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Q2FGI7

- GCSPB_STAA3

UniProt

Q2FGI7 - GCSPB_STAA3

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, SAUSA300_1496
Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-1496-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:SAUSA300_1496
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001939: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_1000045703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi451515.SAUSA300_1496.

Structurei

3D structure databases

ProteinModelPortaliQ2FGI7.
SMRiQ2FGI7. Positions 52-464.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FGI7-1 [UniParc]FASTAAdd to Basket

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MTSKSSPLIF ERSREGRYAY SLPKSDIKTN SVESLLDDKF IRKNKAEFPE    50
VAELDLVRHY TELSNKNFGV DNGFYPLGSC TMKYNPKINE KVARIPGFSE 100
SHPLQDEDQV QGSLEIIYSL QEELKEITGM DEVTLQPAAG AHGEWTALMI 150
FKAYHENNGE GHRDEVIVPD SAHGTNPASA SFAGFKSVTV KSNERGEVDI 200
DDLKRVVNEN TAAIMLTNPN TLGIFEKNIM EIREIVHNAG GLLYYDGANL 250
NAIMDKVRPG DMGFDAVHLN LHKTFTGPHG GGGPGSGPVG VVKELASYLP 300
KPMVIKDGDK FKYDNDIKNS IGRVKPFYGN FGIYLRAYTY IRTMGATGLK 350
EVSEAAVLNA NYIKARLSKH FEIPYKQYCK HEFVLSGVRQ KEFGVRTLDM 400
AKRLLDFGVH PPTIYFPLNV EEGMMIEPTE TESKETLDYF IDTLISIAEE 450
AKNDPDKVLE APHTTVIDRL DEATAARKPI LKFENLKQEK 490
Length:490
Mass (Da):54,782
Last modified:March 21, 2006 - v1
Checksum:i6ECEECB416D35CB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD20628.1.
RefSeqiYP_494191.1. NC_007793.1.

Genome annotation databases

EnsemblBacteriaiABD20628; ABD20628; SAUSA300_1496.
GeneIDi3913110.
KEGGisaa:SAUSA300_1496.
PATRICi19592415. VBIStaAur129981_1636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD20628.1 .
RefSeqi YP_494191.1. NC_007793.1.

3D structure databases

ProteinModelPortali Q2FGI7.
SMRi Q2FGI7. Positions 52-464.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 451515.SAUSA300_1496.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD20628 ; ABD20628 ; SAUSA300_1496 .
GeneIDi 3913110.
KEGGi saa:SAUSA300_1496.
PATRICi 19592415. VBIStaAur129981_1636.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SAUR451515:GH3C-1496-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiGCSPB_STAA3
AccessioniPrimary (citable) accession number: Q2FGI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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