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Q2EN89

- Q2EN89_PIG

UniProt

Q2EN89 - Q2EN89_PIG

Protein

C-C motif chemokine

Gene

CCL5

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. phosphatidylinositol phospholipase C activity Source: Ensembl
    3. phospholipase activator activity Source: Ensembl
    4. protein kinase activity Source: Ensembl
    5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

    GO - Biological processi

    1. activation of phospholipase D activity Source: Ensembl
    2. calcium ion transport Source: Ensembl
    3. cell-cell signaling Source: Ensembl
    4. cellular calcium ion homeostasis Source: Ensembl
    5. cellular protein complex assembly Source: Ensembl
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to interferon-gamma Source: Ensembl
    8. cellular response to interleukin-1 Source: Ensembl
    9. cellular response to organic cyclic compound Source: Ensembl
    10. cellular response to tumor necrosis factor Source: Ensembl
    11. eosinophil chemotaxis Source: Ensembl
    12. exocytosis Source: Ensembl
    13. inflammatory response Source: Ensembl
    14. leukocyte cell-cell adhesion Source: Ensembl
    15. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    16. MAPK cascade Source: Ensembl
    17. negative regulation by host of viral transcription Source: Ensembl
    18. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
    19. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    20. negative regulation of macrophage apoptotic process Source: Ensembl
    21. negative regulation of T cell apoptotic process Source: Ensembl
    22. negative regulation of viral genome replication Source: Ensembl
    23. neutrophil activation Source: Ensembl
    24. positive regulation of calcium ion transport Source: Ensembl
    25. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
    26. positive regulation of cellular biosynthetic process Source: Ensembl
    27. positive regulation of epithelial cell proliferation Source: Ensembl
    28. positive regulation of homotypic cell-cell adhesion Source: Ensembl
    29. positive regulation of macrophage chemotaxis Source: Ensembl
    30. positive regulation of monocyte chemotaxis Source: Ensembl
    31. positive regulation of natural killer cell chemotaxis Source: Ensembl
    32. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    33. positive regulation of smooth muscle cell migration Source: Ensembl
    34. positive regulation of smooth muscle cell proliferation Source: Ensembl
    35. positive regulation of T cell apoptotic process Source: Ensembl
    36. positive regulation of T cell chemotaxis Source: Ensembl
    37. positive regulation of T cell proliferation Source: Ensembl
    38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
    39. protein kinase B signaling Source: Ensembl
    40. protein tetramerization Source: Ensembl
    41. response to toxic substance Source: Ensembl

    Keywords - Molecular functioni

    CytokineUniRule annotationSAAS annotation

    Keywords - Biological processi

    ChemotaxisUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_202825. G alpha (i) signalling events.
    REACT_226269. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokineUniRule annotation
    Gene namesi
    Name:CCL5Imported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 12

    Subcellular locationi

    Secreted UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    SecretedUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ2EN89.
    SMRiQ2EN89. Positions 24-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the intercrine beta (chemokine CC) family.UniRule annotation

    Keywords - Domaini

    SignalUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    KOiK12499.
    OMAiCSIPAVV.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2EN89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSTAALAV ILAMAALCAP ASASPYASDT TPCCFSYLSR PLPRAHLQEY   50
    FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINSLEL S 91
    Length:91
    Mass (Da):10,041
    Last modified:March 21, 2006 - v1
    Checksum:i82EA6FC0D11EDE3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU896616 Genomic DNA. No translation available.
    DQ372066 mRNA. Translation: ABD18445.1.
    RefSeqiNP_001123418.1. NM_001129946.1.
    UniGeneiSsc.22030.

    Genome annotation databases

    EnsembliENSSSCT00000019271; ENSSSCP00000018760; ENSSSCG00000017705.
    ENSSSCT00000033821; ENSSSCP00000028561; ENSSSCG00000017705.
    GeneIDi396613.
    KEGGissc:396613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU896616 Genomic DNA. No translation available.
    DQ372066 mRNA. Translation: ABD18445.1 .
    RefSeqi NP_001123418.1. NM_001129946.1.
    UniGenei Ssc.22030.

    3D structure databases

    ProteinModelPortali Q2EN89.
    SMRi Q2EN89. Positions 24-91.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000019271 ; ENSSSCP00000018760 ; ENSSSCG00000017705 .
    ENSSSCT00000033821 ; ENSSSCP00000028561 ; ENSSSCG00000017705 .
    GeneIDi 396613.
    KEGGi ssc:396613.

    Organism-specific databases

    CTDi 6352.

    Phylogenomic databases

    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    KOi K12499.
    OMAi CSIPAVV.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_202825. G alpha (i) signalling events.
    REACT_226269. Chemokine receptors bind chemokines.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular Cloning of Porcine Chemokine, CCL5."
      Yang J., Cho B.R., Choi I., Kim D., Kim S.D., Kim J.Y., Ahn C.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Porcine genome sequencing project
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
    4. Ensembl
      Submitted (NOV-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ2EN89_PIG
    AccessioniPrimary (citable) accession number: Q2EN89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3