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Protein

C-C motif chemokine

Gene

CCL5

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_302689. Chemokine receptors bind chemokines.
REACT_306633. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
Gene namesi
Name:CCL5Imported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 12

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323UniRule annotationAdd
BLAST
Chaini24 – 9168C-C motif chemokineUniRule annotationPRO_5001366085Add
BLAST

Expressioni

Gene expression databases

GenevisibleiQ2EN89. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028561.

Structurei

3D structure databases

ProteinModelPortaliQ2EN89.
SMRiQ2EN89. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
KOiK12499.
OMAiQEYFYTS.
TreeFamiTF334888.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2EN89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTAALAV ILAMAALCAP ASASPYASDT TPCCFSYLSR PLPRAHLQEY
60 70 80 90
FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINSLEL S
Length:91
Mass (Da):10,041
Last modified:March 21, 2006 - v1
Checksum:i82EA6FC0D11EDE3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU896616 Genomic DNA. No translation available.
DQ372066 mRNA. Translation: ABD18445.1.
RefSeqiNP_001123418.1. NM_001129946.1.
UniGeneiSsc.22030.

Genome annotation databases

EnsembliENSSSCT00000019271; ENSSSCP00000018760; ENSSSCG00000017705.
ENSSSCT00000033821; ENSSSCP00000028561; ENSSSCG00000017705.
GeneIDi396613.
KEGGissc:396613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU896616 Genomic DNA. No translation available.
DQ372066 mRNA. Translation: ABD18445.1.
RefSeqiNP_001123418.1. NM_001129946.1.
UniGeneiSsc.22030.

3D structure databases

ProteinModelPortaliQ2EN89.
SMRiQ2EN89. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000019271; ENSSSCP00000018760; ENSSSCG00000017705.
ENSSSCT00000033821; ENSSSCP00000028561; ENSSSCG00000017705.
GeneIDi396613.
KEGGissc:396613.

Organism-specific databases

CTDi6352.

Phylogenomic databases

GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
KOiK12499.
OMAiQEYFYTS.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_302689. Chemokine receptors bind chemokines.
REACT_306633. G alpha (i) signalling events.

Gene expression databases

GenevisibleiQ2EN89. SS.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular Cloning of Porcine Chemokine, CCL5."
    Yang J., Cho B.R., Choi I., Kim D., Kim S.D., Kim J.Y., Ahn C.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. Ensembl
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ2EN89_PIG
AccessioniPrimary (citable) accession number: Q2EN89
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: June 24, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.