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Q2FDH1

- PCP_STAA3

UniProt

Q2FDH1 - PCP_STAA3

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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781UniRule annotation
Active sitei141 – 1411UniRule annotation
Active sitei165 – 1651UniRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciSAUR451515:GH3C-2623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:SAUSA300_2623
OrganismiStaphylococcus aureus (strain USA300)
Taxonomic identifieri367830 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001939: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Pyrrolidone-carboxylate peptidasePRO_1000050138Add
BLAST

Proteomic databases

PRIDEiQ2FDH1.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi451515.SAUSA300_2623.

Structurei

3D structure databases

ProteinModelPortaliQ2FDH1.
SMRiQ2FDH1. Positions 1-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242641.
KOiK01304.
OMAiKPNTPSM.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FDH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHILVTGFAP FDNQNINPSW EAVTQLEDII GTHTIDKLKL PTSFKKVDNI
60 70 80 90 100
INKTLASNHY DVVLAIGQAG GRNAITPERV AINIDDARIP DNDDFQPIDQ
110 120 130 140 150
AIHLDGAPAY FSNLPVKAMT QSIINQGLPG ALSNSAGTFV CNHTLYHLGY
160 170 180 190 200
LQDKHYPHLR FGFIHVPYIP EQVIGKPDTP SMPLEKIVAG LTAAIEAISN
210
DEDLHLALGT TE
Length:212
Mass (Da):23,167
Last modified:March 21, 2006 - v1
Checksum:iBBC76CD8FC43ACBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD20704.1.
RefSeqiYP_495257.1. NC_007793.1.

Genome annotation databases

EnsemblBacteriaiABD20704; ABD20704; SAUSA300_2623.
GeneIDi3913089.
KEGGisaa:SAUSA300_2623.
PATRICi19594861. VBIStaAur129981_2806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA. Translation: ABD20704.1 .
RefSeqi YP_495257.1. NC_007793.1.

3D structure databases

ProteinModelPortali Q2FDH1.
SMRi Q2FDH1. Positions 1-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 451515.SAUSA300_2623.

Proteomic databases

PRIDEi Q2FDH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD20704 ; ABD20704 ; SAUSA300_2623 .
GeneIDi 3913089.
KEGGi saa:SAUSA300_2623.
PATRICi 19594861. VBIStaAur129981_2806.

Phylogenomic databases

HOGENOMi HOG000242641.
KOi K01304.
OMAi KPNTPSM.
OrthoDBi EOG6X1124.

Enzyme and pathway databases

BioCyci SAUR451515:GH3C-2623-MONOMER.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
TIGRFAMsi TIGR00504. pyro_pdase. 1 hit.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300.

Entry informationi

Entry nameiPCP_STAA3
AccessioniPrimary (citable) accession number: Q2FDH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3