Reviewed,
UniProtKB/Swiss-Prot Q2FIE3 (DLTA_STAA3)
Last modified
June 16, 2009.
Version 23.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: D-alanine--poly(phosphoribitol) ligase subunit 1 EC=6.1.1.13 Alternative name(s): D-alanine-activating enzyme Short name=DAE D-alanine-D-alanyl carrier protein ligase Short name=DCL | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 367830 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 485 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp By similarity. |
| Catalytic activity | ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00593 |
| Pathway | Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00593 |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | teichoic acid biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | AMP binding Inferred from electronic annotation. Source: InterPro ATP bindingInferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 485 | 485 | D-alanine--poly(phosphoribitol) ligase subunit 1 HAMAP MF_00593 | PRO_1000025533 | |||
Sequences
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References
| [1] | "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000255 Genomic DNA. Translation: ABD22135.1. | |
| RefSeq | YP_493535.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3913697. |
| GenomeReviews | Gene locus SAUSA300_0835 in contig CP000255_GR. |
| KEGG | saa:SAUSA300_0835. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q2FIE3. |
| OMA | Q2FIE3. CVKSGHA. |
Family and domain databases | |
| HAMAP | MF_00593. [Tree] |
| InterPro | IPR010071. AA_adenyl_domain. IPR000873. AMP-dep_Synth/Lig. IPR010072. D_ala_DACP_lig. [Graphical view] |
| PANTHER | PTHR11968:SF34. D_ala_DACP_lig. 1 hit. |
| Pfam | PF00501. AMP-binding. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01733. AA-adenyl-dom. 1 hit. TIGR01734. D-ala-DACP-lig. 1 hit. |
| PROSITE | PS00455. AMP_BINDING. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DLTA_STAA3 | ||||||||
| Accession | Primary (citable) accession number: Q2FIE3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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