ID   THD2_STAA3              Reviewed;         346 AA.
AC   Q2FH01;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Threonine dehydratase catabolic;
DE            EC=4.3.1.19;
DE   AltName: Full=Threonine deaminase;
GN   Name=tdcB; OrderedLocusNames=SAUSA300_1330;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16517273; DOI=10.1016/S0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Acts on both serine and threonine, and properly
CC       considered as a hydroxy amino acid deaminase (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-threonine = 2-oxobutanoate + NH(3).
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-threonine degradation via
CC       propanoate pathway; propanoate from L-threonine: step 1/4.
CC   -!- SIMILARITY: Belongs to the serine/threonine dehydratase family.
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DR   EMBL; CP000255; ABD20948.1; -; Genomic_DNA.
DR   RefSeq; YP_494027.1; -.
DR   GeneID; 3913061; -.
DR   GenomeReviews; CP000255_GR; SAUSA300_1330.
DR   KEGG; saa:SAUSA300_1330; -.
DR   HOGENOM; Q2FH01; -.
DR   OMA; Q2FH01; IRGALNF.
DR   GO; GO:0004794; F:L-threonine ammonia-lyase activity; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   InterPro; IPR001926; PyrdxlP-dep_enz_bsu.
DR   InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR   InterPro; IPR005789; Thr_deHydtase_2.
DR   Pfam; PF00291; PALP; 1.
DR   TIGRFAMs; TIGR01127; ilvA_1Cterm; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Lyase; Pyridoxal phosphate.
FT   CHAIN         1    346       Threonine dehydratase catabolic.
FT                                /FTId=PRO_0000287334.
FT   MOD_RES      64     64       N6-(pyridoxal phosphate)lysine (By
FT                                similarity).
SQ   SEQUENCE   346 AA;  37306 MW;  A69CB839024C9C5F CRC64;
     MTTNTVTLQT AHIVSLGDIE EAKASIKPFI RRTPLIKSMY LSQSITKGNV FLKLENMQFT
     GSFKFRGASN KINHLTDEQK EKGIIAASAG NHAQGVALTA KLLGIDATIV MPETAPQAKQ
     QATKGYGAKV ILKGKNFNET RLYMEELAKE NGMTIVHPYD DKFVMAGQGT IGLEILDDIW
     NVNTVIVPVG GGGLIAGIAT ALKSFNPSIH IIGVQSENVH GMAESFYKRD LTEHRVDSTI
     ADGCDVKVPG EQTYEVVKHL VDEFILVTEE EIEHAMKDLM QRAKIITEGA GALPTAAILS
     GKINNKWLED KNVVALVSGG NVDLTRVSGV IEHGLNIADT SKGVVG
//