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Q2FE03 (FNBA_STAA3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fibronectin-binding protein A
Gene names
Name:fnbA
Ordered Locus Names:SAUSA300_2441
OrganismStaphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]
Taxonomic identifier367830 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length1018 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin. This confers to S.aureus the ability to invade endothelial cells. Promotes adherence to and aggregation of activated platelets By similarity.

Subcellular location

Secreted › cell wall; Peptidoglycan-anchor Potential.

Ontologies

Keywords
   Biological processCell adhesion
Virulence
   Cellular componentCell wall
Secreted
   DomainRepeat
Signal
   PTMPeptidoglycan-anchor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

pathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 Potential
Chain37 – 985949Fibronectin-binding protein A
PRO_0000313874
Propeptide986 – 101833Removed by sortase Potential
PRO_0000313875

Regions

Repeat545 – 57430B-1
Repeat575 – 60430B-2
Repeat745 – 78238D-1
Repeat783 – 82038D-2
Repeat821 – 85939D-3
Repeat860 – 87819D-4; truncated
Repeat879 – 89214WR 1
Repeat893 – 90614WR 2
Repeat907 – 92014WR 3
Repeat921 – 93414WR 4
Repeat935 – 94814WR 5
Region37 – 511475Ligand-binding A region
Region194 – 511318Fibrinogen/elastin/tropoelastin-binding By similarity
Region512 – 872361Fibronectin-binding By similarity
Region545 – 604602 X approximate tandem repeats
Region745 – 8781344 X approximate tandem repeats
Region879 – 948705 X tandem repeats, Pro-rich (WR)
Motif982 – 9865LPXTG sorting signal Potential

Amino acid modifications

Modified residue9851Pentaglycyl murein peptidoglycan amidated threonine Potential

Sequences

Sequence LengthMass (Da)Tools
Q2FE03 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 9B215B90035EEA6E

FASTA1,018111,709
        10         20         30         40         50         60 
MKNNLRYGIR KHKLGAASVF LGTMIVVGMG QDKEAAASEQ KTTTVEENGN SATDNKTSET 

        70         80         90        100        110        120 
QTTATNVNHI EETQSYNATV TEQPSNATQV TTEEAPKAVQ APQTAQPANI ETVKEEVVKE 

       130        140        150        160        170        180 
EAKPQVKETT QSQDNSGDQR QVDLTPKKAT QNQVAETQVE VAQPRTASES KPRVTRSADV 

       190        200        210        220        230        240 
AEAKEASNAK VETGTDVTSK VTVEIGSIEG HNNTNKVEPH AGQRAVLKYK LKFENGLHQG 

       250        260        270        280        290        300 
DYFDFTLSNN VNTHGVSTAR KVPEIKNGSV VMATGEVLEG GKIRYTFTND IEDKVDVTAE 

       310        320        330        340        350        360 
LEINLFIDPK TVQTNGNQTI TSTLNEEQTS KELDVKYKDG IGNYYANLNG SIETFNKANN 

       370        380        390        400        410        420 
RFSHVAFIKP NNGKTTSVTV TGTLMKGSNQ NGNQPKVRIF EYLGNNEDIA KSVYANTTDT 

       430        440        450        460        470        480 
SKFKEVTSNM SGNLNLQNNG SYSLNIENLD KTYVVHYDGE YLNGTDEVDF RTQMVGHPEQ 

       490        500        510        520        530        540 
LYKYYYDRGY TLTWDNGLVL YSNKANGNGK NGPIIQNNKF EYKEDTIKET LTGQYDKNLV 

       550        560        570        580        590        600 
TTVEEEYDSS TLDIDYHTAI DGGGGYVDGY IETIEETDSS AIDIDYHTAV DSEAGHVGGY 

       610        620        630        640        650        660 
TESSEESNPI DFEESTHENS KHHADVVEYE EDTNPGGGQV TTESNLVEFD EESTKGIVTG 

       670        680        690        700        710        720 
AVSDHTTVED TKEYTTESNL IELVDELPEE HGQAQGPVEE ITENNHHISH SGLGTENGHG 

       730        740        750        760        770        780 
NYDVIEEIEE NSHVDIKSEL GYEGGQNSGN QSFEEDTEED KPKYEQGGNI VDIDFDSVPQ 

       790        800        810        820        830        840 
IHGQNKGNQS FEEDTEKDKP KYEHGGNIID IDFDSVPHIH GFNKHTEIIE EDTNKDKPSY 

       850        860        870        880        890        900 
QFGGHNSVDF EEDTLPKVSG QNEGQQTIEE DTTPPIVPPT PPTPEVPSEP ETPTPPTPEV 

       910        920        930        940        950        960 
PSEPETPTPP TPEVPSEPET PTPPTPEVPA EPGKPVPPAK EEPKKPSKPV EQGKVVTPVI 

       970        980        990       1000       1010 
EINEKVKAVA PTKKPQSKKS ELPETGGEES TNKGMLFGGL FSILGLALLR RNKKNHKA

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References

[1]"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USA300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000255 Genomic DNA. Translation: ABD21634.1.
RefSeqYP_495075.1. NC_007793.1.

3D structure databases

ProteinModelPortalQ2FE03.
ModBaseSearch...

Protein-protein interaction databases

STRING451515.SAUSA300_2441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD21634; ABD21634; SAUSA300_2441.
GeneID3913735.
KEGGsaa:SAUSA300_2441.
PATRIC19594471. VBIStaAur129981_2611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000280272.
KOK13732.
OMADNKVSET.
ProtClustDBCLSK886024.

Enzyme and pathway databases

BioCycSAUR451515:GH3C-2441-MONOMER.

Family and domain databases

Gene3D2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR004237. Fibron_repeat-bd.
IPR005877. Gpos_YSIRK.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG-motif_cell_wall_anchor.
[Graphical view]
PfamPF02986. Fn_bind. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMSSF49401. Adhes_bact. 2 hits.
TIGRFAMsTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNBA_STAA3
AccessionPrimary (citable) accession number: Q2FE03
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info