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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Orf virus (strain NZ2) (OV NZ-2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911By similarity
Active sitei193 – 1931By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
OrganismiOrf virus (strain NZ2) (OV NZ-2)
Taxonomic identifieri10259 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeParapoxvirus
Virus hostiCapra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Poly(A) polymerase catalytic subunitPRO_0000308937Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2F8F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2F8F7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPPVIEEYL GSRPSMERCV LLRAQRRNMT RVLNFDRKLF LSLVVKSRRR
60 70 80 90 100
FFKKLGGSEK EIAARIEEYF SRQRRLEKLG QILTVLELQS VIVSEFTRTL
110 120 130 140 150
GSLTTPTPAI NAAVRRVDAP RARALASRAL NSYAVLPPPE EAAPMARHKH
160 170 180 190 200
SDLVEVVKRL VKEHLRRHNK RCVCYGSYAL HLLNPEIEYG DIDMVQTNAR
210 220 230 240 250
PFLINLAFLI YFVTGRQTVL LRVPYLKNYV VLQDEEGGHI LDSFNVRQAT
260 270 280 290 300
LRALPTLLVD NIYVLHPFVQ LMAMLKMFSQ TDRIRDLADN FDKARARMET
310 320 330 340 350
LLAFALEELG EAPADGRTPL PCAFLPPEGG ASRVLEADAR ALDCGFARAV
360 370 380 390 400
VFLDEPALVQ TLLDMGVQDD EIVDFESVSN SAFLVRDNTL FTYFSNTVLM
410 420 430 440 450
DGDAVHDLSR RGVSAHIVMF LLLTRHPAAE GAVRSMLGSL VSDARPVTSV
460 470
VERERKTGTH GVIDIAKNVI TH
Length:472
Mass (Da):53,032
Last modified:March 21, 2006 - v1
Checksum:iFBE20290D08336F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ184476 Genomic DNA. Translation: ABA00535.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ184476 Genomic DNA. Translation: ABA00535.1.

3D structure databases

ProteinModelPortaliQ2F8F7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation."
    Mercer A.A., Ueda N., Friederichs S.M., Hofmann K., Fraser K.M., Bateman T., Fleming S.B.
    Virus Res. 116:146-158(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_ORFN2
AccessioniPrimary (citable) accession number: Q2F8F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 21, 2006
Last modified: October 1, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.