Reviewed, UniProtKB/Swiss-Prot Q2EN02 (SRG_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative survival-related protein

Gene names

Name:	CASZ1
Synonyms:	SRG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Uncertain.

General annotation (Comments)

Caution

Product of a dubious gene prediction. This CDS is encoded on the 3'-UTR of CASZ1 gene. There is no evidence for its expression at the protein level and its putative function as an anti-apoptotic factor is not confirmed.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Putative survival-related protein		PRO_0000316022
Natural variations
	Natural variant	130	1	C → F: dbSNP rs4845938.		VAR_038353

Sequences

	Sequence		Length	Mass (Da)
	Q2EN02-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 478871977C9C791D	FASTA	172	18,404
	10 20 30 40 50 60 MLLRWCSLPR LGSLCKTSPF LEMMMPSKPG PGPDLAGTHL ASGSEVPGDR VPCEGRLPEA 70 80 90 100 110 120 TPAHLPYSRP PAGVRLGHRE RTGLGGNGRL AGRLSSRSLL PRGLQEEPGS TGGQWFTFPF 130 140 150 160 170 FLPFFCPLSC PQPESQDHPN WTGSREGGVV ARSVPDSTGN QLFSKTAPTR AS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis." Yuan Z.-R., Wang R., Solomon J., Luo X., Sun H., Zhang L., Shi Y. Cancer Res. 65:10716-10724(2005) [PubMed: 16322216] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-130. Tissue: Rectum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ372703 mRNA. Translation: ABD14411.1. AK130996 mRNA. Translation: BAC85474.1.
UniGene	Hs.439894 Hs.703785
3D structure databases
ModBase	Search...
Organism-specific databases
HGNC	HGNC:26002. CASZ1.
MIM	609895. gene.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q2EN02.
HOVERGEN	Q2EN02.
Gene expression databases
CleanEx	HS_CASZ1.
Family and domain databases
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

SRG_HUMAN

Accession

Primary (citable) accession number: Q2EN02
Secondary accession number(s): Q6ZNM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	July 22, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)