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Q2F8F7 (PAP1_ORFN2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase catalytic subunit

EC=2.7.7.19
Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L
Gene names
Name:PAPL
OrganismOrf virus (strain NZ2) (OV NZ-2)
Taxonomic identifier10259 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeParapoxvirus
Virus hostCapra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.

Sequence similarities

Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
   Biological processmRNA processing
Transcription
   LigandATP-binding
Nucleotide-binding
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

polynucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Poly(A) polymerase catalytic subunit
PRO_0000308937

Sites

Active site1911 By similarity
Active site1931 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2F8F7 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: FBE20290D08336F9

FASTA47253,032
        10         20         30         40         50         60 
MAPPVIEEYL GSRPSMERCV LLRAQRRNMT RVLNFDRKLF LSLVVKSRRR FFKKLGGSEK 

        70         80         90        100        110        120 
EIAARIEEYF SRQRRLEKLG QILTVLELQS VIVSEFTRTL GSLTTPTPAI NAAVRRVDAP 

       130        140        150        160        170        180 
RARALASRAL NSYAVLPPPE EAAPMARHKH SDLVEVVKRL VKEHLRRHNK RCVCYGSYAL 

       190        200        210        220        230        240 
HLLNPEIEYG DIDMVQTNAR PFLINLAFLI YFVTGRQTVL LRVPYLKNYV VLQDEEGGHI 

       250        260        270        280        290        300 
LDSFNVRQAT LRALPTLLVD NIYVLHPFVQ LMAMLKMFSQ TDRIRDLADN FDKARARMET 

       310        320        330        340        350        360 
LLAFALEELG EAPADGRTPL PCAFLPPEGG ASRVLEADAR ALDCGFARAV VFLDEPALVQ 

       370        380        390        400        410        420 
TLLDMGVQDD EIVDFESVSN SAFLVRDNTL FTYFSNTVLM DGDAVHDLSR RGVSAHIVMF 

       430        440        450        460        470 
LLLTRHPAAE GAVRSMLGSL VSDARPVTSV VERERKTGTH GVIDIAKNVI TH 

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References

[1]"Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation."
Mercer A.A., Ueda N., Friederichs S.M., Hofmann K., Fraser K.M., Bateman T., Fleming S.B.
Virus Res. 116:146-158(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ184476 Genomic DNA. Translation: ABA00535.1.

3D structure databases

ProteinModelPortalQ2F8F7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFPIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNetSearch...

Entry information

Entry namePAP1_ORFN2
AccessionPrimary (citable) accession number: Q2F8F7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families