGAPFGGY KKSGIGRETY KGALSNYQQV 490 KNIYIDTSNA LKGLY

ReferencesHide

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	CP000255 Genomic DNA. Translation: ABD21998.1.
RefSeq	YP_492884.1.
3D structure databases
HSSP	HSSP built from PDB template 2D4E based on UniProtKB Q5SJP9.
SMR	Q2FK94. Positions 14-489.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FK94.
Genome annotation databases
EnsemblBacteria	EBSTAT00000037753; EBSTAP00000036461; EBSTAG00000037751.
GeneID	3913223.
GenomeReviews	Gene locus SAUSA300_0170 in contig CP000255_GR.
KEGG	saa:SAUSA300_0170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	AQDAFES.
ProtClustDB	CLSK884447.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry informationHide

Entry name

ALDA_STAA3

Accession

Primary (citable) accession number: Q2FK94

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	March 21, 2006
Last modified:	July 13, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)