Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibronectin-binding protein A

Gene

fnbA

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin. This confers to S.aureus the ability to invade endothelial cells. Promotes adherence to and aggregation of activated platelets (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin-binding protein A
Gene namesi
Name:fnbA
Ordered Locus Names:SAUSA300_2441
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001939 Componenti: Chromosome

Subcellular locationi

  • Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000031387437 – 985Fibronectin-binding protein AAdd BLAST949
PropeptideiPRO_0000313875986 – 1018Removed by sortasePROSITE-ProRule annotationAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei985Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRIDEiQ2FE03.

Structurei

3D structure databases

ProteinModelPortaliQ2FE03.
SMRiQ2FE03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati545 – 574B-1Add BLAST30
Repeati575 – 604B-2Add BLAST30
Repeati745 – 782D-1Add BLAST38
Repeati783 – 820D-2Add BLAST38
Repeati821 – 859D-3Add BLAST39
Repeati860 – 878D-4; truncatedAdd BLAST19
Repeati879 – 892WR 1Add BLAST14
Repeati893 – 906WR 2Add BLAST14
Repeati907 – 920WR 3Add BLAST14
Repeati921 – 934WR 4Add BLAST14
Repeati935 – 948WR 5Add BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 511Ligand-binding A regionAdd BLAST475
Regioni194 – 511Fibrinogen/elastin/tropoelastin-bindingBy similarityAdd BLAST318
Regioni512 – 872Fibronectin-bindingBy similarityAdd BLAST361
Regioni545 – 6042 X approximate tandem repeatsAdd BLAST60
Regioni745 – 8784 X approximate tandem repeatsAdd BLAST134
Regioni879 – 9485 X tandem repeats, Pro-rich (WR)Add BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi982 – 986LPXTG sorting signalPROSITE-ProRule annotation5

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000280272.
KOiK13732.
OMAiEVNFRTQ.

Family and domain databases

Gene3Di2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProiIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR004237. Fibron_repeat-bd.
IPR019948. Gram-positive_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF02986. Fn_bind. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FE03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNNLRYGIR KHKLGAASVF LGTMIVVGMG QDKEAAASEQ KTTTVEENGN
60 70 80 90 100
SATDNKTSET QTTATNVNHI EETQSYNATV TEQPSNATQV TTEEAPKAVQ
110 120 130 140 150
APQTAQPANI ETVKEEVVKE EAKPQVKETT QSQDNSGDQR QVDLTPKKAT
160 170 180 190 200
QNQVAETQVE VAQPRTASES KPRVTRSADV AEAKEASNAK VETGTDVTSK
210 220 230 240 250
VTVEIGSIEG HNNTNKVEPH AGQRAVLKYK LKFENGLHQG DYFDFTLSNN
260 270 280 290 300
VNTHGVSTAR KVPEIKNGSV VMATGEVLEG GKIRYTFTND IEDKVDVTAE
310 320 330 340 350
LEINLFIDPK TVQTNGNQTI TSTLNEEQTS KELDVKYKDG IGNYYANLNG
360 370 380 390 400
SIETFNKANN RFSHVAFIKP NNGKTTSVTV TGTLMKGSNQ NGNQPKVRIF
410 420 430 440 450
EYLGNNEDIA KSVYANTTDT SKFKEVTSNM SGNLNLQNNG SYSLNIENLD
460 470 480 490 500
KTYVVHYDGE YLNGTDEVDF RTQMVGHPEQ LYKYYYDRGY TLTWDNGLVL
510 520 530 540 550
YSNKANGNGK NGPIIQNNKF EYKEDTIKET LTGQYDKNLV TTVEEEYDSS
560 570 580 590 600
TLDIDYHTAI DGGGGYVDGY IETIEETDSS AIDIDYHTAV DSEAGHVGGY
610 620 630 640 650
TESSEESNPI DFEESTHENS KHHADVVEYE EDTNPGGGQV TTESNLVEFD
660 670 680 690 700
EESTKGIVTG AVSDHTTVED TKEYTTESNL IELVDELPEE HGQAQGPVEE
710 720 730 740 750
ITENNHHISH SGLGTENGHG NYDVIEEIEE NSHVDIKSEL GYEGGQNSGN
760 770 780 790 800
QSFEEDTEED KPKYEQGGNI VDIDFDSVPQ IHGQNKGNQS FEEDTEKDKP
810 820 830 840 850
KYEHGGNIID IDFDSVPHIH GFNKHTEIIE EDTNKDKPSY QFGGHNSVDF
860 870 880 890 900
EEDTLPKVSG QNEGQQTIEE DTTPPIVPPT PPTPEVPSEP ETPTPPTPEV
910 920 930 940 950
PSEPETPTPP TPEVPSEPET PTPPTPEVPA EPGKPVPPAK EEPKKPSKPV
960 970 980 990 1000
EQGKVVTPVI EINEKVKAVA PTKKPQSKKS ELPETGGEES TNKGMLFGGL
1010
FSILGLALLR RNKKNHKA
Length:1,018
Mass (Da):111,709
Last modified:March 21, 2006 - v1
Checksum:i9B215B90035EEA6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21634.1.

Genome annotation databases

EnsemblBacteriaiABD21634; ABD21634; SAUSA300_2441.
KEGGisaa:SAUSA300_2441.
PATRICi19594471. VBIStaAur129981_2611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21634.1.

3D structure databases

ProteinModelPortaliQ2FE03.
SMRiQ2FE03.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2FE03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD21634; ABD21634; SAUSA300_2441.
KEGGisaa:SAUSA300_2441.
PATRICi19594471. VBIStaAur129981_2611.

Phylogenomic databases

HOGENOMiHOG000280272.
KOiK13732.
OMAiEVNFRTQ.

Miscellaneous databases

PROiQ2FE03.

Family and domain databases

Gene3Di2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProiIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR004237. Fibron_repeat-bd.
IPR019948. Gram-positive_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF02986. Fn_bind. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFNBA_STAA3
AccessioniPrimary (citable) accession number: Q2FE03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.