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Q2FDK5

- SRAP_STAA3

UniProt

Q2FDK5 - SRAP_STAA3

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Protein
Serine-rich adhesin for platelets
Gene
sraP, SAUSA300_2589
Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-2589-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-rich adhesin for platelets
Alternative name(s):
Staphylococcus aureus surface protein A
Gene namesi
Name:sraP
Ordered Locus Names:SAUSA300_2589
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001939: Chromosome

Subcellular locationi

Secretedcell wall; Peptidoglycan-anchor
Note: Possibly exported by the accessory SecA2/SecY2 system By similarity.

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22322232Serine-rich adhesin for platelets
PRO_0000273934Add
BLAST
Propeptidei2233 – 227139Removed by sortase Reviewed prediction
PRO_0000273935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2232 – 22321Pentaglycyl murein peptidoglycan amidated threonine Reviewed prediction

Post-translational modificationi

Proteolytically cleaved by a metalloprotease By similarity.
Glycosylated By similarity.

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi451515.SAUSA300_2589.

Structurei

3D structure databases

ProteinModelPortaliQ2FDK5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2229 – 22335LPXTG sorting signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 743647Thr-rich
Add
BLAST
Compositional biasi752 – 22131462Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the SraP family.

Phylogenomic databases

HOGENOMiHOG000280317.
OMAiINNGGPV.
OrthoDBiEOG6WX4ST.

Family and domain databases

InterProiIPR015919. Cadherin-like.
IPR008985. ConA-like_lec_gl_sf.
IPR019948. Gram-positive_anchor.
IPR022263. KxYKxGKxW.
IPR019931. LPXTG_anchor.
[Graphical view]
PfamiPF00746. Gram_pos_anchor. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
TIGRFAMsiTIGR03715. KxYKxGKxW. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FDK5-1 [UniParc]FASTAAdd to Basket

