Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q2F8F7

- PAP1_ORFN2

UniProt

Q2F8F7 - PAP1_ORFN2

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Orf virus (strain NZ2) (OV NZ-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei191 – 1911By similarity
    Active sitei193 – 1931By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    Gene namesi
    Name:PAPL
    OrganismiOrf virus (strain NZ2) (OV NZ-2)
    Taxonomic identifieri10259 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeParapoxvirus
    Virus hostiCapra hircus (Goat) [TaxID: 9925]
    Homo sapiens (Human) [TaxID: 9606]
    Ovis aries (Sheep) [TaxID: 9940]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Poly(A) polymerase catalytic subunitPRO_0000308937Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2F8F7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2F8F7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPVIEEYL GSRPSMERCV LLRAQRRNMT RVLNFDRKLF LSLVVKSRRR    50
    FFKKLGGSEK EIAARIEEYF SRQRRLEKLG QILTVLELQS VIVSEFTRTL 100
    GSLTTPTPAI NAAVRRVDAP RARALASRAL NSYAVLPPPE EAAPMARHKH 150
    SDLVEVVKRL VKEHLRRHNK RCVCYGSYAL HLLNPEIEYG DIDMVQTNAR 200
    PFLINLAFLI YFVTGRQTVL LRVPYLKNYV VLQDEEGGHI LDSFNVRQAT 250
    LRALPTLLVD NIYVLHPFVQ LMAMLKMFSQ TDRIRDLADN FDKARARMET 300
    LLAFALEELG EAPADGRTPL PCAFLPPEGG ASRVLEADAR ALDCGFARAV 350
    VFLDEPALVQ TLLDMGVQDD EIVDFESVSN SAFLVRDNTL FTYFSNTVLM 400
    DGDAVHDLSR RGVSAHIVMF LLLTRHPAAE GAVRSMLGSL VSDARPVTSV 450
    VERERKTGTH GVIDIAKNVI TH 472
    Length:472
    Mass (Da):53,032
    Last modified:March 21, 2006 - v1
    Checksum:iFBE20290D08336F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ184476 Genomic DNA. Translation: ABA00535.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ184476 Genomic DNA. Translation: ABA00535.1 .

    3D structure databases

    ProteinModelPortali Q2F8F7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation."
      Mercer A.A., Ueda N., Friederichs S.M., Hofmann K., Fraser K.M., Bateman T., Fleming S.B.
      Virus Res. 116:146-158(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPAP1_ORFN2
    AccessioniPrimary (citable) accession number: Q2F8F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3