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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-438-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SAUSA300_0438
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 334309N-acetylmuramoyl-L-alanine amidase sle1PRO_0000271076Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2FJH7.
SMRiQ2FJH7. Positions 28-201, 228-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 7143LysM 1Add
BLAST
Repeati93 – 13543LysM 2Add
BLAST
Repeati160 – 20243LysM 3Add
BLAST
Domaini210 – 334125Peptidase C51PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 LysM repeats.Curated
Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiEMNYSAS.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FJH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK
60 70 80 90 100
LKSLNNLTSN LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS
110 120 130 140 150
LSLIASKYGT TYQNIMRLNG LNNFFIYPGQ KLKVSGTASS SNAASNSSRP
160 170 180 190 200
STNSGGGSYY TVQAGDSLSL IASKYGTTYQ KIMSLNGLNN FFIYPGQKLK
210 220 230 240 250
VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF NRRAEIGKGI
260 270 280 290 300
STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND
310 320 330
GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH
Length:334
Mass (Da):35,836
Last modified:March 21, 2006 - v1
Checksum:i4C1E30AD9DE61D36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD20550.1.
RefSeqiYP_493151.1. NC_007793.1.

Genome annotation databases

EnsemblBacteriaiABD20550; ABD20550; SAUSA300_0438.
KEGGisaa:SAUSA300_0438.
PATRICi19590140. VBIStaAur129981_0510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD20550.1.
RefSeqiYP_493151.1. NC_007793.1.

3D structure databases

ProteinModelPortaliQ2FJH7.
SMRiQ2FJH7. Positions 28-201, 228-334.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD20550; ABD20550; SAUSA300_0438.
KEGGisaa:SAUSA300_0438.
PATRICi19590140. VBIStaAur129981_0510.

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiEMNYSAS.
OrthoDBiEOG6GTZPF.

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-438-MONOMER.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiSLE1_STAA3
AccessioniPrimary (citable) accession number: Q2FJH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 21, 2006
Last modified: June 24, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.