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Q2FDK5 (SRAP_STAA3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine-rich adhesin for platelets
Alternative name(s):
Staphylococcus aureus surface protein A
Gene names
Name:sraP
Ordered Locus Names:SAUSA300_2589
OrganismStaphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]
Taxonomic identifier367830 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length2271 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection By similarity.

Subcellular location

Secreted › cell wall; Peptidoglycan-anchor. Note: Possibly exported by the accessory SecA2/SecY2 system By similarity.

Post-translational modification

Proteolytically cleaved by a metalloprotease By similarity.

Glycosylated By similarity.

Sequence similarities

Belongs to the SraP family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell wall
Secreted
   PTMPeptidoglycan-anchor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22322232Serine-rich adhesin for platelets
PRO_0000273934
Propeptide2233 – 227139Removed by sortase Potential
PRO_0000273935

Regions

Motif2229 – 22335LPXTG sorting signal Potential
Compositional bias97 – 743647Thr-rich
Compositional bias752 – 22131462Ser-rich

Amino acid modifications

Modified residue22321Pentaglycyl murein peptidoglycan amidated threonine Potential

Sequences

Sequence LengthMass (Da)Tools
Q2FDK5 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 7E4A545A443EC5EA

FASTA2,271228,077
        10         20         30         40         50         60 
MSKRQKAFHD SLANEKTRVR LYKSGKNWVK SGIKEIEMFK IMGLPFISHS LVSQDNQSIS 

        70         80         90        100        110        120 
KKMTGYGLKT TAVIGGAFTV NMLHDQQAFA ASDAPLTSEL NTQSETVGNQ NSTTIEASTS 

       130        140        150        160        170        180 
TADSTSVTKN SSSVQTSNSD TVSSEKSEKV TSTTNSTSNQ QEKLTSTSES TSSKNTTSSS 

       190        200        210        220        230        240 
DTKSVASTSS TEQPINTSTN QSTASNNTSQ STTPSSVNLN KTSTTSTSTA PVKLRTFSRL 

       250        260        270        280        290        300 
AMSTFASAAT TTAVTANTIT VNKDNLKQYM TTSGNATYDQ STGIVTLTQD AYSQKGAITL 

       310        320        330        340        350        360 
GTRIDSNKSF HFSGKVNLGN KYEGHGNGGD GIGFAFSPGV LGETGLNGAA VGIGGLSNAF 

       370        380        390        400        410        420 
GFKLDTYHNT SKPNSAAKAN ADPSNVAGGG AFGAFVTTDS YGVATTYTSS STADNAAKLN 

       430        440        450        460        470        480 
VQPTNNTFQD FDINYNGDTK VMTVKYAGQT WTRNISDWIA KSGTTNFSLS MTASTGGATN 

       490        500        510        520        530        540 
LQQVQFGTFE YTESAVTQVR YVDVTTGKDI IPPKTYSGNV DQVVTIDNQQ SALTAKGYNY 

       550        560        570        580        590        600 
TSVDSSYAST YNDTNKTVKM TNAGQSVTYY FTDVKAPTVT VGNQTIEVGK TMNPIVLTTT 

       610        620        630        640        650        660 
DNGTGTVTNT VTGLPSGLSY DSATNSIIGT PTKIGQSTVT VVSTDQANNK STTTFTINVV 

       670        680        690        700        710        720 
DTTAPTVTPI GDQSSEVYSP ISPIKIATQD NSGNAVTNTV TGLPSGLTFD STNNTISGTP 

       730        740        750        760        770        780 
TNIGTSTISI VSTDASGNKT TTTFKYEVTR NSMSDSVSTS GSTQQSQSVS TSKADSQSAS 

       790        800        810        820        830        840 
TSTSGSIVVS TSASTSKSTS VSLSDSVSAS KSLSTSESNS VSSSTSTSLV NSQSVSSSMS 

       850        860        870        880        890        900 
DSASKSTSLS DSISNSSSTE KSESLSTSTS DSLRTSTSLS DSLSMSTSGS LSKSQSLSTS 

       910        920        930        940        950        960 
ISGSSSTSAS LSDSTSNAIS TSTSLSESAS TSDSISISNS IANSQSASTS KSDSQSTSIS 

       970        980        990       1000       1010       1020 
LSTSDSKSMS TSESLSDSTS TSGSVSGSLS IAASQSVSTS TSDSMSTSEI VSDSISTSGS 

      1030       1040       1050       1060       1070       1080 
LSASDSKSMS VSSSMSTSQS GSTSESLSDS QSTSDSDSKS LSQSTSQSGS TSTSTSTSAS 

      1090       1100       1110       1120       1130       1140 
VRTSESQSTS GSMSASQSDS MSISTSFSDS TSDSKSASTA SSESISQSAF TSTSGSVSTS 

      1150       1160       1170       1180       1190       1200 
TSLSTSNSER TSTSMSDSTS LSTSESDSIS ESTSTSDSIS EAISASESTF ISLSESNSTS 

