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Q2FE03

- FNBA_STAA3

UniProt

Q2FE03 - FNBA_STAA3

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Protein

Fibronectin-binding protein A

Gene
fnbA, SAUSA300_2441
Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin. This confers to S.aureus the ability to invade endothelial cells. Promotes adherence to and aggregation of activated platelets By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Virulence

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-2441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin-binding protein A
Gene namesi
Name:fnbA
Ordered Locus Names:SAUSA300_2441
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001939: Chromosome

Subcellular locationi

Secretedcell wall; Peptidoglycan-anchor Reviewed prediction

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636 Reviewed predictionAdd
BLAST
Chaini37 – 985949Fibronectin-binding protein APRO_0000313874Add
BLAST
Propeptidei986 – 101833Removed by sortase Reviewed predictionPRO_0000313875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei985 – 9851Pentaglycyl murein peptidoglycan amidated threonine Reviewed prediction

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi451515.SAUSA300_2441.

Structurei

3D structure databases

ProteinModelPortaliQ2FE03.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati545 – 57430B-1Add
BLAST
Repeati575 – 60430B-2Add
BLAST
Repeati745 – 78238D-1Add
BLAST
Repeati783 – 82038D-2Add
BLAST
Repeati821 – 85939D-3Add
BLAST
Repeati860 – 87819D-4; truncatedAdd
BLAST
Repeati879 – 89214WR 1Add
BLAST
Repeati893 – 90614WR 2Add
BLAST
Repeati907 – 92014WR 3Add
BLAST
Repeati921 – 93414WR 4Add
BLAST
Repeati935 – 94814WR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 511475Ligand-binding A regionAdd
BLAST
Regioni194 – 511318Fibrinogen/elastin/tropoelastin-binding By similarityAdd
BLAST
Regioni512 – 872361Fibronectin-binding By similarityAdd
BLAST
Regioni545 – 604602 X approximate tandem repeatsAdd
BLAST
Regioni745 – 8781344 X approximate tandem repeatsAdd
BLAST
Regioni879 – 948705 X tandem repeats, Pro-rich (WR)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi982 – 9865LPXTG sorting signal Reviewed prediction

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000280272.
KOiK13732.
OMAiNKFTHVA.
OrthoDBiEOG69D37T.

Family and domain databases

Gene3Di2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProiIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR004237. Fibron_repeat-bd.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF02986. Fn_bind. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FE03-1 [UniParc]FASTAAdd to Basket

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MKNNLRYGIR KHKLGAASVF LGTMIVVGMG QDKEAAASEQ KTTTVEENGN     50
SATDNKTSET QTTATNVNHI EETQSYNATV TEQPSNATQV TTEEAPKAVQ 100
APQTAQPANI ETVKEEVVKE EAKPQVKETT QSQDNSGDQR QVDLTPKKAT 150
QNQVAETQVE VAQPRTASES KPRVTRSADV AEAKEASNAK VETGTDVTSK 200
VTVEIGSIEG HNNTNKVEPH AGQRAVLKYK LKFENGLHQG DYFDFTLSNN 250
VNTHGVSTAR KVPEIKNGSV VMATGEVLEG GKIRYTFTND IEDKVDVTAE 300
LEINLFIDPK TVQTNGNQTI TSTLNEEQTS KELDVKYKDG IGNYYANLNG 350
SIETFNKANN RFSHVAFIKP NNGKTTSVTV TGTLMKGSNQ NGNQPKVRIF 400
EYLGNNEDIA KSVYANTTDT SKFKEVTSNM SGNLNLQNNG SYSLNIENLD 450
KTYVVHYDGE YLNGTDEVDF RTQMVGHPEQ LYKYYYDRGY TLTWDNGLVL 500
YSNKANGNGK NGPIIQNNKF EYKEDTIKET LTGQYDKNLV TTVEEEYDSS 550
TLDIDYHTAI DGGGGYVDGY IETIEETDSS AIDIDYHTAV DSEAGHVGGY 600
TESSEESNPI DFEESTHENS KHHADVVEYE EDTNPGGGQV TTESNLVEFD 650
EESTKGIVTG AVSDHTTVED TKEYTTESNL IELVDELPEE HGQAQGPVEE 700
ITENNHHISH SGLGTENGHG NYDVIEEIEE NSHVDIKSEL GYEGGQNSGN 750
QSFEEDTEED KPKYEQGGNI VDIDFDSVPQ IHGQNKGNQS FEEDTEKDKP 800
KYEHGGNIID IDFDSVPHIH GFNKHTEIIE EDTNKDKPSY QFGGHNSVDF 850
EEDTLPKVSG QNEGQQTIEE DTTPPIVPPT PPTPEVPSEP ETPTPPTPEV 900
PSEPETPTPP TPEVPSEPET PTPPTPEVPA EPGKPVPPAK EEPKKPSKPV 950
EQGKVVTPVI EINEKVKAVA PTKKPQSKKS ELPETGGEES TNKGMLFGGL 1000
FSILGLALLR RNKKNHKA 1018
Length:1,018
Mass (Da):111,709
Last modified:March 21, 2006 - v1
Checksum:i9B215B90035EEA6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD21634.1.
RefSeqiYP_495075.1. NC_007793.1.

Genome annotation databases

EnsemblBacteriaiABD21634; ABD21634; SAUSA300_2441.
GeneIDi3913735.
KEGGisaa:SAUSA300_2441.
PATRICi19594471. VBIStaAur129981_2611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD21634.1 .
RefSeqi YP_495075.1. NC_007793.1.

3D structure databases

ProteinModelPortali Q2FE03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 451515.SAUSA300_2441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD21634 ; ABD21634 ; SAUSA300_2441 .
GeneIDi 3913735.
KEGGi saa:SAUSA300_2441.
PATRICi 19594471. VBIStaAur129981_2611.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000280272.
KOi K13732.
OMAi NKFTHVA.
OrthoDBi EOG69D37T.

Enzyme and pathway databases

BioCyci SAUR451515:GH3C-2441-MONOMER.

Miscellaneous databases

PROi Q2FE03.

Family and domain databases

Gene3Di 2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProi IPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR004237. Fibron_repeat-bd.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF02986. Fn_bind. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view ]
SUPFAMi SSF49401. SSF49401. 2 hits.
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiFNBA_STAA3
AccessioniPrimary (citable) accession number: Q2FE03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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