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Protein

Sodium/proline symporter

Gene

putP

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sodium-dependent uptake of extracellular L-proline. Since most S.aureus strains are L-proline auxotrophs, this transporter may aid the bacterial persistence during an infection of tissues with low proline concentrations.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/proline symporter
Alternative name(s):
Proline permease
Gene namesi
Name:putP
Ordered Locus Names:SAUSA300_1883
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001939 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003641051 – 512Sodium/proline symporterAdd BLAST512

Proteomic databases

PRIDEiQ2FFJ3

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000282935
KOiK11928
OMAiCWTDLIQ

Family and domain databases

CDDicd11475 SLC5sbd_PutP, 1 hit
Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR011851 Na/Pro_symporter
IPR001734 Na/solute_symporter
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR02121 Na_Pro_sym, 1 hit
TIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FFJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTMGTALSQ QVDANWQTYI MIAVYFLILI VIGFYGYKQA TGNLSEYMLG
60 70 80 90 100
GRSIGPYITA LSAGASDMSG WMIMGLPGSV YSTGLSAMWI TIGLTLGAYI
110 120 130 140 150
NYFVVAPRLR VYTELAGDAI TLPDFFKNRL NDKNNVLKII SGLIIVVFFT
160 170 180 190 200
LYTHSGFVSG GKLFESAFGL DYHFGLILVA FIVIFYTFFG GYLAVSITDF
210 220 230 240 250
FQGVIMLIAM VMVPIVAMMN LNGWGTFHDV AAMKPTNLNL FKGLSFIGII
260 270 280 290 300
SLFSWGLGYF GQPHIIIRFM SIKSHKMLPK ARRLGISWMA VGLLGAVAVG
310 320 330 340 350
LTGIAFVPAY HIKLEDPETL FIVMSQVLFH PLVGGFLLAA ILAAIMSTIS
360 370 380 390 400
SQLLVTSSSL TEDFYKLIRG EEKAKTHQKE FVMIGRLSVL VVAIVAIAIA
410 420 430 440 450
WNPNDTILNL VGNAWAGFGA SFSPLVLFAL YWKGLTRAGA VSGMVSGALV
460 470 480 490 500
VIVWIAWIKP LAHINEIFGL YEIIPGFIVS VIVTYVVSKL TKKPGAFVET
510
DLNKVRDIVR EK
Length:512
Mass (Da):55,990
Last modified:March 21, 2006 - v1
Checksum:i70B93C52311F1AAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA Translation: ABD20504.1

Genome annotation databases

EnsemblBacteriaiABD20504; ABD20504; SAUSA300_1883
KEGGisaa:SAUSA300_1883

Similar proteinsi

Entry informationi

Entry nameiPUTP_STAA3
AccessioniPrimary (citable) accession number: Q2FFJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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