ID   MENE_STAA3              Reviewed;         492 AA.
AC   Q2FFU9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=2-succinylbenzoate--CoA ligase;
DE            EC=6.2.1.26;
DE   AltName: Full=OSB-CoA synthetase;
DE   AltName: Full=o-succinylbenzoyl-CoA synthetase;
GN   Name=menE; OrderedLocusNames=SAUSA300_1737;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16517273; DOI=10.1016/S0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-
CC       CoA (OSB-CoA).
CC   -!- CATALYTIC ACTIVITY: ATP + 2-succinylbenzoate + CoA = AMP +
CC       diphosphate + 2-succinylbenzoyl-CoA.
CC   -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC       menaquinone from chorismate: step 5/8.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
CC       family. MenE type 1 subfamily.
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DR   EMBL; CP000255; ABD22067.1; -; Genomic_DNA.
DR   RefSeq; YP_494429.1; -.
DR   GeneID; 3913648; -.
DR   GenomeReviews; CP000255_GR; SAUSA300_1737.
DR   KEGG; saa:SAUSA300_1737; -.
DR   HOGENOM; Q2FFU9; -.
DR   OMA; Q2FFU9; DSPSNIL.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008756; F:o-succinylbenzoate-CoA ligase activity; IEA:HAMAP.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00731; -; 1.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR010192; MenE.
DR   Pfam; PF00501; AMP-binding; 1.
DR   TIGRFAMs; TIGR01923; menE; 1.
DR   PROSITE; PS00455; AMP_BINDING; FALSE_NEG.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Ligase; Menaquinone biosynthesis;
KW   Nucleotide-binding.
FT   CHAIN         1    492       2-succinylbenzoate--CoA ligase.
FT                                /FTId=PRO_1000045966.
SQ   SEQUENCE   492 AA;  55415 MW;  36D409105A4F7930 CRC64;
     MDFWLYKQAQ QNGHHIAITD GQESYTYQNL YCEASLLAKR LKAYQQSRVG LYIDNSIQSI
     ILIHACWLAN IEIAMINTRL TPNEMTNQMK SIDVQLIFCT LPLELRGFQI VSLDDIEFAG
     RDITTNSLLD NTMGIQYETS NETVVPKESP SNILNTSFNL DDIASIMFTS GTTGPQKAVP
     QTFRNHYASA IGCKESLGFD RDTNWLSVLP IYHISGLSVL LRAVIEGFTV RIVDKFNAEQ
     ILTMIKNERI THISLVPQTL NWLMQQGLHE PYNLQKILLG GAKLSATMIE TALQYNLPIY
     NSFGMTETCS QFLTATPEML HARPDTVGMP SANVDVKIKN PNKEGHGELM IKGANVMNVY
     LYPTDLTGTF ENGYFNTGDI AEIDHEGYVM IYDRRKDLII SGGENIYPYQ IETVAKQFPG
     ISDAVCVGHP DDTWGQVPKL YFVSESDISK AQLIAYLSQH LAKYKVPKHF EKVDTLPYTS
     TGKLQRNKLY RG
//