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Q2FH71 (TYRA_STAA3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Prephenate dehydrogenase

Short name=PDH
EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:SAUSA300_1260
OrganismStaphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]
Taxonomic identifier367830 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Prephenate dehydrogenase
PRO_0000282662

Regions

Domain2 – 291290Prephenate/arogenate dehydrogenase
Domain296 – 36368ACT
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q2FH71 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 8F16333DC3B816C6

FASTA36340,395
        10         20         30         40         50         60 
MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE KCLNYSEAIK 

        70         80         90        100        110        120 
KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA MIQQHECNLL KHNIHLVSGH 

       130        140        150        160        170        180 
PMAGSHKSGV LNAKKHLFEN AYYILVYNEP RNEQAANTLK ELLSPTLAKF IVTTAEEHDY 

       190        200        210        220        230        240 
VTSVVSHLPH IVASSLVHVS QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK 

       250        260        270        280        290        300 
TYILEMIRQL KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 

       310        320        330        340        350        360 
IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER GMQALSDFDC 


YIQ 

« Hide

References

[1]"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USA300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000255 Genomic DNA. Translation: ABD20619.1.
RefSeqYP_493957.1. NC_007793.1.

3D structure databases

ProteinModelPortalQ2FH71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING451515.SAUSA300_1260.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD20619; ABD20619; SAUSA300_1260.
GeneID3912984.
KEGGsaa:SAUSA300_1260.
PATRIC19591905. VBIStaAur129981_1381.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHOG000043494.
KOK04517.
OMAHAMAGTH.
OrthoDBEOG6B8XMB.

Enzyme and pathway databases

BioCycSAUR451515:GH3C-1260-MONOMER.
UniPathwayUPA00122; UER00961.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_STAA3
AccessionPrimary (citable) accession number: Q2FH71
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways