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Q2FE03

- FNBA_STAA3

UniProt

Q2FE03 - FNBA_STAA3

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Protein

Fibronectin-binding protein A

Gene

fnbA

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin. This confers to S.aureus the ability to invade endothelial cells. Promotes adherence to and aggregation of activated platelets (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Virulence

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-2441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin-binding protein A
Gene namesi
Name:fnbA
Ordered Locus Names:SAUSA300_2441
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001939: Chromosome

Subcellular locationi

Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence AnalysisAdd
BLAST
Chaini37 – 985949Fibronectin-binding protein APRO_0000313874Add
BLAST
Propeptidei986 – 101833Removed by sortasePROSITE-ProRule annotationPRO_0000313875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei985 – 9851Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi451515.SAUSA300_2441.

Structurei

3D structure databases

ProteinModelPortaliQ2FE03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati545 – 57430B-1Add
BLAST
Repeati575 – 60430B-2Add
BLAST
Repeati745 – 78238D-1Add
BLAST
Repeati783 – 82038D-2Add
BLAST
Repeati821 – 85939D-3Add
BLAST
Repeati860 – 87819D-4; truncatedAdd
BLAST
Repeati879 – 89214WR 1Add
BLAST
Repeati893 – 90614WR 2Add
BLAST
Repeati907 – 92014WR 3Add
BLAST
Repeati921 – 93414WR 4Add
BLAST
Repeati935 – 94814WR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 511475Ligand-binding A regionAdd
BLAST
Regioni194 – 511318Fibrinogen/elastin/tropoelastin-bindingBy similarityAdd
BLAST
Regioni512 – 872361Fibronectin-bindingBy similarityAdd
BLAST
Regioni545 – 604602 X approximate tandem repeatsAdd
BLAST
Regioni745 – 8781344 X approximate tandem repeatsAdd
BLAST
Regioni879 – 948705 X tandem repeats, Pro-rich (WR)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi982 – 9865LPXTG sorting signalPROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000280272.
KOiK13732.
OMAiNKFTHVA.
OrthoDBiEOG69D37T.

Family and domain databases

Gene3Di2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProiIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR004237. Fibron_repeat-bd.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF02986. Fn_bind. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FE03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNNLRYGIR KHKLGAASVF LGTMIVVGMG QDKEAAASEQ KTTTVEENGN
60 70 80 90 100
SATDNKTSET QTTATNVNHI EETQSYNATV TEQPSNATQV TTEEAPKAVQ
110 120 130 140 150
APQTAQPANI ETVKEEVVKE EAKPQVKETT QSQDNSGDQR QVDLTPKKAT
160 170 180 190 200
QNQVAETQVE VAQPRTASES KPRVTRSADV AEAKEASNAK VETGTDVTSK
210 220 230 240 250
VTVEIGSIEG HNNTNKVEPH AGQRAVLKYK LKFENGLHQG DYFDFTLSNN
260 270 280 290 300
VNTHGVSTAR KVPEIKNGSV VMATGEVLEG GKIRYTFTND IEDKVDVTAE
310 320 330 340 350
LEINLFIDPK TVQTNGNQTI TSTLNEEQTS KELDVKYKDG IGNYYANLNG
360 370 380 390 400
SIETFNKANN RFSHVAFIKP NNGKTTSVTV TGTLMKGSNQ NGNQPKVRIF
410 420 430 440 450
EYLGNNEDIA KSVYANTTDT SKFKEVTSNM SGNLNLQNNG SYSLNIENLD
460 470 480 490 500
KTYVVHYDGE YLNGTDEVDF RTQMVGHPEQ LYKYYYDRGY TLTWDNGLVL
510 520 530 540 550
YSNKANGNGK NGPIIQNNKF EYKEDTIKET LTGQYDKNLV TTVEEEYDSS
560 570 580 590 600
TLDIDYHTAI DGGGGYVDGY IETIEETDSS AIDIDYHTAV DSEAGHVGGY
610 620 630 640 650
TESSEESNPI DFEESTHENS KHHADVVEYE EDTNPGGGQV TTESNLVEFD
660 670 680 690 700
EESTKGIVTG AVSDHTTVED TKEYTTESNL IELVDELPEE HGQAQGPVEE
710 720 730 740 750
ITENNHHISH SGLGTENGHG NYDVIEEIEE NSHVDIKSEL GYEGGQNSGN
760 770 780 790 800
QSFEEDTEED KPKYEQGGNI VDIDFDSVPQ IHGQNKGNQS FEEDTEKDKP
810 820 830 840 850
KYEHGGNIID IDFDSVPHIH GFNKHTEIIE EDTNKDKPSY QFGGHNSVDF
860 870 880 890 900
EEDTLPKVSG QNEGQQTIEE DTTPPIVPPT PPTPEVPSEP ETPTPPTPEV
910 920 930 940 950
PSEPETPTPP TPEVPSEPET PTPPTPEVPA EPGKPVPPAK EEPKKPSKPV
960 970 980 990 1000
EQGKVVTPVI EINEKVKAVA PTKKPQSKKS ELPETGGEES TNKGMLFGGL
1010
FSILGLALLR RNKKNHKA
Length:1,018
Mass (Da):111,709
Last modified:March 21, 2006 - v1
Checksum:i9B215B90035EEA6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21634.1.
RefSeqiYP_495075.1. NC_007793.1.

Genome annotation databases

EnsemblBacteriaiABD21634; ABD21634; SAUSA300_2441.
GeneIDi3913735.
KEGGisaa:SAUSA300_2441.
PATRICi19594471. VBIStaAur129981_2611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21634.1 .
RefSeqi YP_495075.1. NC_007793.1.

3D structure databases

ProteinModelPortali Q2FE03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 451515.SAUSA300_2441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD21634 ; ABD21634 ; SAUSA300_2441 .
GeneIDi 3913735.
KEGGi saa:SAUSA300_2441.
PATRICi 19594471. VBIStaAur129981_2611.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000280272.
KOi K13732.
OMAi NKFTHVA.
OrthoDBi EOG69D37T.

Enzyme and pathway databases

BioCyci SAUR451515:GH3C-2441-MONOMER.

Miscellaneous databases

PROi Q2FE03.

Family and domain databases

Gene3Di 2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProi IPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR004237. Fibron_repeat-bd.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF02986. Fn_bind. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view ]
SUPFAMi SSF49401. SSF49401. 2 hits.
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiFNBA_STAA3
AccessioniPrimary (citable) accession number: Q2FE03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3