Reviewed, UniProtKB/Swiss-Prot Q2FJU6 (NANE_STAA3)

Names and origin

Protein names

Recommended name:
    Putative N-acetylmannosamine-6-phosphate 2-epimerase
    EC=5.1.3.9
Alternative name(s):
    ManNAc-6-P epimerase

Gene names

Name:	nanE
Ordered Locus Names:	SAUSA300_0318

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Potential.
Catalytic activity	N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01235
Pathway	Amino-sugar metabolism; N-acetylneuraminic acid degradation; D-fructose 6-phosphate from N-acetylneuraminic acid: step 3/5. HAMAP MF_01235
Sequence similarities	Belongs to the nanE family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	N-acylglucosamine-6-phosphate 2-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Putative N-acetylmannosamine-6-phosphate 2-epimerase HAMAP MF_01235		PRO_0000301486

Sequences

	Sequence		Length	Mass (Da)
	Q2FJU6-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 7417D8DD1A48A041	FASTA	222	24,545
	10 20 30 40 50 60 MLPHGLIVSC QALPDEPLHS SFIMSKMALA AYEGGAVGIR ANTKEDILAI KETVDLPVIG 70 80 90 100 110 120 IVKRDYDHSD VFITATSKEV DELIESQCEV IALDATLQQR PKETLDELVS YIRTHAPNVE 130 140 150 160 170 180 IMADIATVEE AKNAARLGFD YIGTTLHGYT SYTQGQLLYQ NDFQFLKDVL QSVDAKVIAE 190 200 210 220 GNVITPDMYK RVMDLGVHCS VVGGAITRPK EITKRFVQIM ED

References

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000255 Genomic DNA. Translation: ABD21297.1.
RefSeq	YP_493032.1.
3D structure databases
SMR	Q2FJU6. Positions 1-221.
ModBase	Search...
Genome annotation databases
GeneID	3913041.
GenomeReviews	Gene locus SAUSA300_0318 in contig CP000255_GR.
KEGG	saa:SAUSA300_0318.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FJU6.
OMA	Q2FJU6. YNTPELA.
Family and domain databases
HAMAP	MF_01235. [Tree]
InterPro	IPR007260. NanE. [Graphical view]
Pfam	PF04131. NanE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NANE_STAA3

Accession

Primary (citable) accession number: Q2FJU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)