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MSKRQKAFHD SLANEKTRVR LYKSGKNWVK SGIKEIEMFK IMGLPFISHS     50
LVSQDNQSIS KKMTGYGLKT TAVIGGAFTV NMLHDQQAFA ASDAPLTSEL 100
NTQSETVGNQ NSTTIEASTS TADSTSVTKN SSSVQTSNSD TVSSEKSEKV 150
TSTTNSTSNQ QEKLTSTSES TSSKNTTSSS DTKSVASTSS TEQPINTSTN 200
QSTASNNTSQ STTPSSVNLN KTSTTSTSTA PVKLRTFSRL AMSTFASAAT 250
TTAVTANTIT VNKDNLKQYM TTSGNATYDQ STGIVTLTQD AYSQKGAITL 300
GTRIDSNKSF HFSGKVNLGN KYEGHGNGGD GIGFAFSPGV LGETGLNGAA 350
VGIGGLSNAF GFKLDTYHNT SKPNSAAKAN ADPSNVAGGG AFGAFVTTDS 400
YGVATTYTSS STADNAAKLN VQPTNNTFQD FDINYNGDTK VMTVKYAGQT 450
WTRNISDWIA KSGTTNFSLS MTASTGGATN LQQVQFGTFE YTESAVTQVR 500
YVDVTTGKDI IPPKTYSGNV DQVVTIDNQQ SALTAKGYNY TSVDSSYAST 550
YNDTNKTVKM TNAGQSVTYY FTDVKAPTVT VGNQTIEVGK TMNPIVLTTT 600
DNGTGTVTNT VTGLPSGLSY DSATNSIIGT PTKIGQSTVT VVSTDQANNK 650
STTTFTINVV DTTAPTVTPI GDQSSEVYSP ISPIKIATQD NSGNAVTNTV 700
TGLPSGLTFD STNNTISGTP TNIGTSTISI VSTDASGNKT TTTFKYEVTR 750
NSMSDSVSTS GSTQQSQSVS TSKADSQSAS TSTSGSIVVS TSASTSKSTS 800
VSLSDSVSAS KSLSTSESNS VSSSTSTSLV NSQSVSSSMS DSASKSTSLS 850
DSISNSSSTE KSESLSTSTS DSLRTSTSLS DSLSMSTSGS LSKSQSLSTS 900
ISGSSSTSAS LSDSTSNAIS TSTSLSESAS TSDSISISNS IANSQSASTS 950
KSDSQSTSIS LSTSDSKSMS TSESLSDSTS TSGSVSGSLS IAASQSVSTS 1000
TSDSMSTSEI VSDSISTSGS LSASDSKSMS VSSSMSTSQS GSTSESLSDS 1050
QSTSDSDSKS LSQSTSQSGS TSTSTSTSAS VRTSESQSTS GSMSASQSDS 1100
MSISTSFSDS TSDSKSASTA SSESISQSAF TSTSGSVSTS TSLSTSNSER 1150
TSTSMSDSTS LSTSESDSIS ESTSTSDSIS EAISASESTF ISLSESNSTS 1200
DSESQSASAF LSESLSESTS ESTSESVSSS TSESTSLSDS TSESGSTSTS 1250
LSNSTSGSTS ISTSTSISES TSTFKSESVS TSLSMSTSTS LSDSTSLSTS 1300
LSDSTSDSKS DSLSTSMSTS DSISTSKSDS ISTSTSLSGS TSESESDSTS 1350
SSESKSDSTS MSISMSQSTS GSTSTSTSTS LSDSTSTSLS LSASMNQSGV 1400
DSNSASQSAS NSTSTSTSES DSQSTSSYTS QSTSQSESTS TSTSLSDSTS 1450
ISKSTSQSGS VSTSASLSGS ESESDSQSIS TSASESTSES ASTSLSDSTS 1500
TSNSGSASTS TSLSNSASAS ESDLSSTSLS DSTSASMQSS ESDSQSTSAS 1550
LSDSLSTSTS NRMSTIASLS TSVSTSESGS TSESTSESDS TSTSLSDSQS 1600
TSRSTSASGS ASTSTSTSDS RSTSASTSTS MRTSTSDSQS MSLSTSTSTS 1650
MSDSTSLSDS VSDSTSDSTS ASTSGSMSVS ISLSDSTSTS TSASEVMSAS 1700
ISDSQSMSES VNDSESVSES NSESDSKSMS GSTSVSDSGS LSVSTSLRKS 1750
ESVSESSSLS CSQSMSDSVS TSDSSSLSVS TSLRSSESVS ESDSLSDSKS 1800
TSGSTSTSTS GSLSTSTSLS GSESVSESTS LSDSISMSDS TSTSDSDSLS 1850
GSISLSGSTS LSTSDSLSDS KSLSSSQSMS GSESTSTSVS DSQSSSTSNS 1900
QFDSMSISAS ESDSMSTSDS SSISGSNSTS TSLSTSDSMS GSVSVSTSTS 1950
LSDSISGSTS VSDSSSTSTS TSLSDSMSQS QSTSTSASGS LSTSISTSMS 2000
MSASTSSSQS TSVSTSLSTS DSISDSTSIS ISGSQSTVES ESTSDSTSIS 2050
DSESLSTSDS DSTSTSTSDS TSGSTSTSIS ESLSTSGSGS TSVSDSTSMS 2100
ESNSSSVSMS QDKSDSTSIS DSESVSTSTS TSLSTSDSTS TSESLSTSMS 2150
GSQSISDSTS TSMSGSTSTS ESNSMHPSDS MSMHHTHSTS TSRLSSEATT 2200
STSESQSTLS ATSEVTKHNG TPAQSEKRLP DTGDSIKQNG LLGGVMTLLV 2250
GLGLMKRKKK KDENDQDDSQ A 2271
Length:2,271
Mass (Da):228,077
Last modified:March 21, 2006 - v1
Checksum:i7E4A545A443EC5EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD21900.1.
RefSeqiYP_495223.1. NC_007793.1.

Genome annotation databases

EnsemblBacteriaiABD21900; ABD21900; SAUSA300_2589.
GeneIDi3914100.
KEGGisaa:SAUSA300_2589.
PATRICi19594787. VBIStaAur129981_2769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000255 Genomic DNA. Translation: ABD21900.1 .
RefSeqi YP_495223.1. NC_007793.1.

3D structure databases

ProteinModelPortali Q2FDK5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 451515.SAUSA300_2589.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD21900 ; ABD21900 ; SAUSA300_2589 .
GeneIDi 3914100.
KEGGi saa:SAUSA300_2589.
PATRICi 19594787. VBIStaAur129981_2769.

Phylogenomic databases

HOGENOMi HOG000280317.
OMAi INNGGPV.
OrthoDBi EOG6WX4ST.

Enzyme and pathway databases

BioCyci SAUR451515:GH3C-2589-MONOMER.

Family and domain databases

InterProi IPR015919. Cadherin-like.
IPR008985. ConA-like_lec_gl_sf.
IPR019948. Gram-positive_anchor.
IPR022263. KxYKxGKxW.
IPR019931. LPXTG_anchor.
[Graphical view ]
Pfami PF00746. Gram_pos_anchor. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
TIGRFAMsi TIGR03715. KxYKxGKxW. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiSRAP_STAA3
AccessioniPrimary (citable) accession number: Q2FDK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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