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Q2FJH7

- SLE1_STAA3

UniProt

Q2FJH7 - SLE1_STAA3

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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene
sle1, aaa, SAUSA300_0438
Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-438-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SAUSA300_0438
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001939: Chromosome

Subcellular locationi

Secreted By similarity. Cell surface By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 334309N-acetylmuramoyl-L-alanine amidase sle1PRO_0000271076Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi451515.SAUSA300_0438.

Structurei

3D structure databases

ProteinModelPortaliQ2FJH7.
SMRiQ2FJH7. Positions 228-334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 7143LysM 1Add
BLAST
Repeati93 – 13543LysM 2Add
BLAST
Repeati160 – 20243LysM 3Add
BLAST
Domaini210 – 334125Peptidase C51Add
BLAST

Sequence similaritiesi

Contains 3 LysM repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiEMNYSAS.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FJH7-1 [UniParc]FASTAAdd to Basket

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MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK    50
LKSLNNLTSN LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS 100
LSLIASKYGT TYQNIMRLNG LNNFFIYPGQ KLKVSGTASS SNAASNSSRP 150
STNSGGGSYY TVQAGDSLSL IASKYGTTYQ KIMSLNGLNN FFIYPGQKLK 200
VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF NRRAEIGKGI 250
STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND 300
GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH 334
Length:334
Mass (Da):35,836
Last modified:March 21, 2006 - v1
Checksum:i4C1E30AD9DE61D36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD20550.1.
RefSeqiYP_493151.1. NC_007793.1.

Genome annotation databases

EnsemblBacteriaiABD20550; ABD20550; SAUSA300_0438.
GeneIDi3912915.
KEGGisaa:SAUSA300_0438.
PATRICi19590140. VBIStaAur129981_0510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD20550.1 .
RefSeqi YP_493151.1. NC_007793.1.

3D structure databases

ProteinModelPortali Q2FJH7.
SMRi Q2FJH7. Positions 228-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 451515.SAUSA300_0438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD20550 ; ABD20550 ; SAUSA300_0438 .
GeneIDi 3912915.
KEGGi saa:SAUSA300_0438.
PATRICi 19590140. VBIStaAur129981_0510.

Phylogenomic databases

eggNOGi COG3942.
HOGENOMi HOG000279823.
OMAi EMNYSAS.
OrthoDBi EOG6GTZPF.

Enzyme and pathway databases

BioCyci SAUR451515:GH3C-438-MONOMER.

Family and domain databases

Gene3Di 3.10.350.10. 3 hits.
InterProi IPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view ]
Pfami PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view ]
SMARTi SM00257. LysM. 3 hits.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 3 hits.
PROSITEi PS50911. CHAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiSLE1_STAA3
AccessioniPrimary (citable) accession number: Q2FJH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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