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Protein

Serine-rich adhesin for platelets

Gene

sraP

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-2589-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-rich adhesin for platelets
Alternative name(s):
Staphylococcus aureus surface protein A
Gene namesi
Name:sraP
Ordered Locus Names:SAUSA300_2589
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001939 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22322232Serine-rich adhesin for plateletsPRO_0000273934Add
BLAST
Propeptidei2233 – 227139Removed by sortasePROSITE-ProRule annotationPRO_0000273935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2232 – 22321Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Post-translational modificationi

Proteolytically cleaved by a metalloprotease.By similarity
Glycosylated.By similarity

Keywords - PTMi

Peptidoglycan-anchor

Structurei

3D structure databases

ProteinModelPortaliQ2FDK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2229 – 22335LPXTG sorting signalPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 743647Thr-richAdd
BLAST
Compositional biasi752 – 22131462Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the SraP family.Curated

Phylogenomic databases

HOGENOMiHOG000280317.
OMAiSSIPESN.
OrthoDBiEOG6WX4ST.

Family and domain databases

InterProiIPR015919. Cadherin-like.
IPR013320. ConA-like_dom.
IPR019948. Gram-positive_anchor.
IPR022263. KxYKxGKxW.
IPR019931. LPXTG_anchor.
[Graphical view]
PfamiPF00746. Gram_pos_anchor. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
TIGRFAMsiTIGR03715. KxYKxGKxW. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FDK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRQKAFHD SLANEKTRVR LYKSGKNWVK SGIKEIEMFK IMGLPFISHS
60 70 80 90 100
LVSQDNQSIS KKMTGYGLKT TAVIGGAFTV NMLHDQQAFA ASDAPLTSEL
110 120 130 140 150
NTQSETVGNQ NSTTIEASTS TADSTSVTKN SSSVQTSNSD TVSSEKSEKV
160 170 180 190 200
TSTTNSTSNQ QEKLTSTSES TSSKNTTSSS DTKSVASTSS TEQPINTSTN
210 220 230 240 250
QSTASNNTSQ STTPSSVNLN KTSTTSTSTA PVKLRTFSRL AMSTFASAAT
260 270 280 290 300
TTAVTANTIT VNKDNLKQYM TTSGNATYDQ STGIVTLTQD AYSQKGAITL
310 320 330 340 350
GTRIDSNKSF HFSGKVNLGN KYEGHGNGGD GIGFAFSPGV LGETGLNGAA
360 370 380 390 400
VGIGGLSNAF GFKLDTYHNT SKPNSAAKAN ADPSNVAGGG AFGAFVTTDS
410 420 430 440 450
YGVATTYTSS STADNAAKLN VQPTNNTFQD FDINYNGDTK VMTVKYAGQT
460 470 480 490 500
WTRNISDWIA KSGTTNFSLS MTASTGGATN LQQVQFGTFE YTESAVTQVR
510 520 530 540 550
YVDVTTGKDI IPPKTYSGNV DQVVTIDNQQ SALTAKGYNY TSVDSSYAST
560 570 580 590 600
YNDTNKTVKM TNAGQSVTYY FTDVKAPTVT VGNQTIEVGK TMNPIVLTTT
610 620 630 640 650
DNGTGTVTNT VTGLPSGLSY DSATNSIIGT PTKIGQSTVT VVSTDQANNK
660 670 680 690 700
STTTFTINVV DTTAPTVTPI GDQSSEVYSP ISPIKIATQD NSGNAVTNTV
710 720 730 740 750
TGLPSGLTFD STNNTISGTP TNIGTSTISI VSTDASGNKT TTTFKYEVTR
760 770 780 790 800
NSMSDSVSTS GSTQQSQSVS TSKADSQSAS TSTSGSIVVS TSASTSKSTS
810 820 830 840 850
VSLSDSVSAS KSLSTSESNS VSSSTSTSLV NSQSVSSSMS DSASKSTSLS
860 870 880 890 900
DSISNSSSTE KSESLSTSTS DSLRTSTSLS DSLSMSTSGS LSKSQSLSTS
910 920 930 940 950
ISGSSSTSAS LSDSTSNAIS TSTSLSESAS TSDSISISNS IANSQSASTS
960 970 980 990 1000
KSDSQSTSIS LSTSDSKSMS TSESLSDSTS TSGSVSGSLS IAASQSVSTS
1010 1020 1030 1040 1050
