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Q2FDK5

- SRAP_STAA3

UniProt

Q2FDK5 - SRAP_STAA3

Protein

Serine-rich adhesin for platelets

Gene

sraP

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciSAUR451515:GH3C-2589-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine-rich adhesin for platelets
    Alternative name(s):
    Staphylococcus aureus surface protein A
    Gene namesi
    Name:sraP
    Ordered Locus Names:SAUSA300_2589
    OrganismiStaphylococcus aureus (strain USA300)
    Taxonomic identifieri367830 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001939: Chromosome

    Subcellular locationi

    Secretedcell wall; Peptidoglycan-anchor
    Note: Possibly exported by the accessory SecA2/SecY2 system.By similarity

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22322232Serine-rich adhesin for plateletsPRO_0000273934Add
    BLAST
    Propeptidei2233 – 227139Removed by sortasePROSITE-ProRule annotationPRO_0000273935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2232 – 22321Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

    Post-translational modificationi

    Proteolytically cleaved by a metalloprotease.By similarity
    Glycosylated.By similarity

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    STRINGi451515.SAUSA300_2589.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2FDK5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi2229 – 22335LPXTG sorting signalPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi97 – 743647Thr-richAdd
    BLAST
    Compositional biasi752 – 22131462Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SraP family.Curated

    Phylogenomic databases

    HOGENOMiHOG000280317.
    OMAiINNGGPV.
    OrthoDBiEOG6WX4ST.

    Family and domain databases

    InterProiIPR015919. Cadherin-like.
    IPR008985. ConA-like_lec_gl_sf.
    IPR019948. Gram-positive_anchor.
    IPR022263. KxYKxGKxW.
    IPR019931. LPXTG_anchor.
    [Graphical view]
    PfamiPF00746. Gram_pos_anchor. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 2 hits.
    SSF49899. SSF49899. 1 hit.
    TIGRFAMsiTIGR03715. KxYKxGKxW. 1 hit.
    TIGR01167. LPXTG_anchor. 1 hit.
    PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2FDK5-1 [UniParc]FASTAAdd to Basket

