Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2FF27 (Q2FF27_STAA3) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111

EC=2.5.1.7 HAMAP-Rule MF_00111
Alternative name(s):
Enoylpyruvate transferase HAMAP-Rule MF_00111
UDP-N-acetylglucosamine enolpyruvyl transferase HAMAP-Rule MF_00111
Gene names
Name:murA HAMAP-Rule MF_00111 EMBL ABD21703.1
Ordered Locus Names:SAUSA300_2055 EMBL ABD21703.1
OrganismStaphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]
Taxonomic identifier367830 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. SAAS SAAS005750 HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005750 HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity SAAS SAAS005750 HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily. HAMAP-Rule MF_00111

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1191Proton donor By similarity HAMAP-Rule MF_00111

Amino acid modifications

Modified residue11912-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity HAMAP-Rule MF_00111

Sequences

Sequence LengthMass (Da)Tools
Q2FF27 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 2C5AC71CA2A761D9

FASTA42145,054
        10         20         30         40         50         60 
MDKIVIKGGN KLTGEVKVEG AKNAVLPILT ASLLASDKPS KLVNVPALSD VETINNVLTT 

        70         80         90        100        110        120 
LNADVTYKKD ENAVVVDATK TLNEEAPYEY VSKMRASILV MGPLLARLGH AIVALPGGCA 

       130        140        150        160        170        180 
IGSRPIEQHI KGFEALGAEI HLENGNIYAN AKDGLKGTSI HLDFPSVGAT QNIIMAASLA 

       190        200        210        220        230        240 
KGKTLIENAA KEPEIVDLAN YINEMGGRIT GAGTDTITIN GVESLHGVEH AIIPDRIEAG 

       250        260        270        280        290        300 
TLLIAGAITR GDIFVRDAIK EHMASLVYKL EEMGVELDYQ EDGIRVRAEG ELQPVDIKTL 

       310        320        330        340        350        360 
PHPGFPTDMQ SQMMALLLTA NGHKVVTETV FENRFMHVAE FKRMNANINV EGRSAKLEGK 

       370        380        390        400        410        420 
SQLQGAQVKA TDLRAAAALI LAGLVADGKT SVTELTHLDR GYVDLHGKLK QLGADIERIN 


D 

« Hide

References

[1]"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USA300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000255 Genomic DNA. Translation: ABD21703.1.
RefSeqYP_494701.1. NC_007793.1.

3D structure databases

ProteinModelPortalQ2FF27.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING451515.SAUSA300_2055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD21703; ABD21703; SAUSA300_2055.
GeneID3912790.
KEGGsaa:SAUSA300_2055.
PATRIC19593617. VBIStaAur129981_2194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000075602.
KOK00790.
OMAGYEHIED.
OrthoDBEOG68M4GK.
ProtClustDBPRK09369.

Enzyme and pathway databases

BioCycSAUR451515:GH3C-2055-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2FF27_STAA3
AccessionPrimary (citable) accession number: Q2FF27
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)