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Q2FE03

- FNBA_STAA3

UniProt

Q2FE03 - FNBA_STAA3

Protein

Fibronectin-binding protein A

Gene

fnbA

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin. This confers to S.aureus the ability to invade endothelial cells. Promotes adherence to and aggregation of activated platelets By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Virulence

    Enzyme and pathway databases

    BioCyciSAUR451515:GH3C-2441-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibronectin-binding protein A
    Gene namesi
    Name:fnbA
    Ordered Locus Names:SAUSA300_2441
    OrganismiStaphylococcus aureus (strain USA300)
    Taxonomic identifieri367830 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001939: Chromosome

    Subcellular locationi

    Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636Sequence AnalysisAdd
    BLAST
    Chaini37 – 985949Fibronectin-binding protein APRO_0000313874Add
    BLAST
    Propeptidei986 – 101833Removed by sortasePROSITE-ProRule annotationPRO_0000313875Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei985 – 9851Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    STRINGi451515.SAUSA300_2441.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2FE03.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati545 – 57430B-1Add
    BLAST
    Repeati575 – 60430B-2Add
    BLAST
    Repeati745 – 78238D-1Add
    BLAST
    Repeati783 – 82038D-2Add
    BLAST
    Repeati821 – 85939D-3Add
    BLAST
    Repeati860 – 87819D-4; truncatedAdd
    BLAST
    Repeati879 – 89214WR 1Add
    BLAST
    Repeati893 – 90614WR 2Add
    BLAST
    Repeati907 – 92014WR 3Add
    BLAST
    Repeati921 – 93414WR 4Add
    BLAST
    Repeati935 – 94814WR 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 511475Ligand-binding A regionAdd
    BLAST
    Regioni194 – 511318Fibrinogen/elastin/tropoelastin-bindingBy similarityAdd
    BLAST
    Regioni512 – 872361Fibronectin-bindingBy similarityAdd
    BLAST
    Regioni545 – 604602 X approximate tandem repeatsAdd
    BLAST
    Regioni745 – 8781344 X approximate tandem repeatsAdd
    BLAST
    Regioni879 – 948705 X tandem repeats, Pro-rich (WR)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi982 – 9865LPXTG sorting signalPROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000280272.
    KOiK13732.
    OMAiNKFTHVA.
    OrthoDBiEOG69D37T.

    Family and domain databases

    Gene3Di2.60.40.1280. 1 hit.
    2.60.40.1290. 1 hit.
    InterProiIPR011266. Adhesin_Fg-bd_dom_2.
    IPR008966. Adhesion_dom.
    IPR011252. Fibrogen-bd_dom1.
    IPR004237. Fibron_repeat-bd.
    IPR019948. Gram-positive_anchor.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PfamiPF02986. Fn_bind. 3 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF10425. SdrG_C_C. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view]
    SUPFAMiSSF49401. SSF49401. 2 hits.
    TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2FE03-1 [UniParc]FASTAAdd to Basket

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    MKNNLRYGIR KHKLGAASVF LGTMIVVGMG QDKEAAASEQ KTTTVEENGN     50
    SATDNKTSET QTTATNVNHI EETQSYNATV TEQPSNATQV TTEEAPKAVQ 100
    APQTAQPANI ETVKEEVVKE EAKPQVKETT QSQDNSGDQR QVDLTPKKAT 150
    QNQVAETQVE VAQPRTASES KPRVTRSADV AEAKEASNAK VETGTDVTSK 200
    VTVEIGSIEG HNNTNKVEPH AGQRAVLKYK LKFENGLHQG DYFDFTLSNN 250
    VNTHGVSTAR KVPEIKNGSV VMATGEVLEG GKIRYTFTND IEDKVDVTAE 300
    LEINLFIDPK TVQTNGNQTI TSTLNEEQTS KELDVKYKDG IGNYYANLNG 350
    SIETFNKANN RFSHVAFIKP NNGKTTSVTV TGTLMKGSNQ NGNQPKVRIF 400
    EYLGNNEDIA KSVYANTTDT SKFKEVTSNM SGNLNLQNNG SYSLNIENLD 450
    KTYVVHYDGE YLNGTDEVDF RTQMVGHPEQ LYKYYYDRGY TLTWDNGLVL 500
    YSNKANGNGK NGPIIQNNKF EYKEDTIKET LTGQYDKNLV TTVEEEYDSS 550
    TLDIDYHTAI DGGGGYVDGY IETIEETDSS AIDIDYHTAV DSEAGHVGGY 600
    TESSEESNPI DFEESTHENS KHHADVVEYE EDTNPGGGQV TTESNLVEFD 650
    EESTKGIVTG AVSDHTTVED TKEYTTESNL IELVDELPEE HGQAQGPVEE 700
    ITENNHHISH SGLGTENGHG NYDVIEEIEE NSHVDIKSEL GYEGGQNSGN 750
    QSFEEDTEED KPKYEQGGNI VDIDFDSVPQ IHGQNKGNQS FEEDTEKDKP 800
    KYEHGGNIID IDFDSVPHIH GFNKHTEIIE EDTNKDKPSY QFGGHNSVDF 850
    EEDTLPKVSG QNEGQQTIEE DTTPPIVPPT PPTPEVPSEP ETPTPPTPEV 900
    PSEPETPTPP TPEVPSEPET PTPPTPEVPA EPGKPVPPAK EEPKKPSKPV 950
    EQGKVVTPVI EINEKVKAVA PTKKPQSKKS ELPETGGEES TNKGMLFGGL 1000
    FSILGLALLR RNKKNHKA 1018
    Length:1,018
    Mass (Da):111,709
    Last modified:March 21, 2006 - v1
    Checksum:i9B215B90035EEA6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000255 Genomic DNA. Translation: ABD21634.1.
    RefSeqiYP_495075.1. NC_007793.1.

    Genome annotation databases

    EnsemblBacteriaiABD21634; ABD21634; SAUSA300_2441.
    GeneIDi3913735.
    KEGGisaa:SAUSA300_2441.
    PATRICi19594471. VBIStaAur129981_2611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000255 Genomic DNA. Translation: ABD21634.1 .
    RefSeqi YP_495075.1. NC_007793.1.

    3D structure databases

    ProteinModelPortali Q2FE03.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 451515.SAUSA300_2441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD21634 ; ABD21634 ; SAUSA300_2441 .
    GeneIDi 3913735.
    KEGGi saa:SAUSA300_2441.
    PATRICi 19594471. VBIStaAur129981_2611.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000280272.
    KOi K13732.
    OMAi NKFTHVA.
    OrthoDBi EOG69D37T.

    Enzyme and pathway databases

    BioCyci SAUR451515:GH3C-2441-MONOMER.

    Miscellaneous databases

    PROi Q2FE03.

    Family and domain databases

    Gene3Di 2.60.40.1280. 1 hit.
    2.60.40.1290. 1 hit.
    InterProi IPR011266. Adhesin_Fg-bd_dom_2.
    IPR008966. Adhesion_dom.
    IPR011252. Fibrogen-bd_dom1.
    IPR004237. Fibron_repeat-bd.
    IPR019948. Gram-positive_anchor.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    Pfami PF02986. Fn_bind. 3 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF10425. SdrG_C_C. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49401. SSF49401. 2 hits.
    TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
      Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
      Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: USA300.

    Entry informationi

    Entry nameiFNBA_STAA3
    AccessioniPrimary (citable) accession number: Q2FE03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3