Q2FH15 (MSRB_STAA3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	SAUSA300_1316

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000068296
Sites
	Active site	114	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2FH15 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 8B8DD1390D9F80AD	FASTA	142	16,277
	10 20 30 40 50 60 MLKKDKSELT DIEYIVTQEN GTEPPFMNEY WNHFAKGIYV DKISGKPLFT SEEKFHSECG 70 80 90 100 110 120 WPSFSKALDD DEIIELVDKS FGMLRTEVRS EESNSHLGHV FNDGPKESGG LRYCINSAAI 130 140 QFIPYEKLEE LGYGDLISHF DK

References

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USA300.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000255 Genomic DNA. Translation: ABD21574.1.
RefSeq	YP_494013.1. NC_007793.1.
3D structure databases
ProteinModelPortal	Q2FH15.
SMR	Q2FH15. Positions 9-142.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000038719; EBSTAP00000037427; EBSTAG00000038717.
GeneID	3914272.
GenomeReviews	Gene locus SAUSA300_1316 in contig CP000255_GR.
KEGG	saa:SAUSA300_1316.
PATRIC	19592025. VBIStaAur129981_1441.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
GeneTree	EBGT00050000024012.
HOGENOM	HBG715255.
OMA	FTDGPVD.
ProtClustDB	PRK00222.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_STAA3

Accession

Primary (citable) accession number: Q2FH15

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program