true2007-01-092024-01-2497PFLA_STAA3Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus.Diep B.A.Gill S.R.Chang R.F.Phan T.H.Chen J.H.Davidson M.G.Lin F.Lin J.Carleton H.A.Mongodin E.F.Sensabaugh G.F.Perdreau-Remington F.doi:10.1016/s0140-6736(06)68231-72006Lancet367731-739NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]USA300Radical_SAMAldolase class IAldolase_TIMBssD/PflA/YjjWOrganic_radical-activatingOrganic_radical_activasePFL1_activatingPyruvate_for-lyase_activaseRadical_activat_CSrSAMPFLAPYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYMEPYRUVATE FORMATE-LYASE-ACTIVATING ENZYMEFer4_12Radical_SAMPFL_act_enzactivating_enzymes__group_2pyruvate_formate-lyase_activasRadical SAM enzymesRADICAL_ACTIVATINGRADICAL_SAMPyruvate formate-lyase-activating enzymePFL-activating enzyme1.97.1.4pflASAUSA300_0221Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.Belongs to the organic radical-activating enzymes family.Pyruvate formate-lyase-activating enzyme284991251Radical SAM core152442933353736791341362074Fe-4S-S-AdoMet2006-03-21128499d866a35db1291191c188e76858ed1f96MLKGHLHSVESLGTVDGPGLRYILFTQGCLLRCLYCHNPDTWKISEPSREVTVDEMVNEILPYKPYFDASGGGVTVSGGEPLLQMPFLEKLFAELKENGVHTCLDTSAGCANDTKAFQRHFEELQKHTDLILLDIKHIDNDKHIRLTGKPNTHILNFARKLSDMKQPVWIRHVLVPGYSDDKDDLIKLGEFINSLDNVEKFEILPYHQLGVHKWKTLGIAYELEDVEAPDDEAVKAAYRYVNFKGKIPVELtruetruetruetrue