ID   BIOW_STAA3              Reviewed;         230 AA.
AC   Q2FE74;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=6-carboxyhexanoate--CoA ligase;
DE            EC=6.2.1.14;
DE   AltName: Full=Pimeloyl-CoA synthase;
GN   Name=bioW; OrderedLocusNames=SAUSA300_2369;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16517273; DOI=10.1016/S0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Transforms pimelate into pimeloyl-CoA (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + 6-carboxyhexanoate + CoA = AMP +
CC       diphosphate + 6-carboxyhexanoyl-CoA.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; 6-
CC       carboxyhexanoyl-CoA from 6-carboxyhexanoate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the bioW family.
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DR   EMBL; CP000255; ABD22590.1; -; Genomic_DNA.
DR   RefSeq; YP_495004.1; -.
DR   GeneID; 3913096; -.
DR   GenomeReviews; CP000255_GR; SAUSA300_2369.
DR   KEGG; saa:SAUSA300_2369; -.
DR   HOGENOM; Q2FE74; -.
DR   OMA; Q2FE74; TVDAIAI.
DR   GO; GO:0042410; F:6-carboxyhexanoate-CoA ligase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00668; -; 1.
DR   InterPro; IPR005499; BioW.
DR   Pfam; PF03744; BioW; 1.
DR   ProDom; PD017229; BioW; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    230       6-carboxyhexanoate--CoA ligase.
FT                                /FTId=PRO_1000044696.
SQ   SEQUENCE   230 AA;  26092 MW;  345AB71E281355DE CRC64;
     MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN IKIQKIMEPI
     QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE TVYTGAIILS AISGKRLDSF
     GQRGIRATHF SFEDINNKGD LNERVTDALA IASCINAHPY VKGELCVSDD LTYTTGYFAA
     AKIGYHRLFD IKPVNTRYGG RIIFVDDCID LNHYISFLES TPKQVVYETV
//