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Protein

C-C motif chemokine

Gene

CCL5

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation

Enzyme and pathway databases

ReactomeiR-SSC-380108 Chemokine receptors bind chemokines
R-SSC-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
Gene namesi
Name:CCL5Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_501448666124 – 91C-C motif chemokineUniRule annotationAdd BLAST68

Expressioni

Gene expression databases

BgeeiENSSSCG00000017705

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 88SCYInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J0XH Eukaryota
ENOG410ZUYI LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
KOiK12499
OMAiCCFAYLS
OrthoDBiEOG091G14Y2
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR030595 CCL5
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF82 PTHR12015:SF82, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2EN89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTAALAV ILAMAALCAP ASASPYASDT TPCCFSYLSR PLPRAHLQEY
60 70 80 90
FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINSLEL S
Length:91
Mass (Da):10,041
Last modified:March 21, 2006 - v1
Checksum:i82EA6FC0D11EDE3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000080 Genomic DNA No translation available.
DQ372066 mRNA Translation: ABD18445.1
RefSeqiNP_001123418.1, NM_001129946.1
XP_013845402.1, XM_013989948.1
UniGeneiSsc.22030

Genome annotation databases

EnsembliENSSSCT00000033821; ENSSSCP00000028561; ENSSSCG00000017705
GeneIDi396613
KEGGissc:396613

Similar proteinsi

Entry informationi

Entry nameiQ2EN89_PIG
AccessioniPrimary (citable) accession number: Q2EN89
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health