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Q2FFU9 (MENE_STAA3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-succinylbenzoate--CoA ligase
EC=6.2.1.26
Alternative name(s):
OSB-CoA synthetase
o-succinylbenzoyl-CoA synthetase
Gene names
Name:menE
Ordered Locus Names:SAUSA300_1737
OrganismStaphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]
Taxonomic identifier367830 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). HAMAP MF_00731

Catalytic activity

ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA. HAMAP MF_00731

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 5/8. HAMAP MF_00731

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

o-succinylbenzoate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4924922-succinylbenzoate--CoA ligase HAMAP MF_00731
PRO_1000045966

Sequences

Sequence LengthMass (Da)Tools
Q2FFU9 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 36D409105A4F7930

FASTA49255,415
        10         20         30         40         50         60 
MDFWLYKQAQ QNGHHIAITD GQESYTYQNL YCEASLLAKR LKAYQQSRVG LYIDNSIQSI 

        70         80         90        100        110        120 
ILIHACWLAN IEIAMINTRL TPNEMTNQMK SIDVQLIFCT LPLELRGFQI VSLDDIEFAG 

       130        140        150        160        170        180 
RDITTNSLLD NTMGIQYETS NETVVPKESP SNILNTSFNL DDIASIMFTS GTTGPQKAVP 

       190        200        210        220        230        240 
QTFRNHYASA IGCKESLGFD RDTNWLSVLP IYHISGLSVL LRAVIEGFTV RIVDKFNAEQ 

       250        260        270        280        290        300 
ILTMIKNERI THISLVPQTL NWLMQQGLHE PYNLQKILLG GAKLSATMIE TALQYNLPIY 

       310        320        330        340        350        360 
NSFGMTETCS QFLTATPEML HARPDTVGMP SANVDVKIKN PNKEGHGELM IKGANVMNVY 

       370        380        390        400        410        420 
LYPTDLTGTF ENGYFNTGDI AEIDHEGYVM IYDRRKDLII SGGENIYPYQ IETVAKQFPG 

       430        440        450        460        470        480 
ISDAVCVGHP DDTWGQVPKL YFVSESDISK AQLIAYLSQH LAKYKVPKHF EKVDTLPYTS 

       490 
TGKLQRNKLY RG

« Hide

References

[1]"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USA300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000255 Genomic DNA. Translation: ABD22067.1.
RefSeqYP_494429.1. NC_007793.1.

3D structure databases

ProteinModelPortalQ2FFU9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000038686; EBSTAP00000037394; EBSTAG00000038684.
GeneID3913648.
GenomeReviewsGene locus SAUSA300_1737 in contig CP000255_GR.
KEGGsaa:SAUSA300_1737.
PATRIC19592927. VBIStaAur129981_1893.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0318.
GeneTreeEBGT00050000024490.
HOGENOMHBG547964.
OMAERIASIM.
ProtClustDBCLSK885565.

Family and domain databases

HAMAPMF_00731. MenE.
[Tree]
InterProIPR000873. AMP-dep_Synth/Lig.
IPR010192. MenE.
IPR023015. SB_CoA_ligase_firmicutes.
[Graphical view]
KOK01911.
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsTIGR01923. MenE. 1 hit.
PROSITEPS00455. AMP_BINDING. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMENE_STAA3
AccessionPrimary (citable) accession number: Q2FFU9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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