Reviewed, UniProtKB/Swiss-Prot Q2FET7 (LACA_STAA3)

Names and origin

Protein names

Recommended name:
    Galactose-6-phosphate isomerase subunit lacA
    EC=5.3.1.26

Gene names

Name:	lacA
Ordered Locus Names:	SAUSA300_2155

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP MF_01555
Pathway	Carbohydrate metabolism; galactose degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP MF_01555
Subunit structure	Heteromultimeric protein consisting of lacA and lacB By similarity.
Sequence similarities	Belongs to the lacAB/rpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: HAMAP
Molecular function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Galactose-6-phosphate isomerase subunit lacA HAMAP MF_01555		PRO_1000068922

Sequences

	Sequence		Length	Mass (Da)
	Q2FET7-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: A52C4A7DBF30BE19	FASTA	142	15,395
	10 20 30 40 50 60 MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD VQSQEGNLGI 70 80 90 100 110 120 VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR MITMGSEIVG DTLAKNVVKG 130 140 FVEGKYDGGR HQIRVDMLNK MC

References

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000255 Genomic DNA. Translation: ABD21643.1.
RefSeq	YP_494791.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3914500.
GenomeReviews	Gene locus SAUSA300_2155 in contig CP000255_GR.
KEGG	saa:SAUSA300_2155.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FET7.
OMA	Q2FET7. SAMASNK.
Family and domain databases
HAMAP	MF_01555. [Tree]
InterPro	IPR004783. LacA. IPR003500. Rib/Gal_isomrase. [Graphical view]
Gene3D	G3DSA:3.40.1400.10. Rib/Gal_isomrase. 1 hit.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
TIGRFAMs	TIGR01118. lacA. 1 hit. TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACA_STAA3

Accession

Primary (citable) accession number: Q2FET7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)