Q2FEU0 (LACD_STAA3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tagatose 1,6-diphosphate aldolase
EC=4.1.2.40

Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase
Tagatose-bisphosphate aldolase

Gene names

Name:	lacD
Ordered Locus Names:	SAUSA300_2152

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_00734
Pathway	Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2. HAMAP MF_00734
Sequence similarities	Belongs to the aldolase lacD family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: InterPro
Molecular function	tagatose-6-phosphate kinase activity Inferred from electronic annotation. Source: InterPro tagatose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Tagatose 1,6-diphosphate aldolase HAMAP MF_00734		PRO_1000045977

Sequences

	Sequence		Length	Mass (Da)
	Q2FEU0 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 20766B1B841372C1	FASTA	326	36,595
	10 20 30 40 50 60 MSKSNQKIAS IEQLSNNEGI ISALAFDQRG ALKRMMAKHQ TEEPTVAQIE QLKVLVAEEL 70 80 90 100 110 120 TQYASSILLD PEYGLPASDA RNKDCGLLLA YEKTGYDVNA KGRLPDCLVE WSAKRLKEQG 130 140 150 160 170 180 ANAVKFLLYY DVDDAEEINI QKKAYIERIG SECVAEDIPF FLEVLTYDDN IPDNGSVEFA 190 200 210 220 230 240 KVKPRKVNEA MKLFSEPRFN VDVLKVEVPV NMKYVEGFAE GEVVYTKEEA AQHFKDQDAA 250 260 270 280 290 300 THLPYIYLSA GVSAELFQET LKFAHEAGAK FNGVLCGRAT WSGAVQVYIE QGEDAAREWL 310 320 RTTGFKNIDD LNKVLKDTAT SWKQRK

References

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USA300.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000255 Genomic DNA. Translation: ABD20452.1.
RefSeq	YP_494788.1. NC_007793.1.
3D structure databases
ProteinModelPortal	Q2FEU0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000037550; EBSTAP00000036258; EBSTAG00000037548.
GeneID	3913851.
GenomeReviews	Gene locus SAUSA300_2152 in contig CP000255_GR.
KEGG	saa:SAUSA300_2152.
PATRIC	19593824. VBIStaAur129981_2288.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3684.
GeneTree	EBGT00050000025283.
HOGENOM	HBG290828.
OMA	RVGSECV.
ProtClustDB	PRK12399.
Family and domain databases
HAMAP	MF_00734. LacD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR002915. DeoC/AroFGH_arch. IPR005927. LacD. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01635.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01232. LacD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACD_STAA3

Accession

Primary (citable) accession number: Q2FEU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program