Reviewed, UniProtKB/Swiss-Prot Q2FE74 (BIOW_STAA3)

Names and origin

Protein names

Recommended name:
    6-carboxyhexanoate--CoA ligase
    EC=6.2.1.14
Alternative name(s):
    Pimeloyl-CoA synthase

Gene names

Name:	bioW
Ordered Locus Names:	SAUSA300_2369

Organism

Staphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]

Taxonomic identifier

367830 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transforms pimelate into pimeloyl-CoA By similarity.
Catalytic activity	ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA. HAMAP MF_00668
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; 6-carboxyhexanoyl-CoA from 6-carboxyhexanoate: step 1/1. HAMAP MF_00668
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the bioW family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	6-carboxyhexanoate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	6-carboxyhexanoate--CoA ligase HAMAP MF_00668		PRO_1000044696

Sequences

	Sequence		Length	Mass (Da)
	Q2FE74-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 345AB71E281355DE	FASTA	230	26,092
	10 20 30 40 50 60 MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN IKIQKIMEPI 70 80 90 100 110 120 QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE TVYTGAIILS AISGKRLDSF 130 140 150 160 170 180 GQRGIRATHF SFEDINNKGD LNERVTDALA IASCINAHPY VKGELCVSDD LTYTTGYFAA 190 200 210 220 230 AKIGYHRLFD IKPVNTRYGG RIIFVDDCID LNHYISFLES TPKQVVYETV

References

[1]

"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus." Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F. Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000255 Genomic DNA. Translation: ABD22590.1.
RefSeq	YP_495004.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3913096.
GenomeReviews	Gene locus SAUSA300_2369 in contig CP000255_GR.
KEGG	saa:SAUSA300_2369.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FE74.
OMA	Q2FE74. TVDAIAI.
Family and domain databases
HAMAP	MF_00668. [Tree]
InterPro	IPR005499. BioW. [Graphical view]
Pfam	PF03744. BioW. 1 hit. [Graphical view]
ProDom	PD017229. BioW. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

BIOW_STAA3

Accession

Primary (citable) accession number: Q2FE74

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)