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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Binding sitei206ATPUniRule annotation1
Binding sitei294ATP; via carbonyl oxygenUniRule annotation1
Binding sitei325ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi352 – 355ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:SAUSA300_0757
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001939 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096481 – 396Phosphoglycerate kinaseAdd BLAST396

Proteomic databases

PRIDEiQ2FIM0.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2FIM0.
SMRiQ2FIM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227108.
KOiK00927.
OMAiAGHPVGK.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FIM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKIVSDLD LKGKTVLVRA DFNVPLKDGE ITNDNRIVQA LPTIQYIIEQ
60 70 80 90 100
GGKIVLFSHL GKVKEESDKA KLTLRPVAED LSKKLDKEVV FVPETRGEKL
110 120 130 140 150
EAAIKDLKEG DVLLVENTRY EDLDGKKESK NDPELGKYWA SLGDVFVNDA
160 170 180 190 200
FGTAHREHAS NVGISTHLET AAGFLMDKEI KFIGGVVNDP HKPVVAILGG
210 220 230 240 250
AKVSDKINVI KNLVNIADKI IIGGGMAYTF LKAQGKEIGI SLLEEDKIDF
260 270 280 290 300
AKDLLEKHGD KIVLPVDTKV AKEFSNDAKI TVVPSDSIPA DQEGMDIGPN
310 320 330 340 350
TVKLFADELE GAHTVVWNGP MGVFEFSNFA QGTIGVCKAI ANLKDAITII
360 370 380 390
GGGDSAAAAI SLGFENDFTH ISTGGGASLE YLEGKELPGI KAINNK
Length:396
Mass (Da):42,602
Last modified:March 21, 2006 - v1
Checksum:iC8383CFDBC5BF4EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD20896.1.

Genome annotation databases

EnsemblBacteriaiABD20896; ABD20896; SAUSA300_0757.
KEGGisaa:SAUSA300_0757.
PATRICi19590821. VBIStaAur129981_0839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD20896.1.

3D structure databases

ProteinModelPortaliQ2FIM0.
SMRiQ2FIM0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2FIM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD20896; ABD20896; SAUSA300_0757.
KEGGisaa:SAUSA300_0757.
PATRICi19590821. VBIStaAur129981_0839.

Phylogenomic databases

HOGENOMiHOG000227108.
KOiK00927.
OMAiAGHPVGK.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_STAA3
AccessioniPrimary (citable) accession number: Q2FIM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.