TSDSMSTSEI VSDSISTSGS LSASDSKSMS VSSSMSTSQS GSTSESLSDS
1060 1070 1080 1090 1100
QSTSDSDSKS LSQSTSQSGS TSTSTSTSAS VRTSESQSTS GSMSASQSDS
1110 1120 1130 1140 1150
MSISTSFSDS TSDSKSASTA SSESISQSAF TSTSGSVSTS TSLSTSNSER
1160 1170 1180 1190 1200
TSTSMSDSTS LSTSESDSIS ESTSTSDSIS EAISASESTF ISLSESNSTS
1210 1220 1230 1240 1250
DSESQSASAF LSESLSESTS ESTSESVSSS TSESTSLSDS TSESGSTSTS
1260 1270 1280 1290 1300
LSNSTSGSTS ISTSTSISES TSTFKSESVS TSLSMSTSTS LSDSTSLSTS
1310 1320 1330 1340 1350
LSDSTSDSKS DSLSTSMSTS DSISTSKSDS ISTSTSLSGS TSESESDSTS
1360 1370 1380 1390 1400
SSESKSDSTS MSISMSQSTS GSTSTSTSTS LSDSTSTSLS LSASMNQSGV
1410 1420 1430 1440 1450
DSNSASQSAS NSTSTSTSES DSQSTSSYTS QSTSQSESTS TSTSLSDSTS
1460 1470 1480 1490 1500
ISKSTSQSGS VSTSASLSGS ESESDSQSIS TSASESTSES ASTSLSDSTS
1510 1520 1530 1540 1550
TSNSGSASTS TSLSNSASAS ESDLSSTSLS DSTSASMQSS ESDSQSTSAS
1560 1570 1580 1590 1600
LSDSLSTSTS NRMSTIASLS TSVSTSESGS TSESTSESDS TSTSLSDSQS
1610 1620 1630 1640 1650
TSRSTSASGS ASTSTSTSDS RSTSASTSTS MRTSTSDSQS MSLSTSTSTS
1660 1670 1680 1690 1700
MSDSTSLSDS VSDSTSDSTS ASTSGSMSVS ISLSDSTSTS TSASEVMSAS
1710 1720 1730 1740 1750
ISDSQSMSES VNDSESVSES NSESDSKSMS GSTSVSDSGS LSVSTSLRKS
1760 1770 1780 1790 1800
ESVSESSSLS CSQSMSDSVS TSDSSSLSVS TSLRSSESVS ESDSLSDSKS
1810 1820 1830 1840 1850
TSGSTSTSTS GSLSTSTSLS GSESVSESTS LSDSISMSDS TSTSDSDSLS
1860 1870 1880 1890 1900
GSISLSGSTS LSTSDSLSDS KSLSSSQSMS GSESTSTSVS DSQSSSTSNS
1910 1920 1930 1940 1950
QFDSMSISAS ESDSMSTSDS SSISGSNSTS TSLSTSDSMS GSVSVSTSTS
1960 1970 1980 1990 2000
LSDSISGSTS VSDSSSTSTS TSLSDSMSQS QSTSTSASGS LSTSISTSMS
2010 2020 2030 2040 2050
MSASTSSSQS TSVSTSLSTS DSISDSTSIS ISGSQSTVES ESTSDSTSIS
2060 2070 2080 2090 2100
DSESLSTSDS DSTSTSTSDS TSGSTSTSIS ESLSTSGSGS TSVSDSTSMS
2110 2120 2130 2140 2150
ESNSSSVSMS QDKSDSTSIS DSESVSTSTS TSLSTSDSTS TSESLSTSMS
2160 2170 2180 2190 2200
GSQSISDSTS TSMSGSTSTS ESNSMHPSDS MSMHHTHSTS TSRLSSEATT
2210 2220 2230 2240 2250
STSESQSTLS ATSEVTKHNG TPAQSEKRLP DTGDSIKQNG LLGGVMTLLV
2260 2270
GLGLMKRKKK KDENDQDDSQ A
Length:2,271
Mass (Da):228,077
Last modified:March 21, 2006 - v1
Checksum:i7E4A545A443EC5EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21900.1.

Genome annotation databases

EnsemblBacteriaiABD21900; ABD21900; SAUSA300_2589.
KEGGisaa:SAUSA300_2589.
PATRICi19594787. VBIStaAur129981_2769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD21900.1.

3D structure databases

ProteinModelPortaliQ2FDK5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD21900; ABD21900; SAUSA300_2589.
KEGGisaa:SAUSA300_2589.
PATRICi19594787. VBIStaAur129981_2769.

Phylogenomic databases

HOGENOMiHOG000280317.
OMAiSSIPESN.
OrthoDBiEOG6WX4ST.

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-2589-MONOMER.

Family and domain databases

InterProiIPR015919. Cadherin-like.
IPR013320. ConA-like_dom.
IPR019948. Gram-positive_anchor.
IPR022263. KxYKxGKxW.
IPR019931. LPXTG_anchor.
[Graphical view]
PfamiPF00746. Gram_pos_anchor. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
TIGRFAMsiTIGR03715. KxYKxGKxW. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiSRAP_STAA3
AccessioniPrimary (citable) accession number: Q2FDK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 21, 2006
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.