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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Orf virus (strain NZ2) (OV NZ-2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei191By similarity1
Active sitei193By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processmRNA processing, Transcription
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
OrganismiOrf virus (strain NZ2) (OV NZ-2)
Taxonomic identifieri10259 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeParapoxvirus
Virus hostiCapra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003089371 – 472Poly(A) polymerase catalytic subunitAdd BLAST472

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2F8F7.
SMRiQ2F8F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR037265. PolyA_pol_cat_sf.
IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxviridae_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
PfamiView protein in Pfam
PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.
SUPFAMiSSF160957. SSF160957. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2F8F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPVIEEYL GSRPSMERCV LLRAQRRNMT RVLNFDRKLF LSLVVKSRRR
60 70 80 90 100
FFKKLGGSEK EIAARIEEYF SRQRRLEKLG QILTVLELQS VIVSEFTRTL
110 120 130 140 150
GSLTTPTPAI NAAVRRVDAP RARALASRAL NSYAVLPPPE EAAPMARHKH
160 170 180 190 200
SDLVEVVKRL VKEHLRRHNK RCVCYGSYAL HLLNPEIEYG DIDMVQTNAR
210 220 230 240 250
PFLINLAFLI YFVTGRQTVL LRVPYLKNYV VLQDEEGGHI LDSFNVRQAT
260 270 280 290 300
LRALPTLLVD NIYVLHPFVQ LMAMLKMFSQ TDRIRDLADN FDKARARMET
310 320 330 340 350
LLAFALEELG EAPADGRTPL PCAFLPPEGG ASRVLEADAR ALDCGFARAV
360 370 380 390 400
VFLDEPALVQ TLLDMGVQDD EIVDFESVSN SAFLVRDNTL FTYFSNTVLM
410 420 430 440 450
DGDAVHDLSR RGVSAHIVMF LLLTRHPAAE GAVRSMLGSL VSDARPVTSV
460 470
VERERKTGTH GVIDIAKNVI TH
Length:472
Mass (Da):53,032
Last modified:March 21, 2006 - v1
Checksum:iFBE20290D08336F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ184476 Genomic DNA. Translation: ABA00535.1.

Similar proteinsi

Entry informationi

Entry nameiPAP1_ORFN2
AccessioniPrimary (citable) accession number: Q2F8F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 21, 2006
Last modified: November 22, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families