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Q2EN89

- Q2EN89_PIG

UniProt

Q2EN89 - Q2EN89_PIG

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Protein
Submitted name: C-C motif chemokine 5
Gene
CCL5
Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. phosphatidylinositol phospholipase C activity Source: Ensembl
  3. phospholipase activator activity Source: Ensembl
  4. protein kinase activity Source: Ensembl
  5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. activation of phospholipase D activity Source: Ensembl
  3. calcium ion transport Source: Ensembl
  4. cell-cell signaling Source: Ensembl
  5. cellular calcium ion homeostasis Source: Ensembl
  6. cellular protein complex assembly Source: Ensembl
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cellular response to interferon-gamma Source: Ensembl
  9. cellular response to interleukin-1 Source: Ensembl
  10. cellular response to organic cyclic compound Source: Ensembl
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. eosinophil chemotaxis Source: Ensembl
  13. exocytosis Source: Ensembl
  14. inflammatory response Source: Ensembl
  15. leukocyte cell-cell adhesion Source: Ensembl
  16. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  17. negative regulation by host of viral transcription Source: Ensembl
  18. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  19. negative regulation of T cell apoptotic process Source: Ensembl
  20. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
  21. negative regulation of macrophage apoptotic process Source: Ensembl
  22. negative regulation of viral genome replication Source: Ensembl
  23. neutrophil activation Source: Ensembl
  24. positive regulation of T cell apoptotic process Source: Ensembl
  25. positive regulation of T cell chemotaxis Source: Ensembl
  26. positive regulation of T cell proliferation Source: Ensembl
  27. positive regulation of calcium ion transport Source: Ensembl
  28. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
  29. positive regulation of cellular biosynthetic process Source: Ensembl
  30. positive regulation of epithelial cell proliferation Source: Ensembl
  31. positive regulation of homotypic cell-cell adhesion Source: Ensembl
  32. positive regulation of macrophage chemotaxis Source: Ensembl
  33. positive regulation of monocyte chemotaxis Source: Ensembl
  34. positive regulation of natural killer cell chemotaxis Source: Ensembl
  35. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  36. positive regulation of smooth muscle cell migration Source: Ensembl
  37. positive regulation of smooth muscle cell proliferation Source: Ensembl
  38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  39. protein kinase B signaling Source: Ensembl
  40. protein tetramerization Source: Ensembl
  41. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_202825. G alpha (i) signalling events.
REACT_226269. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Submitted name:
C-C motif chemokine 5Imported
Submitted name:
CCL5Imported
Gene namesi
Name:CCL5Imported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliQ2EN89.
SMRiQ2EN89. Positions 24-91.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
KOiK12499.
OMAiCSIPAVV.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2EN89-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSTAALAV ILAMAALCAP ASASPYASDT TPCCFSYLSR PLPRAHLQEY   50
FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINSLEL S 91
Length:91
Mass (Da):10,041
Last modified:March 21, 2006 - v1
Checksum:i82EA6FC0D11EDE3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU896616 Genomic DNA. No translation available.
DQ372066 mRNA. Translation: ABD18445.1.
RefSeqiNP_001123418.1. NM_001129946.1.
UniGeneiSsc.22030.

Genome annotation databases

EnsembliENSSSCT00000019271; ENSSSCP00000018760; ENSSSCG00000017705.
ENSSSCT00000033821; ENSSSCP00000028561; ENSSSCG00000017705.
GeneIDi396613.
KEGGissc:396613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU896616 Genomic DNA. No translation available.
DQ372066 mRNA. Translation: ABD18445.1 .
RefSeqi NP_001123418.1. NM_001129946.1.
UniGenei Ssc.22030.

3D structure databases

ProteinModelPortali Q2EN89.
SMRi Q2EN89. Positions 24-91.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000019271 ; ENSSSCP00000018760 ; ENSSSCG00000017705 .
ENSSSCT00000033821 ; ENSSSCP00000028561 ; ENSSSCG00000017705 .
GeneIDi 396613.
KEGGi ssc:396613.

Organism-specific databases

CTDi 6352.

Phylogenomic databases

GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
KOi K12499.
OMAi CSIPAVV.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_202825. G alpha (i) signalling events.
REACT_226269. Chemokine receptors bind chemokines.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular Cloning of Porcine Chemokine, CCL5."
    Yang J., Cho B.R., Choi I., Kim D., Kim S.D., Kim J.Y., Ahn C.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. Ensembl
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ2EN89_PIG
AccessioniPrimary (citable) accession number: Q2EN89
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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