Q2FGC8 (AROE_STAA3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	SAUSA300_1555

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021339
Regions
	Nucleotide binding	124 – 128	5	NADP By similarity
Sites
	Active site	64	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2FGC8 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 700864CB11686B89	FASTA	268	29,879
	10 20 30 40 50 60 MKFAVIGNPI SHSLSPVMHR ANFNSLGLDD TYEALNIPIE DFHLIKEIIS KKELEGFNIT 70 80 90 100 110 120 IPHKERIIPY LDYVDEQAIN AGAVNTVLIK DGKWIGYNTD GIGYVKGLHS VYPDLENAYI 130 140 150 160 170 180 LILGAGGASK GIAYELAKFV KPKLTVANRT MARFESWNLN INQISLADAE KYLAEFDIVI 190 200 210 220 230 240 NTTPAGMAGN NESIINLKHL SPNTLMSDIV YIPYKTPILE EAERKGNHIY NGLDMFVYQG 250 260 AESFKIWTNK DADINSMKTA VLQQLKGE

References

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USA300.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000255 Genomic DNA. Translation: ABD21182.1.
RefSeq	YP_494250.1. NC_007793.1.
3D structure databases
HSSP	HSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
ProteinModelPortal	Q2FGC8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000037006; EBSTAP00000035714; EBSTAG00000037004.
GeneID	3914188.
GenomeReviews	Gene locus SAUSA300_1555 in contig CP000255_GR.
KEGG	saa:SAUSA300_1555.
PATRIC	19592537. VBIStaAur129981_1698.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000025479.
HOGENOM	HBG553408.
OMA	TLFMKKG.
ProtClustDB	CLSK885454.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_STAA3

Accession

Primary (citable) accession number: Q2FGC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program