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    MSKRQKAFHD SLANEKTRVR LYKSGKNWVK SGIKEIEMFK IMGLPFISHS     50
    LVSQDNQSIS KKMTGYGLKT TAVIGGAFTV NMLHDQQAFA ASDAPLTSEL 100
    NTQSETVGNQ NSTTIEASTS TADSTSVTKN SSSVQTSNSD TVSSEKSEKV 150
    TSTTNSTSNQ QEKLTSTSES TSSKNTTSSS DTKSVASTSS TEQPINTSTN 200
    QSTASNNTSQ STTPSSVNLN KTSTTSTSTA PVKLRTFSRL AMSTFASAAT 250
    TTAVTANTIT VNKDNLKQYM TTSGNATYDQ STGIVTLTQD AYSQKGAITL 300
    GTRIDSNKSF HFSGKVNLGN KYEGHGNGGD GIGFAFSPGV LGETGLNGAA 350
    VGIGGLSNAF GFKLDTYHNT SKPNSAAKAN ADPSNVAGGG AFGAFVTTDS 400
    YGVATTYTSS STADNAAKLN VQPTNNTFQD FDINYNGDTK VMTVKYAGQT 450
    WTRNISDWIA KSGTTNFSLS MTASTGGATN LQQVQFGTFE YTESAVTQVR 500
    YVDVTTGKDI IPPKTYSGNV DQVVTIDNQQ SALTAKGYNY TSVDSSYAST 550
    YNDTNKTVKM TNAGQSVTYY FTDVKAPTVT VGNQTIEVGK TMNPIVLTTT 600
    DNGTGTVTNT VTGLPSGLSY DSATNSIIGT PTKIGQSTVT VVSTDQANNK 650
    STTTFTINVV DTTAPTVTPI GDQSSEVYSP ISPIKIATQD NSGNAVTNTV 700
    TGLPSGLTFD STNNTISGTP TNIGTSTISI VSTDASGNKT TTTFKYEVTR 750
    NSMSDSVSTS GSTQQSQSVS TSKADSQSAS TSTSGSIVVS TSASTSKSTS 800
    VSLSDSVSAS KSLSTSESNS VSSSTSTSLV NSQSVSSSMS DSASKSTSLS 850
    DSISNSSSTE KSESLSTSTS DSLRTSTSLS DSLSMSTSGS LSKSQSLSTS 900
    ISGSSSTSAS LSDSTSNAIS TSTSLSESAS TSDSISISNS IANSQSASTS 950
    KSDSQSTSIS LSTSDSKSMS TSESLSDSTS TSGSVSGSLS IAASQSVSTS 1000
    TSDSMSTSEI VSDSISTSGS LSASDSKSMS VSSSMSTSQS GSTSESLSDS 1050
    QSTSDSDSKS LSQSTSQSGS TSTSTSTSAS VRTSESQSTS GSMSASQSDS 1100
    MSISTSFSDS TSDSKSASTA SSESISQSAF TSTSGSVSTS TSLSTSNSER 1150
    TSTSMSDSTS LSTSESDSIS ESTSTSDSIS EAISASESTF ISLSESNSTS 1200
    DSESQSASAF LSESLSESTS ESTSESVSSS TSESTSLSDS TSESGSTSTS 1250
    LSNSTSGSTS ISTSTSISES TSTFKSESVS TSLSMSTSTS LSDSTSLSTS 1300
    LSDSTSDSKS DSLSTSMSTS DSISTSKSDS ISTSTSLSGS TSESESDSTS 1350
    SSESKSDSTS MSISMSQSTS GSTSTSTSTS LSDSTSTSLS LSASMNQSGV 1400
    DSNSASQSAS NSTSTSTSES DSQSTSSYTS QSTSQSESTS TSTSLSDSTS 1450
    ISKSTSQSGS VSTSASLSGS ESESDSQSIS TSASESTSES ASTSLSDSTS 1500
    TSNSGSASTS TSLSNSASAS ESDLSSTSLS DSTSASMQSS ESDSQSTSAS 1550
    LSDSLSTSTS NRMSTIASLS TSVSTSESGS TSESTSESDS TSTSLSDSQS 1600
    TSRSTSASGS ASTSTSTSDS RSTSASTSTS MRTSTSDSQS MSLSTSTSTS 1650
    MSDSTSLSDS VSDSTSDSTS ASTSGSMSVS ISLSDSTSTS TSASEVMSAS 1700
    ISDSQSMSES VNDSESVSES NSESDSKSMS GSTSVSDSGS LSVSTSLRKS 1750
    ESVSESSSLS CSQSMSDSVS TSDSSSLSVS TSLRSSESVS ESDSLSDSKS 1800
    TSGSTSTSTS GSLSTSTSLS GSESVSESTS LSDSISMSDS TSTSDSDSLS 1850
    GSISLSGSTS LSTSDSLSDS KSLSSSQSMS GSESTSTSVS DSQSSSTSNS 1900
    QFDSMSISAS ESDSMSTSDS SSISGSNSTS TSLSTSDSMS GSVSVSTSTS 1950
    LSDSISGSTS VSDSSSTSTS TSLSDSMSQS QSTSTSASGS LSTSISTSMS 2000
    MSASTSSSQS TSVSTSLSTS DSISDSTSIS ISGSQSTVES ESTSDSTSIS 2050
    DSESLSTSDS DSTSTSTSDS TSGSTSTSIS ESLSTSGSGS TSVSDSTSMS 2100
    ESNSSSVSMS QDKSDSTSIS DSESVSTSTS TSLSTSDSTS TSESLSTSMS 2150
    GSQSISDSTS TSMSGSTSTS ESNSMHPSDS MSMHHTHSTS TSRLSSEATT 2200
    STSESQSTLS ATSEVTKHNG TPAQSEKRLP DTGDSIKQNG LLGGVMTLLV 2250
    GLGLMKRKKK KDENDQDDSQ A 2271
    Length:2,271
    Mass (Da):228,077
    Last modified:March 21, 2006 - v1
    Checksum:i7E4A545A443EC5EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000255 Genomic DNA. Translation: ABD21900.1.
    RefSeqiYP_495223.1. NC_007793.1.

    Genome annotation databases

    EnsemblBacteriaiABD21900; ABD21900; SAUSA300_2589.
    GeneIDi3914100.
    KEGGisaa:SAUSA300_2589.
    PATRICi19594787. VBIStaAur129981_2769.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000255 Genomic DNA. Translation: ABD21900.1 .
    RefSeqi YP_495223.1. NC_007793.1.

    3D structure databases

    ProteinModelPortali Q2FDK5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 451515.SAUSA300_2589.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD21900 ; ABD21900 ; SAUSA300_2589 .
    GeneIDi 3914100.
    KEGGi saa:SAUSA300_2589.
    PATRICi 19594787. VBIStaAur129981_2769.

    Phylogenomic databases

    HOGENOMi HOG000280317.
    OMAi INNGGPV.
    OrthoDBi EOG6WX4ST.

    Enzyme and pathway databases

    BioCyci SAUR451515:GH3C-2589-MONOMER.

    Family and domain databases

    InterProi IPR015919. Cadherin-like.
    IPR008985. ConA-like_lec_gl_sf.
    IPR019948. Gram-positive_anchor.
    IPR022263. KxYKxGKxW.
    IPR019931. LPXTG_anchor.
    [Graphical view ]
    Pfami PF00746. Gram_pos_anchor. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 2 hits.
    SSF49899. SSF49899. 1 hit.
    TIGRFAMsi TIGR03715. KxYKxGKxW. 1 hit.
    TIGR01167. LPXTG_anchor. 1 hit.
    PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
      Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
      Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: USA300.

    Entry informationi

    Entry nameiSRAP_STAA3
    AccessioniPrimary (citable) accession number: Q2FDK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3