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Q2FDM8

- ARCR_STAA3

UniProt

Q2FDM8 - ARCR_STAA3

Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 12990cNMPAdd
    BLAST
    DNA bindingi188 – 20720H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR451515:GH3C-2566-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator ArcR
    Gene namesi
    Name:arcR
    Ordered Locus Names:SAUSA300_2566
    OrganismiStaphylococcus aureus (strain USA300)
    Taxonomic identifieri367830 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001939: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234HTH-type transcriptional regulator ArcRPRO_0000349417Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi451515.SAUSA300_2566.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2FDM8.
    SMRiQ2FDM8. Positions 31-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini155 – 22874HTH crp-typeAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000022896.
    OMAiERVNQNG.
    OrthoDBiEOG6QRWC5.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2FDM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY    50
    FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV 100
    NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM 150
    ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE 200
    TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV 234
    Length:234
    Mass (Da):27,428
    Last modified:March 21, 2006 - v1
    Checksum:iA26B08D8A1EA396E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000255 Genomic DNA. Translation: ABD22163.1.
    RefSeqiYP_495200.1. NC_007793.1.

    Genome annotation databases

    EnsemblBacteriaiABD22163; ABD22163; SAUSA300_2566.
    GeneIDi3914440.
    KEGGisaa:SAUSA300_2566.
    PATRICi19594741. VBIStaAur129981_2746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000255 Genomic DNA. Translation: ABD22163.1 .
    RefSeqi YP_495200.1. NC_007793.1.

    3D structure databases

    ProteinModelPortali Q2FDM8.
    SMRi Q2FDM8. Positions 31-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 451515.SAUSA300_2566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD22163 ; ABD22163 ; SAUSA300_2566 .
    GeneIDi 3914440.
    KEGGi saa:SAUSA300_2566.
    PATRICi 19594741. VBIStaAur129981_2746.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000022896.
    OMAi ERVNQNG.
    OrthoDBi EOG6QRWC5.

    Enzyme and pathway databases

    BioCyci SAUR451515:GH3C-2566-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
      Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
      Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: USA300.

    Entry informationi

    Entry nameiARCR_STAA3
    AccessioniPrimary (citable) accession number: Q2FDM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3