Reviewed, UniProtKB/Swiss-Prot Q2FIE1 (DLTC_STAA3)

Names and origin

Protein names

Recommended name:
    D-alanine--poly(phosphoribitol) ligase subunit 2
    EC=6.1.1.13
Alternative name(s):
    D-alanyl carrier protein
      Short name=DCP

Gene names

Name:	dltC
Ordered Locus Names:	SAUSA300_0837

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA By similarity.
Catalytic activity	ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00565
Pathway	Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00565
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP By similarity.
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation
Ligand	ATP-binding Nucleotide-binding Phosphopantetheine
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activity Inferred from electronic annotation. Source: HAMAP acyl carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 78	78	D-alanine--poly(phosphoribitol) ligase subunit 2 HAMAP MF_00565		PRO_1000024924
Amino acid modifications
	Modified residue	36	1	O-(pantetheine 4'-phosphoryl)serine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q2FIE1-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: C001D1D3D189A584	FASTA	78	9,063
	10 20 30 40 50 60 MEFREQVLNL LAEVAENDIV KENPDVEIFE EGIIDSFQTV GLLLEIQNKL DIEVSIMDFD 70 RDEWATPNKI VEALEELR

References

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000255 Genomic DNA. Translation: ABD20609.1.
RefSeq	YP_493537.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3912974.
GenomeReviews	Gene locus SAUSA300_0837 in contig CP000255_GR.
KEGG	saa:SAUSA300_0837.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FIE1.
OMA	Q2FIE1. EWDTPNK.
Family and domain databases
HAMAP	MF_00565. [Tree]
InterPro	IPR003230. D-ala_carrier. [Graphical view]
ProDom	PD015103. D-ala_carrier. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01688. dltC. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLTC_STAA3

Accession

Primary (citable) accession number: Q2FIE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)