      1210       1220       1230       1240       1250       1260 
DSESQSASAF LSESLSESTS ESTSESVSSS TSESTSLSDS TSESGSTSTS LSNSTSGSTS 

      1270       1280       1290       1300       1310       1320 
ISTSTSISES TSTFKSESVS TSLSMSTSTS LSDSTSLSTS LSDSTSDSKS DSLSTSMSTS 

      1330       1340       1350       1360       1370       1380 
DSISTSKSDS ISTSTSLSGS TSESESDSTS SSESKSDSTS MSISMSQSTS GSTSTSTSTS 

      1390       1400       1410       1420       1430       1440 
LSDSTSTSLS LSASMNQSGV DSNSASQSAS NSTSTSTSES DSQSTSSYTS QSTSQSESTS 

      1450       1460       1470       1480       1490       1500 
TSTSLSDSTS ISKSTSQSGS VSTSASLSGS ESESDSQSIS TSASESTSES ASTSLSDSTS 

      1510       1520       1530       1540       1550       1560 
TSNSGSASTS TSLSNSASAS ESDLSSTSLS DSTSASMQSS ESDSQSTSAS LSDSLSTSTS 

      1570       1580       1590       1600       1610       1620 
NRMSTIASLS TSVSTSESGS TSESTSESDS TSTSLSDSQS TSRSTSASGS ASTSTSTSDS 

      1630       1640       1650       1660       1670       1680 
RSTSASTSTS MRTSTSDSQS MSLSTSTSTS MSDSTSLSDS VSDSTSDSTS ASTSGSMSVS 

      1690       1700       1710       1720       1730       1740 
ISLSDSTSTS TSASEVMSAS ISDSQSMSES VNDSESVSES NSESDSKSMS GSTSVSDSGS 

      1750       1760       1770       1780       1790       1800 
LSVSTSLRKS ESVSESSSLS CSQSMSDSVS TSDSSSLSVS TSLRSSESVS ESDSLSDSKS 

      1810       1820       1830       1840       1850       1860 
TSGSTSTSTS GSLSTSTSLS GSESVSESTS LSDSISMSDS TSTSDSDSLS GSISLSGSTS 

      1870       1880       1890       1900       1910       1920 
LSTSDSLSDS KSLSSSQSMS GSESTSTSVS DSQSSSTSNS QFDSMSISAS ESDSMSTSDS 

      1930       1940       1950       1960       1970       1980 
SSISGSNSTS TSLSTSDSMS GSVSVSTSTS LSDSISGSTS VSDSSSTSTS TSLSDSMSQS 

      1990       2000       2010       2020       2030       2040 
QSTSTSASGS LSTSISTSMS MSASTSSSQS TSVSTSLSTS DSISDSTSIS ISGSQSTVES 

      2050       2060       2070       2080       2090       2100 
ESTSDSTSIS DSESLSTSDS DSTSTSTSDS TSGSTSTSIS ESLSTSGSGS TSVSDSTSMS 

      2110       2120       2130       2140       2150       2160 
ESNSSSVSMS QDKSDSTSIS DSESVSTSTS TSLSTSDSTS TSESLSTSMS GSQSISDSTS 

      2170       2180       2190       2200       2210       2220 
TSMSGSTSTS ESNSMHPSDS MSMHHTHSTS TSRLSSEATT STSESQSTLS ATSEVTKHNG 

      2230       2240       2250       2260       2270 
TPAQSEKRLP DTGDSIKQNG LLGGVMTLLV GLGLMKRKKK KDENDQDDSQ A

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References

[1]"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USA300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000255 Genomic DNA. Translation: ABD21900.1.
RefSeqYP_495223.1. NC_007793.1.

3D structure databases

ProteinModelPortalQ2FDK5.
ModBaseSearch...

Protein-protein interaction databases

STRING451515.SAUSA300_2589.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD21900; ABD21900; SAUSA300_2589.
GeneID3914100.
KEGGsaa:SAUSA300_2589.
PATRIC19594787. VBIStaAur129981_2769.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000280317.
OMAASNINAQ.
ProtClustDBCLSK886133.

Enzyme and pathway databases

BioCycSAUR451515:GH3C-2589-MONOMER.

Family and domain databases

InterProIPR015919. Cadherin-like.
IPR008985. ConA-like_lec_gl_sf.
IPR019948. Gram-positive_anchor.
IPR022263. KxYKxGKxW.
IPR019931. LPXTG-motif_cell_wall_anchor.
[Graphical view]
PfamPF00746. Gram_pos_anchor. 1 hit.
[Graphical view]
SUPFAMSSF49313. Cadherin. 2 hits.
SSF49899. ConA_like_lec_gl. 1 hit.
TIGRFAMsTIGR03715. KxYKxGKxW. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
PROSITEPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRAP_STAA3
AccessionPrimary (citable) accession number: Q2FDK5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 21, 2006
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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